Due to the combined effect of intense rainfall events together with the expected impact of climate change, this will put pressure on the existing and future infrastructure for storm water management. One of the challenges related to this is the combined sewer system which is still operating in large areas of many cities worldwide. In Stockholm, combined sewer represents around 50% of the total sewer pipe length. In a Combined sewer system, once the conveyed discharge exceeds the system capacity, the system overflows, which can result in a diverse range of health and environmental problems. The cause of overflow has been strongly linked to runoff from intense rainfall events. Therefore, a key proposal to overcome this problem is to disconnect runoff from hard surfaces. This research aims to investigate the impact of applying a rainwater harvesting (RWH) and reuse system to collect runoff water from roof surfaces in areas with combined sewer system. A simulation water balance model for a rooftop RWH system was developed and two reuse purposes were considered, which entails toilet flushing and garden irrigation within the property. The study area consists of one building block within Kungsholmen area in Stockholm. The obtained results indicate that applying such systems can reduce runoff to the sewer system. Toilet flushing reuse shows a higher reduction impact on sewer flow than the use for irrigation. Toilet flushing reuse reduces annual runoff volumes to sewer in a range of 49.5% - 93.4% while irrigation provided reduction in a range of 11.6% - 26.3%. Regarding number of times that overflow from the combined sewer system occurs, toilet flushing reuse demonstrated reduction of 40% - 100% while 20% to 60% was reduced by irrigation reuse. For overflow volume, a reduction rate of 11% to 100% was reached through toilet flushing in contrast to 9% to 43% reduction from irrigation reuse. 19% to 37% of toilet flushing water demand was covered by the tank, while arange of 48% to 100% was covered for irrigation demand. All these parameters were found to be sensitive to change in tank size where increasing the size result in higher flow reduction rates. When considering implementing a reuse system, it is important to consider the applicability of RWH and reuse within the specific property. In areas that are under development, either of the two reuses can be considered depending on local conditions. However, in already built up area it is difficult to introduce a system that requires significant adjustment to existing pipe networks, such as reuse systems for toilet flushing. Systems for outdoor irrigation are possible to implement in most situations. When it comes to tank size, the optimal size will depend on the intended reuse, the catchment area and the objective of the system. For example, if the main objective is to reduce potable water consumption, a smaller tank can be used compared to where the main objective is to reduce sewer overflow. Hence, when considering implementing a rainwater reuse systems, each project will need to consider the local conditions as well as the individual objectives when determining the optimal reuse purpose and tank size. A cost-benefit analysis should also be considered when determining the optimal tank size for the intended use.