This dissertation explores the integration and optimization of advanced communication technologies within the collaborative mobile system (CMS), focusing on the system design, implementation, and evaluation over unmanned aerial vehicles (UAVs). Collectively, this dissertation tackles the key challenges of connectivity and performance within CMS. This work demonstrates practical implementations and sheds light on the challenges and opportunities for CMS. The dissertation emphasizes the importance of adaptability and scalability in network design and implementation, particularly in leveraging the integration of hardware and software to adapt to promising architectures. By providing insights into performance under real-world conditions, this work explores the interplay of innovations in UAVs, mobile communications, network architecture, and system performance, paving the way for future network investigation and development.