As a racecar negotiates a track, it is subjected to many inputs at both high and low frequencies. These inputs come from the track surface, the motion of the body, and from aerodynamic disturbances. The damper's ability to control these inputs leads to improved grip at the tires, which increases overall handling of the vehicle. Since dampers have always been assumed to be primarily velocity dependent, little work has gone into exploring damper's frequency dependent nature. Therefore, this study evaluates the effect input frequency has on the damper's output force. Utilizing experimental testing, with a state of the art damper dynamometer, and computer simulation with a parametric damper model developed for this study, several inputs and key parameters are tested, and the damper's frequency dependent nature starts to emerge. Constant peak velocity sinusoidal and sinusoidal sweep inputs are used for the experimental testing. The results show that as the input frequency is increased, the damper's output force lissajou transitions from the characteristic shape of a damper's lissajou to a shape characteristic of a spring's lissajou. This change in the lissajou is linked to hysteretic effects, which includes the gas spring effect. Damper parameters that are suspected to contribute to the hysteretic effects are explored with computer simulation and additional experimental testing. The results from this show that fluid preparation, fluid type, initial gas pressure, and friction have a predictable effect on the damper's output force. / Master of Science

Tuberculosis, caused by Mycobacterium tuberculosis (MTB), is a common and potentially lethal infectious human disease. Rifampicin is a front line anti-tuberculosis drug usually prescribed in combination with isoniazid, pyrazinamide and streptomycin for a period of six to seven months. When given orally for the treatment of MTB, rifampicin exhibits low bioavailability. Recent attempts to increase bioavailability and decrease dosage of anti-tuberculosis drugs have focused on creating polymer coated rifampicin nanoparticles. The research effort presented in this thesis evaluates the formation, characterization and relative bioavailability of rifampicin loaded carboxymethylcellulose acetate butyrate (CMCAB) particles using two different formulation techniques. Multi inlet vortex mixer (MIVM) and manual spray drying techniques were used to form the rifampicin containing CMCAB particles. Characterization studies and analyses of particles revealed differences in particle sizes, shapes and drug loading between the different particle formulation techniques. In vivo pharmacokinetic studies in BALB/c mice indicate that a single dose of rifampicin laden CMCAB spray dried particle formulations are able to improve pharmacokinetic parameters including relative bioavailability of rifampicin compared to that of the free drug form at the same concentration. / Master of Science

Ionomeric polymer transducers (IPTs) are an exciting new class of smart materials that can serve a dual purpose in engineering or biomedical applications as sensors or actuators. Most commonly they are used for mechanical actuation, as they have the ability to generate large bending strains and moderate stress under low applied voltages. Although the actuation capabilities of IPTs have been extensively studied, the sensing capabilities of these transducers have yet to be fully explored. The work presented herein aims to investigate the fundamental sensing characteristics of these transducers and apply the acquired knowledge toward the development of an electronic stethoscope for digital auscultation. The sensors were characterized both geometrically and electrically to determine their effectiveness in resolving a signal from sub 1 Hz to 2 kHz. Impedance spectroscopy was used to interrogate the sensing mechanism. Following the characterization of the transducer, a bio–acoustic sensor was designed and fabricated. The bio–acoustic sensor was placed over the carotid artery to resolve the arterial pressure waveform in situ and on the thorax to measure the S1 and S2 sounds generated by the heart. The temporal response and spectral content was compared with previously known data and a commercially available electronic stethoscope to prove the acquisition of cardiovascular sounds. / Master of Science

Water treatment facilities commonly reduce soluble contaminants, such as soluble manganese (Mn2+), in water by oxidation and subsequent filtration. Previous studies have shown that conventional porous filter system removes Mn2+ from drinking water by developing Mn-oxides (MnOx(s)) bearing coating layers on the surface of filter media. Multiple models have been developed to explain this Mn2+ removal process and the formation mechanism of MnOx(s) coatings. Both, experimental and theoretical studies to date have been largely focused on the micrometer to millimeter scale range; whereas, coating layers are composed of nanoscale particles and films. Hence, understanding the nanoscale particle and film formation mechanisms is essential to comprehend the complexity of soluble contaminant removal processes. The primary objective of this study was to understand the initial MnOx(s) coating formation mechanisms and evaluate the influence of filter media characteristics on these processes. We pursued this objective by characterizing at the micro and nanoscale MnOx(s) coatings developed on different filter media by bench-scale column tests with simulating inorganic aqueous chemistry of a typical coagulation fresh water treatment plant, where free chlorine is present across filter bed. Analytical SEM and TEM, powder and synchrotron-based XRD, XPS, and ICPMS were used for characterization of coatings, filter media and water solution elemental chemistry. A secondary objective was to model how surface coating formation occurred and its correlation with experimentally observed physical characteristics. This modeling exercise indicates that surface roughness and morphology of filtering media are the major contributing factors in surface coating formation process. Contrary to previous models that assumed a uniform distribution and growth of surface coating, the experimental results showed that greater amounts of coating were developed in rougher areas. At the very early stage of coating formation, unevenly distributed thin films and/or particle aggregates were observed, which provided active sites for further surface coating growth. The predominant MnOx(s) phase in the surface coatings was identified to be poorly crystalline birnessite having scavenging activity by intercalation and/or sorption. This would explain the enhancement of efficiency in removing soluble manganese and other contaminants during water filtration. Moreover, the increased Mn2+ removal effect of having aluminum (Al) in pre-treated water is explained. These results indicate that the surface roughness and morphology need to be incorporated into particle capture models to more precisely describe the soluble manganese removal process. / Ph. D.

Magnetorheolgical (MR) fluid dampers have the capability of changing their effective damping force depending on the current input to the damper. A number of factors in the construction of the damper, as well as the properties of the fluid and the electromagnet, create a dynamic response of the damper that cannot be fully described with a static model dependent on current and velocity. This study will compare different techniques for modeling the force response of the damper in the current-velocity space. To ensure that all the dynamic response characteristics of the damper are captured in data collection, random input signals were used for velocity and current inputs. By providing a normally distributed random signal for velocity to a shock dynamometer and a uniformly distributed random signal for current to a Lord rheonetic seat damper, the force response could be measured. The data from this test is analyzed as a two dimensional signal, a three dimensional force plot in the current velocity plane, and as a probability density function. Four models are created to fit the data. The first is a linear model dependent solely on current. The second is a nonlinear model dependent on both current and velocity. The third model takes the nonlinear model and includes a filter that affects the force response of the model with time. Each of these three approaches are compared based on the total error in the force response and the models? ability to match the PDF of the data. Finally, a fourth model is created for the damper that improves the nonlinear model by making one parameter a probability parameter defined by a PDF calculated from the data. However, because it is a probability model, the error cannot be found through comparison to the data. / Master of Science

Silicon carbide (SiC) is a wide bandgap material capable of higher voltage and higher temperature operation compared to its silicon (Si) counterparts due to its higher critical electric field (E-field) and higher thermal conductivity. Using SiC, MOSFETs with a theoretical high temperature operation and reliability is achievable. However, current bottlenecks in high temperature SiC MOSFETs lie within the limitations of standard packaging. Additionally, there are reliability issues relating to the gate oxide region of the MOSFET, which is exacerbated through high temperature conditions. In this thesis, high temperature effects on current-generation SiC MOSFETs are studied and analyzed. To achieve this, a high temperature package is created to achieve reliable operation of a SiC MOSFET at junction temperatures of 300 °C. The custom, high temperature package feasibility is verified through studying trends in SiC MOSFET behavior with increasing temperature up to 300 °C by static characterization. Additionally, the reliability of SiC MOSFETs at 300 °C is tested with accelerated lifetime bias tests. / M.S. / Electrical devices that are rated for high temperature applications demand a use of a material that is stable and reliable at the elevated temperatures. Silicon carbide (SiC) is such a material. Devices made from SiC are able to switch faster, have a superior efficiency, and are capable of operating at extreme temperatures much better than the currently widely used silicon (Si) devices. There are limitations on SiC certain structures of SiC devices, such as the metal oxide semiconductor field effect transistor (MOSFET), have inherent reliability issues related to the fabrication of the device. These reliability issues can get worse over higher temperature ranges. Therefore, studies must be made to determine the feasibility of SiC MOSFETs in high temperature applications. To do so, industry standard tests are conducted on newer generation SiC MOSFETs to ascertain their use for said conditions.

The development of label-free optical biosensors is motivated by the need for highly accurate and sensitive measurements of biomolecular interactions. The Interferometric Reflectance Imaging Sensor (IRIS) delivers precise and multiplexed detection of such interactions. A significant challenge in label-free sensing is the bulk effect, which is the presence of unwanted signals caused by variations in refractive index that can obscure true binding interactions and lead to inaccurate measurements. This thesis presents multiple advancements to IRIS technology focusing on the quantitative detection and elimination of the bulk effect using the principles of light reflection in different colors. A novel bulk-effect-free signal calculation method is introduced, significantly reducing sensitivity to refractive index variations. Additionally, a methodology for real-time detection of changes in refractive index is developed. Both systems are theoretically validated through MATLAB simulations. Experiments were conducted to demonstrate the effectiveness of the bulk-effect- free signal measurement and the refractive index detection system. Two main types of experiments were performed: with solutions of varying refractive indices without actual binding to detect refractive index changes and binding experiments to test new systems' effectiveness in detecting true biomolecular interactions. Novel experimental procedures using a combination of these methods were introduced to eliminate the bulk effect. This thesis establishes the foundation for the next-generation multicolor IRIS system, enhancing its potential for accurately detecting biomolecular interactions by eliminating the bulk effect and incorporating refractive index detection. / 2026-09-10T00:00:00Z

Yes / In order to investigate the effect of using different solid state forms and specific surface area (TBET) of active pharmaceutical ingredients on tabletability and dissolution performance, the mono- and dihydrated crystalline forms of chlorothiazide sodium and chlorothiazide potassium (CTZK) salts were compared to alternative anhydrous and amorphous forms, as well as to amorphous microparticles of chlorothiazide sodium and potassium which were produced by spray drying and had a large specific surface area. The tablet hardness and tensile strength, porosity, and specific surface area of single-component, convex tablets prepared at different compression pressures were characterized. Results confirmed the complexity of the compressibility mechanisms. In general it may be concluded that factors such as solid-state form (crystalline vs amorphous), type of hydration (presence of interstitial molecules of water, dehydrates), or specific surface area of the material have a direct impact on the tabletability of the powder. It was observed that, for powders of the same solid state form, those with a larger specific surface area compacted well, and better than powders of a lower surface area, even at relatively low compression pressures. Compacts prepared at lower compression pressures from high surface area porous microparticles presented the shortest times to dissolve, when compared with compacts made of equivalent materials, which had to be compressed at higher compression pressures in order to obtain satisfactory compacts. Therefore, materials composed of nanoparticulate microparticles (NPMPs) may be considered as suitable for direct compaction and possibly for inclusion in tablet formulations as bulking agents, APIs, carriers, or binders due to their good compactibility performance / Solid State Pharmaceutical Cluster (SSPC), supported by Science Foundation Ireland under Grant No. 07/SRC/B1158.

This thesis presents the conducted electro-magnetic interference (EMI) prediction results for a continuous conduction mode (CCM) power factor correction (PFC) converter as well as the theoretical analysis for the noise generation and propagation mechanisms. In this thesis, multiple modeling and characterization techniques in the medium and high frequency ranges are developed for the circuit components that are important contributors to the EMI noise, so that a detailed simulation circuit for EMI prediction can be constructed. The conducted EMI noise prediction from the simulation circuit closely matches the measurement results obtained by a spectrum analyzer. Simulation time step and noise separator selection are two important issues for the noise simulation and measurement. These two issues are addressed and the solutions are proposed. The conducted EMI generation and propagation mechanisms are analyzed in a systematic way. Two loop models are proposed to explain the EMI noise behavior. The effects of the PFC inductor, the parasitic capacitance between the device and the heatsink, the rising/falling time of the MOSFET VDS voltage, and the input wires are studied to verify the validity of the loop models. / Master of Science

Graphite foams have high bulk thermal conductivity and low density, making them an excellent material for heat exchanger applications. This research focused on the characterization of graphite foams under various processing conditions (different foaming pressures and particle additions), specifically studying the effects of porosity on the thermal properties. The characterization of the foams included measuring cell sizes, percent open porosity, number of cells per square inch, bulk density, Archimedes density, compression strength, thermal conductivity, thermal resistance, and permeability. Several relationships between the structure and properties were established, and a recommendation for the processing conditions of graphite foams for the use in heat exchangers was determined. / Master of Science