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1	Existují sekvenční determinanty funkční divergence GTPáz? / Are there any sequence determinants of functional divergence of GTPases? Kraus, Ondřej January 2013 (has links) Small GTPases are important proteins that affect many cellular processes. In my work I compare the five most important protein families of small GTPases - Arf, Rab, Ran, Ras and Rho to identify amino acids responsible for major functional differences between different protein families. To compare them, I have used the structural data from the PDB database and sequences from the UniProt database. I have discovered previously undescribed groups of amino acids specific for each protein family of small GTPases with the help of programs ConSurf and Sca5. I also carried out a pilot study of the applicability of B-factors as indicators of bond strength in the protein structure on the example of small GTPases. The first results are not entirely conclusive, but they do not exclude the applicability of B-factors as indicators of bond strength either. Powered by TCPDF (www.tcpdf.org)
2	Strukturně- a sekvenčně-závislá identifikace funkčně významných aminokyselin v proteinové rodině. / Structure- and sequence-based identification of functionally important amino acids in a protein family Peclinovská, Iveta January 2015 (has links) A group of small GTPases consist of over twenty protein families in the super class P-loop. It has a very diverse cell functions. Small GTPases regulate the formation of vesicular follicles, cytoskeleton and nuclear transport. They participate also on cell proliferation and signaling. The aim of my work is to find important amino acids that define family and distinguish each other. I focus on families Arf, Rab, Ran, Ras and Rho. At the Rho family I am also devoted to classes Rho, Rac and Cdc42. Amino acids are identified using bioinformatic programs selected Consurf and Sca5. The objective is also to test P2RANK specialized tool developed at the Charles University in Prague that predict ligand binding sites from protein structure in different families. Founding amino acids can have a big role in the functional divergence of individual families and classes of small GTPases and can be the basis for future study example for the proliferation of cancerous cells. 1.1 Keywords Powered by TCPDF (www.tcpdf.org)
3	Understanding the Pathogenic Nature of L359V Variant of GATA-2 with Respect to Chronic Myeloid Leukemia. Nadwodney, Martin Aleksander January 2022 (has links) No description available. Bioinformatics Biochemistry Computer Science Oncology Bioinformatics Cell Differentiation Cell Proliferation Chronic Myeloid Leukemia CML ClinVar ConSurf GATA-2 GATA-2 Variant GATA-2 Variants I-TASSER L359V L359V variant RaptorX STRING Xavier Protocol Xavier Protocol Pie Chart YASARA Zinc Finger 2 ZF-2

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