Coronary artery bypass grafting (CABG) is the most common cardiac surgical operation performed in western countries, and is also increasingly being performed in developing countries. However the long-term results of CABG using the saphenous vein graft have not been satisfactory. Surgeons have therefore been seeking a better conduit. The radial artery (RA) is a potentially suitable alternative conduit and has to date provided good early results. This thesis investigates the utility of the RA as a coronary artery bypass graft from a number of perspectives. It demonstrates the safety of RA harvesting by examining hand collateral circulation using anatomical dissection, physical examination using the modified Allen test, measuring digital blood pressure, and examining the flow velocity in the digital artery using Doppler ultrasound. Anatomical examinations revealed consistent continuity between the RA and ulnar artery in the hand through either superficial or deep palmar arches. The modified Allen test was found to be useful as a screening test compared with the Doppler dynamic test and digital blood pressure index. A histological comparison was made between pre-existing intimal disease in the RA compared with that in the standard conduit the internal thoracic artery (ITA). The RA showed a higher prevalence and degree of intimal disease than ITA. Risk factors for intimal hyperplasia in the RA were age, diabetes, smoking and peripheral vascular disease. The only predictor for medial calcification was age. (For complete abstract open document)

Diss.--Tübingen--Eberhard-Karls-Univ., 2007. / Sources et bibliogr. p. 443-475.

Reproduction de : Thèse de doctorat : Musicologie : Poitiers : 2008. / Titre provenant de l'écran titre. Bibliogr. f. 427-446. Notes bibliogr. Index.

Tissue engineering, with the ultimate goal of engineering artificial tissues or organs to replace malfunctioning or diseased ones inside the human body, provides a substitute for organ transplantation. Driven by the growing, tremendous gap between the demand for and the supply of donated organs, tissue engineering has been advancing rapidly. There has been great success in engineering artificial organs such as skin, bone, cartilage and bladders because they have simple geometry, low cell oxygen consumption rates and little requirements for blood vessels. However, difficulties have been experienced with engineering thick, complex tissues or organs, such as hearts, livers or kidneys, primarily due to the lack of an efficient media exchange system for delivering nutrients and oxygen and removing waste. Very few types of cells can tolerate being more than 200 μm away from a blood vessel because of the limited oxygen diffusion rate. Without a vasculature system, three-dimensional (3D) engineered thick tissues or organs cannot get sufficient nutrients, gas exchange or waste removal, so nonhomogeneous cell distribution and limited cell activities result. Systems must be developed to transport nutrients, growth factors and oxygen to cells while extracting metabolic waste products such as lactic acid, carbon dioxide and hydrogen ions so the cells can grow, proliferate and make extracellular matrix (ECM), forming large-scale tissues and organs. However, available biomanufacturing technologies encounter difficulties in manufacturing and integrating vasculature networks into engineered constructs. This work proposed a novel 3D bioprinting technology that offers great potential for integration into thick tissue engineering. The presented system offered several advantages, including that it was perfusable, it could print conduits with smooth, uniform and well-defined walls and good biocompatibility, it had no post-fabrication procedure, and it enabled direct bioprinting of complex media exchange networks.

archives@tulane.edu / In response to extant literature on college students’ sense of belonging that analyzes the concept as a relatively siloed phenomenon, this study offers a mixed methods exploratory analysis of college students’ sense of belonging that examines multiple domains of college life simultaneously. Quantitative results reveal that students fall within three classes of sense of belonging – Low, Medium, High – and that sense of belonging to a campus organization is least impactful on the classes whereas sense of belonging to a friend group is most impactful. Key factors impact a students’ probability of being in a particular class of sense of belonging: Students from racial and ethnic minority backgrounds as well as non-Honors students are most likely to experience a low sense of belonging, and students from relatively high socioeconomic statuses are least likely to experience a low sense of belonging. Qualitative results analyze students’ definitions of sense of belonging and unpack aspects of the quantitative results. First, students’ definitions reveal four categories of sense of belonging: Self-Centrics, Co-Creators, Seekers, and Conformists. Second, campus organizations offer a framework by which students meet friends, and the importance of this structure goes largely unnoticed by students. On the contrary, students highlight the importance of sense of belonging to a friend group as instrumental to developing sense of belonging in other domains. Third, the theme of exclusion operates as a foil to the similarity that informs interviewees’ sense of belonging. Exclusion refers to perceptions that one is an insider or outsider, and a key component of exclusion is the degree to which students have agency in their experiences of exclusion. Fourth, Gateways of Belonging and Conduits of Belonging offer a means by which students strengthen sense of belonging in various domains. Gateways of Belonging refer to frameworks that bring together students around shared experience or purpose. Conduits of Belonging refer to specific roles that people fill in such a way that they model what sense of belonging can look like in a specific domain. Keywords: College students’ sense of belonging; mixed methods; latent class analysis; semi-structured interviews; Gateways of Belonging; Conduits of Belonging / 1 / Robert Alexander Ellison

This is a high fantasy novel about Iníon Ríúil, a girl who discovers she has the ability to manipulate magic. Two weeks before Iní­'s seventeenth birthday, thieves attack their home and her grandmother is murdered. After her grandmother's death, Iní­ goes in search of the father she has never met and ends up joining the Magical Alliance, where she learns more about her unique skills. Iní­ is a full conduit, someone who possesses all four of the possible conduit abilities: shielding, absorption, transformation, and amplification. Because someone has been kidnapping other conduits, the Magical Alliance assigns guardians for her protection: a goblin, an elf, and another being whose exact race is unknown. Iní­ and her guardians are assigned to find out more about the bloodstone, an ancient relic made to function the same as conduits, something the Races thought long destroyed. They suspect the dragons to be looking for the bloodstone and worry its discovery could start a war. The culminating challenges in the novel involve Iní­ finding the bloodstone and learning the identity of her father.

Drying and evaporation from nanoscale conduits are two ubiquitous phenomena found in nature. As these two nanoscale liquid-vapor phase change phenomena are significantly “accelerated” compared with the corresponding ones at micro- and macro-scales, various industrial applications, including oil recovery, electronic cooling, membrane desalination, and energy harvesting, have been developed. Despite their important implications, the fundamental mechanisms for these two accelerated phase-change processes have not been completely understood. For drying, it is widely accepted that liquid corner flow and film flow could significantly enhance mass transport in microscale conduits other than the sole contribution by vapor diffusion. However, it is unclear if the same principles apply to smaller scales and if the vapor diffusivity will change at the nanoscale. For evaporation, the evaporation kinetics at the nanoscale interface, rather than liquid/vapor transport toward/from the interface, determine the ultimate transport limit, which can be significantly higher than the classical prediction derived under quasi-equilibrium evaporation conditions. Still, the contributions to such enhanced kinetically limited evaporation remain unclear. This thesis aims to answer these unsolved questions by conducting systematic experimental studies on drying and evaporation from single nanochannels and nanopores. We used state-of-art fabrication to create close-end 2D nanochannels with heights from 29 to 122 nm and measure water drying in such channels using an optical microscope. Combining with the channel confinement study and relative humidity study, we decoupled the individual contributions from vapor and liquid transport to the drying and extracted the water vapor diffusivity in nanochannels. We also developed a hybrid nanochannel-nanopore design to achieve and measure kinetically limited evaporation flux from silicon nitride nanopores and graphene nanopores with pore diameters ranging from 24 to 347 nm. Our results show that the evaporation flux increases with the decreasing diameter for both types of nanopores. Furthermore, graphene nanopores overall exhibit higher evaporation fluxes than silicon nitride nanopores with similar diameters. We attribute the diameter-dependent evaporation flux to the diameter-dependent hydronium ion concentration in silicon nitride nanopores and the edge-facilitated evaporation in graphene nanopores, respectively. We expect this work to advance our understanding of nanoscale fast drying and evaporation and provide design guidance for novel nanoporous membrane evaporators.

Cette étude porte sur l'influence de la forme des particules sur le comportementmécanique des matériaux granulaires, et les mécanismes de transfert de charge quis'y développent, notamment dans les cas des conduits enterrés. La géométrie desparticules (polygones de forme convexe ou assemblage de particules de forme concaveconstitués de plusieurs disques superposés et indissociables) a été caractérisée par uncoefficient de forme α. Cette étude est basée sur une approche numérique par élémentsdiscrets. Des simulations numériques de l'essai de compression biaxiale montrent queles caractéristiques macroscopiques ou géométriques de l'échantillon granulaire, telque l'angle de frottement macroscopique, la compacité, ou la nature des bandes decisaillement, dépendent fortement du coefficient de forme α et de la convexité ou nonconvexité des grains.Les mécanismes de transfert de charge au dessus d'un conduit souple ont été étudiésexpérimentalement (rouleaux bidimensionnels en condition de déformation plane) etnumériquement (MED). Les expérimentations réalisées montrent que la présence duconduit à peu d'in_uence sur le comportement macroscopique de l'assemblée granulairelors d'une sollicitation biaxiale. Les résultats du modèle numèrique convergentavec les rèsultats expérimentaux et mettent en évidence la présence des mécanismes detransfert de charge au dessus du conduit dont les intensités dépendent du coefficientde forme α. / This study was devoted to the in_uence of grain shape on the mechanical behaviourof granular materials and its e_ect on load transfer over underground pipes. Shapeof convex polygons and concave clumps of discs was generalised with a geometricalparameter α. In the study a Discrete Element Modeling (DEM) approach was used.Biaxial compression of granular assemblies revealed that mechanical and geometricalproperties like porosity, macroscopic friction or shear localisation depends both on αand on grain (non-)convexity.The intergranular load transfer over a _exible pipe was studied both experimentally(2D rods in a plain strain apparatus) and numerically (DEM). The experimentsshowed that the pipe has no signi_cant impact on the macroscopic behaviour of theassembly. The numerical model complied with the experiments and revealed that thearching e_ect in a sheared granular medium exists above the pipe and is magni_edwith the increase of α of the grains.

For the protection of wetland and water resources it would be beneficial to understand when collapse conduits function as recharge points to the underlying aquifer. Inexpensive, noninvasive methods to detect recharge are desirable. Previous studies show negative self-potential (SP) anomalies over sinkholes that correspond to the expected electrokinetic effects of groundwater flowing downward through a conduit. SP surveys are less labor-intensive than high-resolution 3D GPR and resistivity, and continuous long-term monitoring is possible. However, before SP surveys can be reliable indicators of flow, SP contributions from ET, conductivity changes, redox reactions, thermoelectric effects, cultural noise, and lateral flow must be understood. A year of continuous SP monitoring was combined with high-resolution 3-D GPR surveys, and intermittent water table monitoring over two small covered-karst sinkholes in Tampa, Florida. Positive and negative SP anomalies episodically manifested over conduits, suggesting that conduit flow is dynamic, not static. Three distinct SP flow regimes in the conduits are postulated: fast flow open to the aquifer, slow flow open to the confining layer through the collapse conduit walls, and a conduit, plugged high enough to behave like the rest of the confining layer. SP responses after rain events also appear to measure the effects of two moving Gaussian wetting front curves, one striking the monitoring electrode, one the reference. viii The wetting front volumes are differently dispersed by traveling different distances. By comparing curve shapes for all possible pairs of electrodes, it may be possible to establish surficial infiltration and flow patterns. Temporal SP response clearly shows SP is also affected by soil conductivity, rainfall history, and cultural noise. Ultimately, SP changes too frequently to rely on measurements many hours or days apart. Over the course of the year, the electrodes became less responsive to rainfall and more erratic. Extremely wet and dry conditions seemed to affect responses. The porous faces of the electrodes or the bentonite clay gel used to enhance contact may decline. It appears a better design for electrodes and electrode contact needs to be developed. To test the intermittent behavior hypothesis, more conduits need to be studied, and moisture and SP must be studied concurrently. Several reference electrodes placed in various topographic, vegetative, geologic, and climatic settings could help distinguish groundwater flow from other SP sources. SP is a valuable research tool; however external complexities such as cultural noise, sinkhole lithology, and the state of the unsaturated zone make SP data difficult to interpret without ancillary information.

No / In recent years, for neurodegenerative diseases therapy, research has focused on the stem cells therapy. Due to promising findings in stem cell therapy, there are various sources of stem cells for transplantation in human. The aim of this study was to evaluate sciatic nerve regeneration in the rat after nerve transaction followed by human endometrial stem cells (hEnSCs) treatment into poly (e-caprolactone)/collagen/nanobioglass (PCL/collagen/NBG) nanofibrous conduits. After treatment of animals, the performance in motor and sensory tests, showed significant improvement in rats treated with hEnSCs as an autograft. H&E images provided from cross-sectional and, longitudinal-sections of the harvested regenerative nerve as well as immunohistochemistry results indicated that regenerative nerve fibres had been formed and accompanied with new blood vessels in the conduit cell group. Due to the advantage of high surface area for cell attachment, it is reported that this electrospun nerve conduit could find more application in cell therapy for nerve regeneration in future, to further improve the functional regeneration outcome, especially for longer nerve defect restoration. In conclusion, our results suggest that the PCL/collagen/NBG nanofibrous conduit filled with hEnSCs is a suitable strategy to improve nerve regeneration after a nerve transaction in rat. / Iran National Science Foundation (INSF) grant number 95849510