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published_or_final_version / Psychology / Master / Master of Philosophy

A method for simulating the transient responses of networks containing lossless transmission lines and lumped parameter elements of circuits, both linear and nonlinear, has been developed and investigated. The method combines the technique of network analysis and that of modal decomposition of transmission lines. A prototype computer simulation program, called UANTL, based on the developed algorithm has been implemented. Several example networks have been simulated using this program. The results have been compared with those generated by the well known circuit simulator program called SPICE. UANTL has shown several advantages over SPICE in simulating the transient responses of networks containing transmission lines. A description of the prototype version of UANTL and a summary of the results of numerical experiments are included.

New computer technologies are applied to the classical material engineering two-body abrasive wear process. The computer simulation provides an interactive and visual representation of the wear process. The influence of grit size, grit tip radius and load (at constant workpiece hardness and tool path) on the wear rate, wear coefficient and wear surface topography is predicted. The simulation implements microcutting and microploughing with material displacement to the sides of the groove. The validation of the simulation is demonstrated by comparing with the previous modelling literature and with experiments. / Thesis (M.Sc.)-University of Natal,Durban, 2002.

Leung Ka Man. / Thesis submitted in: August 2002. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 81-84). / Abstracts in English and Chinese. / Abstract --- p.ii / Acknowledgements --- p.iv / Contents --- p.v / List of Figures --- p.viii / List of Tables --- p.x / Chapter 1. --- Introduction --- p.1 / Chapter 1.1 --- Surgical Needle Simulation --- p.4 / Chapter 1.1.1 --- Data Source --- p.5 / Chapter 1.1.2 --- Computer-aided training simulation --- p.6 / Chapter 1.1.3 --- Existing Systems --- p.8 / Chapter 1.2 --- Research Goal --- p.10 / Chapter 1.3 --- Organization of this Thesis --- p.12 / Chapter 2. --- Haptization of Needle Interactions --- p.13 / Chapter 2.1 --- Data Collection --- p.13 / Chapter 2.1.1 --- Force Measurement --- p.14 / Chapter 2.1.2 --- Data Correlation --- p.17 / Chapter 2.1.3 --- Expert Opinion --- p.18 / Chapter 2.2 --- Haptic Display Devices --- p.18 / Chapter 2.2.1 --- General-purpose Devices --- p.19 / Chapter 2.2.2 --- Tailor-made Devices --- p.20 / Chapter 2.3 --- Haptic Models for Tissues --- p.21 / Chapter 2.3.1 --- Stiffness Models --- p.21 / Chapter 2.3.2 --- Friction Models --- p.22 / Chapter 2.3.3 --- Modelling of needle operations --- p.23 / Chapter 2.4 --- Chapter Summary --- p.24 / Chapter 3. --- Haptic Rendering of Bi-directional Needle Manipulation --- p.25 / Chapter 3.1 --- Data Source and Pre-processing --- p.26 / Chapter 3.1.1 --- Virtual Body Surface Construction --- p.28 / Chapter 3.1.2 --- Tissue Mapping for Haptic Rendering --- p.29 / Chapter 3.2 --- The PHANToM´ёØ Haptic Device --- p.31 / Chapter 3.3 --- Force Profile Analysis --- p.33 / Chapter 3.4 --- Haptic Model Construction --- p.37 / Chapter 3.4.1 --- Skin --- p.41 / Chapter 3.4.2 --- Adipose Tissue --- p.48 / Chapter 3.4.3 --- Muscle --- p.49 / Chapter 3.4.4 --- Bone --- p.50 / Chapter 3.5 --- Force Composition --- p.51 / Chapter 3.5.1 --- Structure Weight Compensation --- p.52 / Chapter 3.5.2 --- Path Constraint Force --- p.52 / Chapter 3.5.3 --- Needle Axial Force --- p.53 / Chapter 3.6 --- Interactive Calibration --- p.60 / Chapter 3.7 --- Skin Deformation --- p.61 / Chapter 3.8 --- Chapter Summary --- p.63 / Chapter 4. --- Parallel Visual-Haptic Rendering --- p.64 / Chapter 4.1 --- Parallel Network Architecture --- p.64 / Chapter 4.2 --- Visual Rendering Pipeline --- p.65 / Chapter 4.3 --- Haptic Rendering Pipeline --- p.67 / Chapter 4.4 --- Chapter Summary --- p.67 / Chapter 5. --- User Interface --- p.68 / Chapter 5.1 --- Needle Practice --- p.68 / Chapter 5.1.1 --- Moving Mode --- p.69 / Chapter 5.1.2 --- Acupuncture Atlas --- p.70 / Chapter 5.1.3 --- Training Results --- p.70 / Chapter 5.1.4 --- User Controls --- p.71 / Chapter 5.2 --- Device Calibration --- p.72 / Chapter 5.3 --- Model Settings --- p.72 / Chapter 5.4 --- Chapter Summary --- p.72 / Chapter 6. --- Conclusion --- p.73 / Chapter 6.1 --- Research Summary --- p.73 / Chapter 6.2 --- Suggested Improvement --- p.74 / Chapter 6.3 --- Future Research Works --- p.75 / Appendix A: Mapping Table for Tissues --- p.76 / Appendix B: Incremental Viscoelastic Model --- p.78 / Appendix C: Model Parameter Values --- p.80 / Bibliography --- p.81

Lam, Hiu Man. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 143-148). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts also in Chinese.

Dynamics Simulation Engine is the foundation of the whole system. The engine maintains a realistic dynamics scene in either automatic planning or haptic guided planning. It serves as an off-line verification of the planned motion so that the generated scheme can be 'played' with the engine. In this thesis, we developed a three-dimensional dynamics simulation engine based on an extension of the explicit time-stepping scheme and an application of the differential inclusion process introduced by J. J. Moreau. In the engine, we developed the contact propagation method for a general three-dimensional rigid-body system with multiple unilateral contacts without any bilateral constraints. / In our approach, a sequence of applied forces on the mass center of the workpiece is planned. The applied forces will push the workpiece to get in contact with all the locators. For this purpose, we developed a system with two engines, Motion Planning Engine and Dynamics Simulation Engine. / The goal of Motion Planning Engine is to make the workpiece in contact with all the six locators. Here, the workpiece is initially at an arbitrary place with not contact with any locator. The planning follows a simple scheme of monotonously increase the number of contacts with locators. Here we use a two-step scheme. First, finding the velocity of the workpiece that can approach the new locator while maintaining contacts with old locators. This can be formulated as a linear programming problem. Second, finding the applied force to realize such motion. This step is a central issue in the planning because for the rigid-body model, the solution to multiple frictional contacts is generally indeterministic. One possibility is jamming, that is, the applied force cannot move the workpiece even with less than six contacts. In this thesis, we will give criteria to determine whether the jamming will happen, and we will also derive an algorithm to generate the non-jamming applied force. / The thesis presents an approach to the fixture loading planning problem. That is, to plan the applied forces on the workpiece in order for it to be loaded into a manufacturing fixture. / Liu Tong. / "June 2005." / Adviser: Michael Yu Wang. / Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 4067. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (p. 115-124). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract in English and Chinese. / School code: 1307.

Shi Jingjing. / "August 2006." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2006. / Includes bibliographical references (p. 192-205). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese.

Yiu Yun Yip. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 86-87). / Yiu Yun Yip. / Contents --- p.i / List of Figures --- p.iii / List of Tables --- p.vi / Abstract --- p.vii / Acknowledgements --- p.viii / Chapter Chapter 1. --- Introduction --- p.1 / Chapter Chapter 2. --- The Fragmentation Model --- p.4 / Chapter 2.1 --- Interaction Potential --- p.5 / Chapter 2.2 --- Initial Configuration --- p.6 / Chapter 2.2.1 --- Enforcement of momentum conservation at time zero --- p.8 / Chapter 2.3 --- Time Evolution --- p.9 / Chapter 2.4 --- Summary --- p.10 / Chapter Chapter 3. --- Results for object with an initial circular shape --- p.11 / Chapter 3.1 --- Measurement of F(m) --- p.11 / Chapter 3.2 --- Results and Analysis --- p.14 / Chapter 3.3 --- Discussion --- p.24 / Chapter Chapter 4. --- Results for object with an initial square shape --- p.35 / Chapter 4.1 --- Results and Analysis --- p.35 / Chapter 4.2 --- Discussion --- p.43 / Chapter Chapter 5. --- Comparsion with experimental observations --- p.49 / Chapter 5.1 --- The Experiment --- p.49 / Chapter 5.2 --- Comparison --- p.50 / Chapter 5.2.1 --- Relation between the power-law exponent and the falling height --- p.50 / Chapter 5.2.2 --- Relation between the falling height and the total number of fragments --- p.50 / Chapter 5.2.3 --- Relation between the power-law exponent and the total num- ber of fragments --- p.53 / Chapter 5.3 --- Summary --- p.53 / Chapter Chapter 6. --- Maximum entropy formalism for fragment distributions --- p.55 / Chapter 6.1 --- The formalism --- p.55 / Chapter 6.2 --- Average potential and kinetic energies for fragments with mass m --- p.57 / Chapter 6.3 --- Comparison with simulation results --- p.67 / Chapter 6.3.1 --- Analysis for small R --- p.67 / Chapter 6.3.2 --- Analysis for large R --- p.69 / Chapter 6.4 --- Conclusion --- p.69 / Chapter Chapter 7. --- Conclusion --- p.75 / Appendix A. Main program --- p.76 / Appendix B. Derivation of P*(nm，m) and n*(m) --- p.84 / Bibliography --- p.86

Li, Hongjian. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (p. 132-156). / Abstracts in English and Chinese. / Abstract --- p.i / Abstract in Chinese --- p.iii / Acknowledgement --- p.iv / Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Motivation --- p.2 / Chapter 1.2 --- Objective --- p.2 / Chapter 1.3 --- Method --- p.3 / Chapter 1.4 --- Outline --- p.4 / Chapter 2 --- Background --- p.7 / Chapter 2.1 --- Overview of the Pharmaceutical Industry --- p.7 / Chapter 2.2 --- The Process of Modern Drug Discovery --- p.10 / Chapter 2.2.1 --- Development of an Innovative Idea --- p.10 / Chapter 2.2.2 --- Establishment of a Project Team --- p.11 / Chapter 2.2.3 --- Target Identification --- p.11 / Chapter 2.2.4 --- Hit Identification --- p.12 / Chapter 2.2.5 --- Lead Identification --- p.13 / Chapter 2.2.6 --- Lead Optimization --- p.14 / Chapter 2.2.7 --- Clinical Trials --- p.14 / Chapter 2.3 --- Drug Discovery via Computational Means --- p.15 / Chapter 2.3.1 --- Structure-Based Virtual Screening --- p.16 / Chapter 2.3.2 --- Computational Synthesis of Potent Ligands --- p.20 / Chapter 2.3.3 --- General-Purpose Computing on GPU --- p.23 / Chapter 3 --- Approximate Matching of DNA Patterns --- p.26 / Chapter 3.1 --- Problem Definition --- p.27 / Chapter 3.2 --- Motivation --- p.28 / Chapter 3.3 --- Background --- p.30 / Chapter 3.4 --- Method --- p.32 / Chapter 3.4.1 --- Binary Representation --- p.32 / Chapter 3.4.2 --- Agrep Algorithm --- p.32 / Chapter 3.4.3 --- CUDA Implementation --- p.34 / Chapter 3.5 --- Experiments and Results --- p.39 / Chapter 3.6 --- Discussion --- p.44 / Chapter 3.7 --- Availability --- p.45 / Chapter 3.8 --- Conclusion --- p.47 / Chapter 4 --- Structure-Based Virtual Screening --- p.50 / Chapter 4.1 --- Problem Definition --- p.51 / Chapter 4.2 --- Motivation --- p.52 / Chapter 4.3 --- Medicinal Background --- p.52 / Chapter 4.4 --- Computational Background --- p.59 / Chapter 4.4.1 --- Scoring Function --- p.59 / Chapter 4.4.2 --- Optimization Algorithm --- p.65 / Chapter 4.5 --- Method --- p.68 / Chapter 4.5.1 --- Scoring Function --- p.69 / Chapter 4.5.2 --- Inactive Torsions --- p.72 / Chapter 4.5.3 --- Optimization Algorithm --- p.73 / Chapter 4.5.4 --- C++ Implementation Tricks --- p.74 / Chapter 4.6 --- Data --- p.75 / Chapter 4.6.1 --- Proteins --- p.75 / Chapter 4.6.2 --- Ligands --- p.76 / Chapter 4.7 --- Experiments and Results --- p.77 / Chapter 4.7.1 --- Program Validation --- p.77 / Chapter 4.7.2 --- Virtual Screening --- p.81 / Chapter 4.8 --- Discussion --- p.89 / Chapter 4.9 --- Availability --- p.90 / Chapter 4.10 --- Conclusion --- p.91 / Chapter 5 --- Computational Synthesis of Ligands --- p.92 / Chapter 5.1 --- Problem Definition --- p.93 / Chapter 5.2 --- Motivation --- p.93 / Chapter 5.3 --- Background --- p.94 / Chapter 5.4 --- Method --- p.97 / Chapter 5.4.1 --- Selection --- p.99 / Chapter 5.4.2 --- Mutation --- p.102 / Chapter 5.4.3 --- Crossover --- p.102 / Chapter 5.4.4 --- Split --- p.103 / Chapter 5.4.5 --- Merging --- p.104 / Chapter 5.4.6 --- Drug Likeness Testing --- p.104 / Chapter 5.5 --- Data --- p.105 / Chapter 5.5.1 --- Proteins --- p.105 / Chapter 5.5.2 --- Initial Ligands --- p.107 / Chapter 5.5.3 --- Fragments --- p.107 / Chapter 5.6 --- Experiments and Results --- p.109 / Chapter 5.6.1 --- Binding Conformation --- p.112 / Chapter 5.6.2 --- Free Energy and Molecule Weight --- p.115 / Chapter 5.6.3 --- Execution Time --- p.116 / Chapter 5.6.4 --- Support for Phosphorus --- p.116 / Chapter 5.7 --- Discussion --- p.120 / Chapter 5.8 --- Availability --- p.123 / Chapter 5.9 --- Conclusion --- p.123 / Chapter 5.10 --- Personal Contribution --- p.124 / Chapter 6 --- Conclusion --- p.125 / Chapter 6.1 --- Conclusion --- p.125 / Chapter 6.2 --- Future Work --- p.128 / Chapter A --- Publications --- p.130 / Chapter A.1 --- Conference Papers --- p.130 / Chapter A.2 --- Journal Papers --- p.131 / Bibliography --- p.132