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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Protein structures and interactions at the leukocyte cell surface

Evans, Edward James January 2002 (has links)
No description available.
2

The role of CAS and its binding proteins in cell signaling pathways /

DeBerry, Regina Marie. January 2000 (has links)
Thesis (Ph. D.)--University of Virginia, 2000. / Includes bibliographical references (leaves 143-182). Also available online through Digital Dissertations.
3

Cell interactions in the CNS and their consequences for neuronal apoptosis /

Berglund, Mikaela, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 4 uppsatser.
4

The M-factor pheromone from the fission yeast Schizosaccharomyces pombe : investigation into its proteolysis

Hughes, Marcus Daniel January 1999 (has links)
No description available.
5

A structural and functional analysis of lacritin : ocular and salivary cell mitogenesis /

Walton, Staci Camille. January 2006 (has links)
Thesis (Ph. D.)--University of Virginia, 2006. / Includes bibliographical references. Also available online through Digital Dissertations.
6

Inter- and Intra-kingdom Signaling in Bacterial Chemotaxis, Biofilm Formation, and Virulence

Hegde, Manjunath 2011 December 1900 (has links)
Cell-cell communication between bacteria, belonging to the same species or to different species (Intra-kingdom signaling), or communication between bacteria and their animal host (Inter-kingdom signaling) is mediated through different chemical signals that are synthesized and secreted by bacteria or the host and is crucial for the survival of bacteria inside their host. The overall goal of this work was to understand the role of inter- and intra-kingdom signaling in phenotypes such as chemotaxis, colonization and biofilm formation, and virulence that are associated with infections caused by the human gastrointestinal (GI) tract pathogens. A part of our work also aimed at developing microfluidics-based models to study inter- and intra-kingdom signaling in biofilm formation, inhibition, and dispersal. We showed that norepinephrine (NE), an important host signal produced during stress, increases human opportunistic pathogen Pseudomonas aeruginosa growth, motility, attachment, and virulence, and also showed that the actions of NE are mediated primarily through the LasR, and not the RhlR QS system. We investigated the molecular mechanism underlying the chemo-sensing of the intra-kingdom signal autoinducer-2 (AI-2) by pathogens Escherichia coli and Salmonella typhimurium by performing different chemotaxis assays (capillary, microPlug and microFlow assays), and discovered that AI-2 is a potent attractant for E. coli and S. typhimurium, and that the Tsr chemoreceptor and periplasmic AI-2 binding protein LsrB are necessary for sensing AI-2, although uptake of AI-2 into the cytoplasm is not required. We concluded that LsrB, when bound to AI-2, interacts directly with the periplasmic domain of Tsr primarily at the Thr-61 and Asp-63 residues of LsrB, making LsrB the first known periplasmic-protein partner for Tsr. We fabricated a simple user-friendly microfluidic flow cell (microBF) device that can precisely measure the effect of a wide range of concentrations of single or combinations of two or more soluble signals on bacterial biofilm formation and development. We also constructed a synthetic biofilm circuit that utilizes the Hha and BdcA dispersal proteins of E. coli along with a quorum sensing (QS) switch that works based on the accumulation of the signal N-(3-oxo-dodecanoyl)-L-homoserine lactone (3-o-C12HSL) and implemented it in an upgraded �BF device. We showed that a QS system may be utilized with biofilm dispersal proteins to control consortial biofilm formation by removing an existing biofilm and then removing the biofilm that displaced the first one. These types of synthetic QS circuits may be used to pattern biofilms by facilitating the re-use of platforms and to create sophisticated reactor systems that will be used to form bio-refineries.
7

Cellular interactions with extracellular matrix during development and in muscle disease /

Tiger, Carl-Fredrik. January 2002 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 4 uppsatser.
8

Characterization of palladin, a novel protein involved in the organization of the actin cystoskeleton /

Parast, Mana Mosamma. January 2000 (has links)
Thesis (Ph. D.)--University of Virginia, 2000. / Spine title: Palladin & actin organization. Includes bibliographical references (leaves 209-251). Also available online through Digital Dissertations.
9

Sphingolipid signaling in human platelets /

Simon, Carl George. January 1999 (has links)
Thesis (Ph. D.)--University of Virginia, 1999. / Spine title: Sphingolipid signaling in platelets. Includes bibliographical references (p. 134-144). Also available online through Digital Dissertations.
10

Analysis of the histidine kinase UhpB transmitter domain and its interaction with the response regulator UhpA /

Wright, Jesse Sterling. January 2000 (has links)
Thesis (Ph. D.)--University of Virginia, 2000. / Includes bibliographical references (leaves 141-154). Also available online through Digital Dissertations.

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