Spelling suggestions: "subject:"cholesterol,"" "subject:"eholesterol,""
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Supporting data analysis and the management of uncertainty in knowledge-based systems through information aggregation processesSchuster, Alfons January 1998 (has links)
No description available.
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Influence of cardiovascular risk factors on exercise blood pressureBrett, Sally Emma January 2001 (has links)
No description available.
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Modulation of potassium channels in isolated rabbit aortic myocytesHalliday, Fiona Catherine January 1996 (has links)
No description available.
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Mortality and morbidity from coronary heart disease, diabetes and hypertension in women with polycystic ovary syndrome at long-term follow-upWild, Sarah Helen January 2000 (has links)
No description available.
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Contaminants in food stuffsLu, Qian January 1997 (has links)
No description available.
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The role of metal ions in LDL peroxidationCrabtree, Elaine January 1997 (has links)
No description available.
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Dietary saturated fatty acids and lipoprotein metabolism in the hamsterBruce, Jennifer S. January 1996 (has links)
No description available.
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A biomimetic approach to CP-225,917 and CP-263,114Cox, Rhona J. January 2001 (has links)
No description available.
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A clinical chemistry-based epidemiological study of the main causes of myocardial infarctionClark, Sarah A. January 1997 (has links)
No description available.
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Genetic variants affecting responses of plasma lipids and cholesterol kinetics to dietary cholesterol versus plant sterol consumption in a founder populationAlphonse, Peter AS 30 November 2015 (has links)
Lowering plasma LDL-cholesterol (LDL-C) and increasing HDL-cholesterol (HDL-C) concentrations remain the primary targets in cardiovascular disease (CVD) risk reduction. Dietary cholesterol and plant sterols differentially modulate cholesterol kinetics and lipoprotein distribution. Inter-individual variations in the rates of cholesterol absorption and synthesis, and the reciprocal interaction between them affect the responses to dietary sterols. Genetic heterogeneity profoundly influences such responsiveness. However, limited research exists on the genetic determinants of dietary cholesterol versus plant sterols responsiveness in healthy individuals, especially in a founder population, such as the Hutterites in Manitoba of European descent who practice a communal living system. Our study examined the differential effects of dietary cholesterol versus plant sterol consumption on plasma lipoprotein levels, subclasses, and cholesterol kinetics and assessed how genetic variants influenced these responses. A double-blind, randomized, crossover study with three interventional periods of 4 wk duration each was conducted. Healthy Hutterite individuals (n=49) from Manitoba consumed daily either 2 g of plant sterols or 600 mg of cholesterol incorporated into milkshakes, or a placebo during each period. Plasma lipid profile and lipoprotein subclass distribution were determined. Cholesterol absorption and synthesis were assessed by stable isotopic tracer techniques. Participants were genotyped for 38 candidate single nucleotide polymorphisms across 25 genes involved in cholesterol and lipoprotein metabolism. Dietary cholesterol consumption increased plasma TC, HDL-C concentrations and large HDL subclasses with no changes in cholesterol absorption or synthesis. In contrast, plant sterol intake failed to reduce LDL-C concentrations, with a modest reduction in cholesterol absorption, and did not affect lipoprotein subclasses. However, a large non-compensatory increase in cholesterol synthesis was observed due to plant sterol consumption. Gender and common genetic variants affected plasma HDL-C and HDL subclass distribution to dietary cholesterol and plant sterol consumption. ACAT2 and NPC1L1 gene variants affected plasma campesterol and β-sitosterol concentrations respectively, to plant sterol intake by modifying cholesterol absorption. In summary, our results demonstrate that dietary cholesterol and plant sterol intake differentially modulate cholesterol trafficking in a manner dependent on common genetic variants and gender in healthy individuals. Such knowledge facilitates the development of effective cholesterol lowering strategies for the alleviation of CVD burden. / October 2016
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