Thesis (Ph. D.)--University of Oregon, 2003. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 159-180). Also available for download via the World Wide Web; free to University of Oregon users.

No description available.

Mutations in the clk-1 gene of Caenorhabditis elegans result in an average slowing down and deregulation of a variety of developmental and physiological processes. In addition, clk-1 mutants are defective in responding to temperature changes. For example, wild-type worms adjust their defecation cycle length after a temperature shift whereas the defecation cycle length of clk-1 mutants is unaffected by such a shift. To understand the basis of the clk-1 phenotype, a number of genetic screens have been carried out to isolate feature-specific suppressor mutations. dsc-3(qm179) and dsc-4(qm182) were isolated in this manner. It has previously been found that dsc-3(qm179) and dsc-4(qm182) strongly suppress the slow defecation phenotype of clk-1 mutants at 20°C, as well as after a temperature shift to 25°C. Molecular analysis of dsc-4, which encodes the microsomal triglyceride transfer protein, suggests that dsc genes affect lipid metabolism. We carried out a genetic screen for additional mutations that can suppress the slow defecation of clk-1 mutants after a temperature shift to 25°C and isolated two new suppressor mutations. Complementation tests as well as linkage analysis and mapping indicates that dsc-6(qm192) and dsc-7(qm193) define new dsc genes. We analyzed the phenotype of the new suppressor strains and have found that, like dsc-4(qm182), dsc-6(qm192) and dsc-7(qm193) can suppress a variety of clk-1 phenotypes. Based on additional phenotypic analyses of the new suppressor strains, including the determination of their sensitivity to exogenous cholesterol, we believe that, like dsc-4, dsc-6 and dsc-7 encode activities that affect lipid metabolism in worms.

Thesis (Ph. D.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references (p. 118-123).

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008. / Includes bibliographical references (leaves 82-87). Also available in electronic version.

Thesis (M.S.)--Missouri State University, 2008. / "May 2008." Includes bibliographical references (leaves 49-52). Also available online.

Thesis (M.A.)--Humboldt State University, 2008. / Includes bibliographical references (leaves 98-104). Also available via Humboldt Digital Scholar.

Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: Neuroscience; migration; yeast two-hybrid; MIG-10. Includes bibliographical references (leaves 58-60).

Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 61-64).

Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Cell and Developmental Biology." Includes bibliographical references (p. 154-174).