Three-dimensional two-phase unsteady CFD simulations were run on three and four-blade inducers for the purpose of analyzing differences in cavitation stability at design and off-design flow rates. At design flow rates, there were very small differences between the breakdown curves for the three and four-bladed inducers. However, at lower cavitation numbers, the three-bladed inducer exhibited up to three times the rotor forces than the four-bladed inducer. When moving to off-design flow rates, both inducers experienced multiple modes of cavitation instabilities including rotating cavitation, alternate-blade cavitation, and cavitation surge. The four-bladed inducer began experiencing the formation of these modes of instability beginning at a cavitation number of $sigma = 0.047$ whereas the three-bladed inducer began at a cavitation number of $sigma = 0.091$. Additionally, the three-bladed inducer showed rotor forces up to ten times higher than the four-bladed inducer at similar cavitation numbers.Three-dimensional single-phase steady CFD simulations were run on four-blade inducer geometries with $7^{circ}$, $9^{circ}$, $11^{circ}$ and $14^{circ}$ inlet tip blade angles with a stability control device (SCD) installed. The simulations were ran at multiple flow coefficients. Results show interesting flow effects from the SCD. For example, at lower flow coefficients, the incidence angle actually decreases at greater than 70\% span. This is due to a region of accelerated axial flow coming from the recirculation of the SCD which occurs near the shroud. Results also show strong correlations between efficiency and head rise to the local mass flow gain experienced due to the recirculating flow through the SCD. A best fit curve was generated to predict mass flow gain based on the inducer's inlet tip blade angle and flow coefficient. Based on this research, the ability to predict mass flow gain and consequently efficiency and head rise for similarly designed inducers with varying inlet blade angles has been demonstrated.

Yes / Cavitation is an important phenomenon in solid-phase deformation of polymers, which either has potential adverse effects on physical properties or creates potential opportunities for new properties. In either case, it needs to be better understood to help achieve better control of cavitation and its effects. Cavitation associated with solid-phase deformation in a β-nucleated isotactic polypropylene was found to depend on the solid-phase deformation route employed. Compared with samples obtained by free tensile stretching, cavitation was suppressed in samples deformed via die-drawing, although an almost identical β-to α-phase transition was observed for both deformation routes. Even when die-drawn samples were subsequently deformed to large strains by free stretching, there was still no comparable cavitation compared with the single free tensile-stretching route. The die-drawing process appears to suppress cavitation by fundamentally diminishing the number of growable nuclei of cavities, rather than merely hindering the growth of cavities. A relationship between cavitation intensity and the fractions of lamellae along specific directions has been established. During subsequent free stretching of die-drawn samples, newly created cavities were suggested to be initiated within the crystalline layers. The reduction of the cavity nuclei in the die-drawing process originated from the stabilization of the connections between the crystalline blocks within the lamellae. / This work is supported by the National Natural Science Foundation of China (21704102 and 51525305), Newton Advanced Fellowship of the Royal Society, United Kingdom (NA 150222) and ExxonMobil.

The relationship between cells and their environment is one of dynamic reciprocity, whereby cells can influence their surrounding and the surroundings can influence the cells. One example of this relationship arises from the effect of the mechanical properties of an environment on a cell and of a cell on its environment. Inspired by this relationship, we investigate 1) the local environment of biological materials, both native and synthetic, and 2) the forces that cell sheets exert on surfaces. We do this by developing techniques that focus on local mechanical properties and experimental strategies that provide insight into intercellular mechanics. We first focus on determining local mechanical properties of hydrogel materials by developing the Cavitation Rheology technique. This process involves inducing a cavitation event at the tip of a syringe needle. We develop theory to show that the critical pressure to cavitate can be directly related to the modulus of the material (Chapter 2). This allows us to experimentally determine the mechanical properties at arbitrary locations throughout a material scaffold over a range of length scales defined by the needle radius (Chapter 3). We then demonstrate that we can viturally elminate the energy contribution from the creation of new surface area to the critical pressure by cavitating with a media of lower surface energy (Chapter 4). In chapter 5, we show that Cavitation Rheology can be used on native biological tissues and we go on to demonstrate the importance of measuring the mechanical properties in vivo. We then focus on understanding the force development of cells as they grow to confluency on a dynamic substrate (Chapter 6). We demonstrate the method of living microlenses to measure the collective strains cell sheets attain by growing cells on a thin polystyrene film supported by a surface of microwells. The cells cause the film to buckle and the resultant buckling can be directly related to the strain. We use this technique to study the strains exerted by various cell types and to determine the importance of the cell-cell junctions on the strain development.

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Cavitation is detrimental to the performance of ships and submarines, causing noise, erosion, and vibration. This study seeks to understand cavitation inception and delay on a typical ducted propulsor by utilizing the SimCenter's unstructured simulation and design system: U2NCLE. Specifically, three fundamental questions are addressed: 1. What are the macroscale flow physics causing cavitation inception? 2. How does cavitation inception scale with Reynolds number? 3. How can tip-leakage vortex cavitation inception be suppressed? To study the physics of cavitation inception, a ducted propulso simulation is developed and extensively validated with experimental results. The numerical method is shown to agree very well with experimental measurements made in the vortex core. It was discovered that the interaction of the leakage and trailing edge vortices cause the pressure to drop to a local minimum, providing ideal conditions for inception to occur. However, experimental observation shows that inception does not occur at the minimum pressure location, but rather at the point where the two vortices completely coalesce. At the point of coalescence, the simulation reveals that the streamwise core velocity decelerates, causing the air nuclei to stretch and burst. A Reynolds number scaling analysis is performed for the minimum pressure and maximum velocity in the vortex core. First, the numerical method is validated on a flate plate at various Reynolds numbers to assess the ability of typical turbulence models to predict Reynolds numbers ranging from one million to one billion. This scaling analysis methodology is then applied to the propulsor simulation, revealing that the minimum pressure in the vortex core is much less dependent on Reynolds number than was previously hypothesized. Lastly, to investigate means of delaying cavitation inception, the propulsor is parameterized and studied using design optimization theory. Concepts of vortex alleviation evident in nature are used to suggest suitable parameterizations. Also, dimension reduction is used to reduced the number of design variables. Finally, the concepts are implemented, evaluated, and shown to completely decouple the two vortices causing cavitation inception. Moreover, the minimum pressure in the vortex core is significantly increased.

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