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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.094 seconds)Spelling suggestions: "subject:"choroidal revascularization (CNV)"" "subject:"choroidal vascularization (CNV)""
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Immunosenescence in Choroidal Neovascularization (CNV): Transcriptional Profiling of Naïve and CNV-Associated Retinal Myeloid Cells during AgingSchlecht, Anja, Thien, Adrian, Wolf, Julian, Prinz, Gabriele, Agostini, Hansjürgen, Schlunck, Günther, Wieghofer, Peter, Boneva, Stefaniya, Lange, Clemens 02 February 2024 (has links)
Immunosenescence is considered a possible factor in the development of age-related macular
degeneration and choroidal neovascularization (CNV). However, age-related changes of myeloid
cells (MCs), such as microglia and macrophages, in the healthy retina or during CNV formation are illdefined.
In this study, Cx3cr1-positive MCs were isolated by fluorescence-activated cell sorting from
six-week (young) and two-year-old (old) Cx3cr1GFP/+ mice, both during physiological aging and
laser-induced CNV development. High-throughput RNA-sequencing was performed to define the
age-dependent transcriptional differences in MCs during physiological aging and CNV development,
complemented by immunohistochemical characterization and the quantification of MCs, as well as
CNV size measurements. These analyses revealed that myeloid cells change their transcriptional
profile during both aging and CNV development. In the steady state, senescent MCs demonstrated
an upregulation of factors contributing to cell proliferation and chemotaxis, such as Cxcl13 and Cxcl14,
as well as the downregulation of microglial signature genes. During CNV formation, aged myeloid
cells revealed a significant upregulation of angiogenic factors such as Arg1 and Lrg1 concomitant
with significantly enlarged CNV and an increased accumulation of MCs in aged mice in comparison
to young mice. Future studies need to clarify whether this observation is an epiphenomenon or a
causal relationship to determine the role of immunosenescence in CNV formation.
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| 2 |
The Effects of Lactate Receptor G Protein-Coupled Receptor 81 (GPR81) on the Integrity of the Choroidal VasculatureYang, Xiaojuan 02 1900 (has links)
No description available.
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