by Sun Wai-Lee. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references (leaves [74-76]). / APPROVAL --- p.II / ACKNOWLEDGMENTS --- p.III / ABSTRACT --- p.IV / TABLE OF CONTENT --- p.VI / LIST OF FIGURES --- p.IX / LIST OF TABLES --- p.X / Chapter CHAPTER I --- Introduction --- p.1 / Background --- p.1 / Organization of the paper --- p.2 / Relevance of the study to Hong Kong --- p.3 / Scope --- p.4 / Chapter CHAPTER II --- Red Chips and H Shares --- p.5 / Chapter Section 2.1: --- The characteristics of Red Chips and H Shares --- p.5 / Background --- p.5 / Sector Distribution --- p.9 / Price Earning (P/E) Ratio --- p.11 / Different Aspects of Red Chips and H Shares --- p.13 / Chapter Section 2.2: --- Red Chips --- p.15 / Background --- p.15 / The Hang Seng China-Affiliated Corporations Index (HSCCI) --- p.15 / Market Capitalization --- p.17 / Listing Methods --- p.19 / Main Features of Red Chips --- p.22 / Chapter Section 2.3: --- H Shares --- p.25 / Background --- p.25 / The Hang Seng China Enterprises Index (HSCEI) --- p.25 / Market Capitalization --- p.26 / Listing Aspects --- p.28 / Main Features of H Shares --- p.30 / Chapter CHAPTER III --- Risk and Return Characteristics --- p.31 / Chapter Section 3.1: --- Literature Review --- p.31 / Measurement of Risk --- p.31 / Chapter Section 3.2 --- Methodology --- p.37 / All Ordinaries Index --- p.38 / Data Collection and Empirical Work --- p.40 / Constraints --- p.40 / Chapter CHAPTER IV --- The Results --- p.41 / Chapter Section 4.1 --- Index Performance --- p.41 / Chapter Section 4.2 --- Findings on systematic risks --- p.43 / Comparison between Red Chips and H Shares --- p.43 / Individual Red Chips --- p.47 / Individual H Shares --- p.48 / Sectoral portfolios of Red Chips --- p.50 / Sectoral portfolios of H Shares --- p.53 / Chapter "Section 4,3 " --- Risk and Return Relationship --- p.54 / Chapter CHAPTER V --- Conclusions --- p.59 / RECOMMENDATIONS FOR FURTHER RESEARCH --- p.61 / APPENDICES / BIBLIOGRAPHY

published_or_final_version / Literary Studies / Master / Master of Arts

published_or_final_version / Architecture / Master / Master of Architecture

published_or_final_version / Architecture / Master / Master of Architecture

published_or_final_version / Architecture / Master / Master of Architecture

published_or_final_version / Literary and Cultural Studies / Master / Master of Arts

Clinical evidence suggested patients with lower plasma C-reactive protein (CRP) levels after statin therapy could have better clinical outcome. The last part of the study was to measure on-treatment high sensitivity CRP (hsCRP) levels among 229 Chinese patients with hyperlipidaemia undergoing treatment with simvastatin 40 mg daily. The patients were genotyped for 15 SNPs or haplotypes in 11 candidate genes that would have significant allele frequency among Chinese patients and may be linked to statin efficacy or hsCRP levels. The analysis suggested BMI is the largest single contributing factor of 15.0% of the variation in hsCRP levels, followed by plasma triglycerides levels contributing 4.7% and male gender 1.6% (all P<0.05). However comparisons of hsCRP levels among genotype groups did not reveal any significant findings, with or without adjustment with covariate genotypic or phenotypic factors. To further categorize individuals as high or medium risk, we set a threshold hsCRP level of 1 mg/L as the benchmark for evaluation. The CRPc.3872G>A SNP was related to lower risk compared to the homozygous wild-type genotype (adjusted odds ratio AOR = 0.289; P = 0.014) after adjusting for phenotypic factors of age, gender, smoking status, BMI, waist circumference, hip circumference, plasma lipid profiles, co-existing disease and co-medications. Another marginal finding included the HNF1A c.79A>C SNP (AOR = 0.575; P = 0.118). / Polymorphisms in the drug transporters are likely to be more important with hydrophilic statins such as pitavastatin, which undergoes transporter mediated distribution. The SLCO1B1 c.388A>G polymorphism in the gene encoding the uptake transporter organic anion transporting polypeptide (OATP1B1) is common in Chinese and the variant was associated with increases of 63--68% in maximum plasma concentration and 44--47% in systemic exposure of both the lactone and acid compared to wild-type subjects (P<0.05). Co-administration of pitavastatin with grapefruit juice (GFJ) resulted in a small increase of the area under the plasma concentration time curve (AVC) by 15--16% for both the acid and lactone (P<0.05). However, there was no significant effect on the drug-food interaction in relation to relevant SNPs in the enzymes and transporters examined. / The SNPs examined included those in the genes for the enzymes and transporters involved in the metabolic pathway or the distribution of simvastatin. Cytochrome P450 (CYP) enzymes are involved in hepatic and intestinal metabolism of several statins and simvastatin is known to undergo extensive metabolism via the CYP3A4/3A5 pathway. The common candidate SNPs in the CYP3A4/3A5 enzymes found in Chinese populations include CYP3A4*1G, CYP3AP1*3 and CYP3A5*3 , which are associated with altered enzyme expression and activity. However, no statistically significant relationship was found between these SNPs and a potential phenotypic marker of enzyme activity, the urinary ratio of 6beta-hydroxy-cortisol/cortisol (6beta-OHC/C) concentrations. The analysis of lipid lowering responses in relation to individual SNPs or combinations from gene-gene interactions also revealed no statistically significant findings. In the subgroup of patients with familial hypercholesterolaemia, the CYP3A4*1G, CYP3AP1*3 and CYP3A5*3 polymorphisms appeared to have a small effect on the changes in LDL-C and total cholesterol with the subjects with the CYP3A5*3 and CYP3AP1*3 variants showing less reduction and those with the CYP3A4*1G variant showing more reduction than subjects with the wild-type genotype with a tendency for a gene-dose effect. It is difficult to interpret these findings and the significance may be related to multiple testing. / The statins, or 3-hydroxymethyl-3-glutaryl coenzyme A (HMG-CoA) reductase inhibitors, act on the rate limiting step in endogenous cholesterol synthesis. Their primary action results in reduction of plasma low-density lipoprotein cholesterol (LDL-C) levels and this is thought to be the major mechanism by which they reduce cardiovascular events. There are considerable differences between subjects in both the plasma levels of the statins and in their effects on LDL-C and other lipid parameters and some of this variation appears to be related to genetic differences in the pathways of drug metabolism and distribution and in the pathways involved in lipid metabolism. / The variation in response may be related to variations in systemic or hepatic exposure to the drug, which in turn will be related to the pharmacokinetics. This is also likely to play a role in the adverse effects of myopathy and therapeutic tolerance. In a pharmacokinetic study in healthy male Chinese subjects, the common polymorphism of CYP2D6*10 was analyzed in relation to the pharmacokinetics of lovastatin and simvastatin. There was a tendency for reduced clearance of simvastatin lactone by 30% (P>0.05) in subjects with the CYP2D6*10/*10 genotype. With lovastatin, there were similar findings with 38.5--84.9% decrease in clearance which appeared to be related to enzyme activity according to genotype, with *5 carriers showing a greater decline in clearance than *10 carriers (P<0.05). / These results provide some insights into the pharmacokinetics and pharmacodynamics of statins and the pharamacogenetic relationships to candidate SNPs. Future research in this field should help to facilitate safer and more effective treatment with these commonly used medications, resulting in personalized therapy and optimal clinical benefits for patients with cardiovascular disease. / This thesis describes a study of 270 patients recruited from the outpatient clinics at the Prince of Wales Hospital who were treated with simvastatin 40 mg daily for at least 4 weeks. Their mean (+/-SD) LDL-C baseline level was 5.38+/-1.68 mmol/L and the reduction in LDL-C after simvastatin treatment was 2.81+/-0.99 mmol/L or -47.1+/-12.5%. / Mak, Wah Lun Valiant. / Adviser: Brian Tomlinson. / Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 253-289). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.

A mixed-methods design consisting of two phases was adopted. In Phase I, a purposive sample of 31 older Clnnese people with KOA was invited for a semi-structured interview to explore their perceptions and experiences of exercise. Five major categories emerged: typical living pattern with KOA, self-management of KOA, the practice of exercise, views about exercise, and preferences for learning exercise. The findings were used in the development of an exercise programme for this client group. / Knee osteoarthritis (KOA) is prevalent in the growing older Chinese population in Hong Kong. Therapeutic exercise for KOA has strong empirical evidence of its effectiveness on reducing knee pain and physical disability in people with KOA provided that they persists in practising the recommended exercise regimen. However, few previous studies have incorporated the client's perspectives into the design of an exercise programme for promoting continual practice of exercise. This study aimed to develop a new therapeutic exercise programme and pilot its acceptability to promote continual practice for older Chinese people with KOA. / The Phase II study used both quantitative and qualitative approaches to examine participants' satisfaction with the new exercise programme, adherence to the prescribed exercises, mastering of the exercise movements and health outcomes (knee pain, stiffness and range-of-motion, physical function, muscle strength and endurance of the lower extremities, and quality of life). A convenience sample of 33 older Chinese people with KOA participated in the programme. Seven measurement tools in Chinese versions (if applicable) were used to collect quantitative data from the participants: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the 12-item Short Form of the Medical Outcome Study Questionnaire (SF-12), a goniometer, the Timed-Stands Test (TST), a satisfaction questionnaire, an exercise diary, and a return-demonstration performance record sheet. Six of the participants were invited for a semi-structured interview to explore their experience of the programme. / The quantitative results showed that the participants were highly satisfied with the exercise programme with a mean score of 90.15 out of 100 (SD = 8.05). Their average exercise adherence was high with a mean percentage of 91.04% (SD = 14.54) and their overall performance in mastering of the exercise movements was good with a mean score of 76.71 out of 100 (SD = 21.75). Most participants' health outcomes significantly improved at three months after the exercise programme, except for the SF-12 physical health summary score. The qualitative findings revealed four major categories: satisfaction with the exercise programme, mastering of the exercise movements, experience of the exercise's effects, and integration of the exercises into the daily routine. These findings were mainly consistent with the quantitative results of the study. / The results of this study showed that the exercise programme was acceptable to the participants in terms of satisfaction with the programme, adherence to the prescribed exercises and mastering of the exercise movements. Therefore, adopting a client-centred approach is likely to be a way forward in the development of exercise programmes for promoting continual practice of therapeutic exercise regimens by older Chinese people with KOA. / Lee, Fung Kam. / Advisers: Tak Ying Ann Shiu; Tze Fan Diana Lee; Kwok Wei Winnie So. / Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 332-369). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese; some appendixes in Chinese.

Auditory sensitivity was associated with speech perception which influenced Chinese word reading mainly through morphological awareness and rapid automatized naming. In contrast, for English word reading, the best model required an additional direct path from suprasegmental sensitivity (in Chinese) to English word reading on the basis of the proposed model. To be specific, auditory sensitivity was fully mediated by segmental and suprasegmental speech perception which further impacted English word reading mainly through phonological awareness; in addition, suprasegmental perception or speech prosody (in Chinese) was directly associated with word reading. Third, stress sensitivity in English was highly associated with speech prosodic sensitivity in Chinese. Hierarchical regressions also showed that suprasegmental speech perception failed to account unique variance for English word reading beyond phonological awareness when stress sensitivity was further controlled, suggesting that Chinese suprasegmental speech sensitivity may influence English word reading at least partly through its overlap with stress sensitivity. / This study investigated the associations of auditory sensitivity, speech perception, Chinese reading as a first language (L1) and English reading as a second language (L2) in Hong Kong Chinese children. Participants were 180 second and third graders (98 boys and 82 girls, mean age=98.6months). Apart from auditory sensitivity (both temporal and rhythmic processing measures), English stress sensitivity and English word reading, children were also tested on Chinese tasks of speech perception (both segmental and suprasegmental tasks), phonological awareness, rapid automatized naming (digit), verbal short-term memory, morphological awareness and Chinese word reading. I proposed a four-stage model, in which auditory sensitivity is fully mediated by speech perception at both the segmental and suprasegmental levels. These further impact word reading through phonological awareness, rapid automatized naming, verbal short-term memory and morphological awareness. A series of nested model comparisons were conducted to test this model for both Chinese and English word reading using structural equation modeling. For Chinese word reading, the proposed four-stage model was demonstrated to be the best model. / Zhang, Juan. / Advisers: Catherine A. McBride-Chang; Him Cheung. / Source: Dissertation Abstracts International, Volume: 73-06, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 103-118). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.

by Cheng To-shun, Yan Kai-cheung. / Summary in Chinese. / Thesis (M.B.A.)--Chinese University of Hong Kong, 1984. / Bibliography: leaves 97-98.