Abstract The concept of sustainable development in the dynamic operation concerns for the ecosystem¡¦s health, social justice and ideals of responsibility to future generations. From this point of view, the striking levels of economic growth achieved over the past few decades has been accompanied by environmental degradation, which exceeds the carrying capacity of supporting ecosystems in this island. Based on the characteristics of indicators on the Commission on Sustainable Development of United Nations, this research constructs quantitative approaches to evaluate whether the historical data in Taiwan meets the relationship in DSR (Driving-force-State-Response) indicator framework of sustainable development or not. This research also formulates the social-economic-environmental multi-objective programming system to the normative value of sustainable development for planning an optimal strategy path of sustainable development in Taiwan. Moreover, this research also forms a complex system called PREE system, which population (P), resources (R), environment (E) and economy (E) could develop with sustenance, order and coordination, to make policy planning for an overall, comprehensive and systematic mechanism of sustainable development. This research aims at building the indicator system of sustainable development in Taiwan, performing regression analysis for DSR system, finding key indicators of each individual dimension of sustainable development, developing the multi-objective integrated model solved by goal programming for sustainable development, and realizing the scenario analyses with assigned priority change of objective function. The results indicate the historical data in Taiwan meets the relationship in DSR indicator framework of sustainable development. The findings illustrate that the scenario for green income accompanied by the highest priority of environmental quality is optimal under the condition of moderate-driven rate of population growth, if green income per capita is considered to be the core set. On the other hand, the findings also indicate the declining rate of population growth, the depletion of water resource and energy, and the degradation of environment. Some suggestions related to public policies for spreading the international concept of sustainable development and for the balance of socio-environment and natural resource. This research explores that such a process generates as a means for nation to understand what specific actions to take in order to simulate the allocating results of national policy affecting the social, economic and environmental system and to measure progress towards sustainable development.