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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

The caspase-3 dependent coverage of eIF4G during the induction of apoptosis

Bushell, Martin January 1999 (has links)
No description available.

The induction of apoptosis by the human papillomavirus type 16 E2 protein

Parish, Joanna L. January 2001 (has links)
No description available.

Role of Bad in regulating T cell apoptosis

Mok, Chen-Lang January 2002 (has links)
No description available.

Analysis of components of the Caenorhabditis elegans cell death apparatus in a heterologous system

James, Claerwen Laura January 1998 (has links)
No description available.

Regulation of endothelial cell apoptosis and its role it the pathogenesis of HUS and multiple myeloma

Molostvov, Guerman January 2002 (has links)
No description available.

Molecular mechanisms involved in constitutive neutrophil apoptosis and its modulation by inflammatory mediators

Magowan, Lorna January 2000 (has links)
No description available.

Apoptosis of human osteoblasts cultured on polymeric biomaterials in vitro

Gough, Julie January 1999 (has links)
No description available.

A study of programmed cell death in cotton (gosypium hirsutum) fiber

Roche, Meghan C. 15 May 2009 (has links)
Cotton fiber has been postulated to undergo a process of programmed cell death (PCD) during the maturation phase of development. A parallel may exist between cotton fibers and xylem tracheary elements, which have periods of elongation, secondary cell wall deposition and death. Secondary wall formation and PCD are purported to be coupled events in tracheary elements. In this study, an attempt was made to observe the occurrence and timing of PCD in cotton fibers by TUNEL staining to detect DNA strand breaks, and also to monitor DNA content by PI staining. The staining patterns produced by PI and TUNEL left room for interpretation. TUNEL-positive and PI-stained areas were observed, but failure to observe nuclei of conventional appearance in my cytological preparations at any time-point, along with possible nonspecific staining or autofluorescence of cell wall and intracellular components, made it difficult to draw firm conclusions of significance. Thus, additional analyses will be needed to prove or disprove current PCD theories. Nevertheless, the differences in TUNEL and PI signals across fiber development stages indicate that the observed fluorescence patterns are marking discrete developmental phases. The PI signal is dispersed throughout the cell during the elongation phase (5-15 DPA) and appears to condense during secondary cell wall synthesis (25- 40 DPA). TUNEL-positive signal may be observed as early as 25 DPA, but the signal is not widespread until 45 DPA. At 50 DPA and beyond, PI staining is reduced. Visually detectable DNA can be extracted from cotton fiber nuclei between 5 and 40 DPA, although a laddering pattern was not visible at any time-point. The results, although inconclusive, point to the possibility that PCD may be a process leading to maturation in the cotton fiber, succeeding completion of secondary cell wall synthesis.

Investigations of Fas- and chemotherapy induced apoptosis in Jurkat T-cells using MRS

Al-Saffar, Nada M. Salman January 2002 (has links)
No description available.

Mechanisms of Zn2+- and excitotoxin-induced oligodendrocyte progenitor cell injury

Kelland, Eve Emily January 2003 (has links)
1. The present study examined whether primary cultured rat A2B5+ cerebrocortical oligodendrocyte progenitor cells (OPC) were susceptible to Zn2+- and excitotoxin-induced cell death. 2. Initial pharmacological studies demonstrated the selective ionotropic glutamate receptor agonists' kainate and (S)-5-Iodowillardiine induced OPC death after 24-hour exposure. (S)-AMPA and L-glutamate only induced cell death in the presence of 100muM cyclothiazide (a selective AMPA receptor desensitisation blocker). The selective AMPA- receptor antagonists, GYKI 52466 and Evans' Blue, attenuated 300muM kainate-induced toxicity and therefore suggested OPC excitotoxic insult was via AMPA receptor activation. 3. Metabotropic glutamate receptor (mGluR) involvement was also established as (S)-DBPG (100muM), a selective group I mGluR agonist, afforded significant (p < 0.05) protection against 300muM kainate-induced toxicity. The selective mGIuR antagonist (S)-MCPG reversed the effects of (S)-DHPG protection. 4. OPC death was partially prevented by the broad-spectrum caspase inhibitor Z-VAD-fmk (100muM) at 6-hour and 24-hour paradigms. Hoechst 33342 staining revealed the presence of pyknotic nuclei following 6-hour kainate (300muM) exposure and Western Blotting using anti-caspase-3 antibody and anti-a-fodrin antibody indicated potential activation of the apoptotic executioner caspase-3. 300muM Kainate-induced OPC death did not appear to result in the activation of reactive oxygen species (ROS). 5. Zn2+ exposure over 24-hours resulted in OPC death (pECso 4.1+0.1). 100muM Zn2+- induced OPC death was not potentiated by 300muM kainate and Evans Blue afforded no protection. Nicardipine also failed to influence OPC viability. The lack of effect of kainate and nicardipine was confirmed by 65Zn2+ uptake studies. 6. 100muM and 300muM Zn2+-induced OPC death did not appear to result in activation of ROS. Hoechst 33342 staining revealed the presence of chromatin condensation with 300muM Zn2 (6-hour exposure). 100|muM and 300muM Zn2+ (24-hour exposure) was not influenced by Z-VAD-fmk or PD 150606. 7. Zn2+-induced OPC toxicity resulted in significant ATP depletion 6-hours following 300muM Zn2+ exposure (p < 0.05) and was attenuated in the presence of 5mM pyruvate. These data therefore suggest the mechanisms of Zn2+ toxicity may involve disruption of the glycolytic cascade.

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