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Bioinformatický nástroj pro predikci struktury proteinů / Bioinformatics Tool for Protein Structure PredictionPlaga, Michal January 2016 (has links)
The goal of this thesis is test and comparation of the offline tools for prediction of protein structure and creation of metaprediktor, which allows the user to select the appropriate tool, according to given parameters. Testing tool is based on a dataset of proteins, which is based on the SCOP database and it is trying to be as balanced as possible to include proteins from different families and thus could best evaluate individual tools. The results of this thesis are requirements of metaprediktor and also which data and settings can be allowed and processed and how it will be implemented.
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Webový server pro predikci 3D struktury proteinu / Web Server for Protein Structure PredictionVotroubek, Lukáš January 2013 (has links)
This work deals with proteins, especially with their structure and kinds of tertiary, or 3D, structure prediction. Tertiary structure prediction is very important for function prediction of this vitally important substance. Bioinformatics do this prediction much more effective and faster, because classical methods of structure prediction directly from molecule are very expensive and slow. On the other hand they are much more exact. Objective of this thesis is to describe tertiary structure prediction methods, describe used tools and possibility of automatic communication with them. Next objective is describe implementation of server, that will serve to protein engineers for more effective finding of information about tertiary structure from more servers without requesting each of them separately. Results of testing will be described in this work too.
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Understanding the Pathogenic Nature of L359V Variant of GATA-2 with Respect to Chronic Myeloid Leukemia.Nadwodney, Martin Aleksander January 2022 (has links)
No description available.
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