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The effect of a diminished folate status on colorectal carcinogenesis / by Richard Le Leu.Le Leu, Richard K. January 2000 (has links)
Errata pasted onto t.p. verso. / Bibliography: leaves 129-148. / 148 leaves : [3] col. ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Investigates the relationship between folate states and colorectal cancer risk using the rat AOM intestinal cancer model. Results indicate that folate status can play an important role in modulating colorectal carcinogenesis. / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2000
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Predictors of response to adjuvant chemotherapy for colorectal cancer.Thomas, Michelle Liza January 2010 (has links)
Background: It is well recognized that not all patients with stage C colorectal cancer (CRC) derive a survival benefit from adjuvant chemotherapy. It would therefore be advantageous to identify factors that define a target group for treatment. It has been suggested that those most likely to benefit are women with proximal tumours. Recent work has suggested microsatellite instability (MSI) may be a useful marker however the limited studies performed are conflicting. Aim: To determine if gender, site, tumour histology or microsatellite (MSI) status predict survival benefit from 5FU-based adjuvant chemotherapy in stage C CRC. Method: Data was collated on stage C colorectal cancer cases that underwent curative resection over a 20-year period (inclusive of years prior to standard chemotherapy). Pathology was re-evaluated, DNA extracted from the formalin fixed paraffin specimen and MSI status established. Primary endpoint was cancer-related death. Kaplan-Meier curves were constructed for univariate analysis and differences analysed by log rank test. Multivariate analysis was performed using Cox proportional hazard model adjusting for age, gender, site, distinct pathological variables and MSI. A compounding effect between these factors and chemotherapy benefit was measured by interaction testing Results: 811 unselected cases were included in the study. Thirty-seven percent received chemotherapy. Chemotherapy significant improved cancer-specific survival (HR of dying 0.66 (95% CI 0.52-0.83 p=0.0003). Female gender offered a survival advantage overall (HR 0.81 95% CI 0.68-0.97; p=0.02) however site did not influence outcome (HR 1.03). On interaction testing, gender, site and tumour histology did not significantly influence the survival effect of chemotherapy. 802 cases were included in the MSI analysis of which 77 exhibited MSI. MSI status did not influence prognosis (HR of cancer death 1.45, 95% CI 0.90-2.21; p= 0.13). However, in the non-chemotherapy cohort, MSI conferred a significantly less favourable outcome (HR 1.89, 95%CI 1.13-3.16; p= 0.02). Chemotherapy produced a survival benefit in both the MSI (HR 0.08 95% CI 0.02-0.27; p=<0.0001) and the microsatellite stable (MSS) cohort (HR 0.62, 95% CI 0.47-0.81; p=0.001). On interaction testing, neither compounded the benefit of chemotherapy, however of all the tested parameters, MSI came closest to significance (p=0.08). Conclusion: These results suggest that 5FU-based adjuvant chemotherapy for stage C colorectal cannot be targeted using gender, tumour site, histological characteristics or MSI. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1522132 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2010
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Application of Magnetic Resonance Spectroscopy in Tumor PathologyRekas, Agata January 1999 (has links)
No description available.
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Optimistically biased colon cancer risks motivational causes and consequences /DiBonaventura, Marco daCosta. January 2007 (has links)
Thesis (Ph. D.)--Rutgers University, 2007. / "Graduate Program in Psychology." Includes bibliographical references (p. 70-74).
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Calcium-induzierte Chloridsekretion an isolierten Krypten aus dem Kolon der RatteHennig, Britta. January 2007 (has links)
Universiẗat, Diss., 2007--Giessen.
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Calcium-induzierte Chloridsekretion an isolierten Krypten aus dem Kolon der Ratte /Hennig, Britta. January 2007 (has links)
Universiẗat, Diss., 2007--Giessen.
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Molecular detection and significance of circulating colorectal cancer cells /Hardingham, Jennifer E. January 1998 (has links) (PDF)
Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1999. / Bibliography: leaves 214-236.
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Studies on genetic markers and in particular nm23 in sporadic colorectal cancer : predictors of liver metastasis /Berney, Christophe R. January 1999 (has links)
Thesis (Ph. D.)--University of New South Wales, 1999. / Also available online.
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Modeling racial differences in colorectal cancer screening : evidence from a nationally representative sample /Ehrensberger, Ryan J., January 2007 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for : School of Education. Bibliography: leaves 100-112. Also available online via the Internet.
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Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survivalMcEwan, David George. January 2007 (has links)
Thesis (Ph.D.) - University of Glasgow, 2007. / Thesis submitted in part fulfilment of the Ph.D. to The Beatson Institute for Cancer Research, Faculty of Medicine, University of Glasgow, 2007. Includes bibliographical references. Print version also available.
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