Individuals may develop symptoms in response to inhaled odors, chemicals, and irritants. This may affect their quality of life. Little is known about the prevalence and severity of symptoms that result from exposure to odors, chemicals and irritants. This study demonstrates the development of a new respiratory questionnaire to detect the prevalence and severity of symptoms experienced upon exposure to chemicals, odors, and irritants, and relates these symptoms to quality of life. This questionnaire was submitted to 96 volunteers at the University of South Florida College of Public Health who responded to items regarding symptoms developed in response to exposure to automobile exhaust, cigarette smoke, strong smells, cologne, perfumes or scented candles, or fresh paint vapors or fumes. Health-related quality of life was assessed using a subscale included with the questionnaire. The number and severity of symptoms developed in response to exposure to odors, chemicals, and irritants showed a strong negative correlation with health-related quality of life, consistent with intuitive estimates of the direction of this relationship. Also, it was shown that in normal populations, males and females develop statistically similar prevalence and severity of symptoms in response to exposure to odors, chemicals, and irritants.