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Physical and chemical effects of carcinogen binding to DNA in relation to biological activity and statistical problems in chemical carcinogenesisDrinkwater, Norman R. January 1980 (has links)
Thesis--University of Wisconsin--Madison. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Synthetic and spectral studies of potential anticancer drugsSobhanian, Ali January 1997 (has links)
No description available.
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The development of methods for the detection of modified DNAMcConnell, Ian Reginald January 1995 (has links)
No description available.
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Radiation carcinogenesis and delayed lethal damage in a human thyroid epithelial cell lineMercer, John January 1999 (has links)
The human thyroid epithelial cell HTori-3 has been transformed with doses of either chronic and acute x-rays or strontium beta particles. Models of the past have relied upon animal cell systems to mimic in vitro carcinogenesis. The HTori-3 system hoped to overcome the limitations associated with these types of models by using a human thyroid cell line immortalised with the SV40 virus. HTori-3 human thyroid epithelial cells were irradiated in vitro, passaged and then transplanted into nude mice. Tumours that grew over a 2-6 month period were excised and re-established in culture. Samples were stored and all tumours were taken for histological examination. Chromosome spreads confirmed the human nature of all tumours. Following exposure to acute x-rays in the range of 0.25-2.0 Gy 13 tumours were observed in 25 recipients. Following 0.25-2.0 Gy of chronic x-rays 10 tumours from 25 recipients were observed. From a single 2 Gy exposure of strontium beta particles 3 primary tumours from 5 recipients were observed. The largest of these was re-transplanted in nude mice resulting in 100% incidence. All tumours were classified as undifferentiated anaplastic carcinomas. A small number of tumours were observed in the control cell lines, these may be the result of a general instability found with the partial transformed parental cell line. All 2Gy tumours and those previously established from this laboratory after alpha or gamma radiation were used to test for the presence of the delayed lethal death phenotype. A number of cell and molecular endpoints were used. These included plating efficiency, cell adherence, micronucleus formation and p53 status. In all incidences, the reproductive viability of irradiated cells was below that of non- irradiated cells at up to 4 weeks post-irradiation. The HTori-3 cell line and the techniques used to study the delayed effects of radiation may be applicable to other cell systems and may be a useful model to study the long-term effects of radiation induced genomic instability.
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Arylhydrazine carcinogenesis and the synthesis of C8-arylpurine oligonucleotides a study of DNA adduct affects on DNA conformation and stability /Daft, Jonathan R., January 1900 (has links)
Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains xi, 323 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 191-211).
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Consequences of the regulation of DNA damage and other host responses by fish oil for colorectal oncogenesisNyskohus, Laura Sophia, Unknown Date (has links)
Thesis (Ph.D.)--Flinders University, School of Medicine, Dept. of Gastroenterology. / Typescript bound. Includes bibliographical references: (leaves 215-233) Also available in an electronic version via the Web.
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