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This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was obtained by increasing the ratio of the water insoluble polymer in the coat and increasing the percent weight gain of the coating. Simulated plasma concentration versus time profiles after administration of 30 mg dose of selected formulations showed a prolonged nifedipine release with concentrations above the minimum effective concentration for up to 12 hours. Bioavailability and bioequivalence of tableted test formulation of verapamil HCL was determined in 8 volunteers and compared to Covera HS® under fed and fasting conditions. The 90% confidence intervals for individual percent ratios of the Cmax, AUC₀₋₅₈ and AUC₀ were not within the range of 80 - 125% in both fed fasted states, suggesting that these formulations are not bioequivalent. the bioavailability of verapamil from the new formulation was higher state but this effect was not statistically significant. Pharmacokinetics of terbinafine administered orally at single doses of 15, 30, 60 and 120 mg were determined in raptors to recommend an appropriate dosing scheduled for terbinafine in the treatment of Aspergillosis. Calculation of steady state trough terbinafine plasma concentration after administration of daily doses of 15 or 30 mg/day showed that 30 mg daily dose of terbinafine administered orally in raptors produces a steady state trough terbinafine plasma concentration above the minimum inhibitory concentration (MIC) of(0.8 1.6) µg/ml against aspregillus fumigatus. From the data, 30 mg per day oral dose of terbinafine should be the recommended dose for treatment of aspergillosis in raptors. Approximate pharmacokinetic linearity of terbinafine was demonstrated for AUC[subscript 0-t] in the dose range of 15 120 mg while non-linearity for Cmax in the same dose range was demonstrated using the power model. / Graduation date: 2005

published_or_final_version / Dentistry / Master / Master of Dental Surgery

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The dt-αn continuum in the presence of the muon is studied in detail, and it is shown that the existence of extended continuum states just beneath the d+(tμ)₁(s) threshold can lead to a variety of 'pseudoresonant' fusion processes with a temperature and density dependence distinct from those leading to molecular formation. Various in-flight and pseudoresonant fusion reaction cross sections involving the excitation of electromolecular states and two or three scattering bodies are computed. Fusion processes in very dense plasmas of ∼10³ liquid hydrogen density are studied, and it is shown that in this environment both sticking and muon transfer problems are eliminated, and that pseudoresonant fusion processes should dominate. In this context, the use of negatively charged hadrons as potential catalytic particles is also considered.

In problems involving highly forward-peaked scattering, the Boltzmann transport equation can be simplified using the Fokker-Planck model. The purpose of this project was to develop an analytical solution to the resulting Fokker-Planck equation. This analytical solution can then be used to benchmark numerical transport codes. A numerical solution to the Fokker-Planck equation was also developed. The analytical solution found is a generalized function. It satisfies the purpose of the project with two limitations. The first limitation is that the solution can only be evaluated for certain sources. The second limitation is that the solution can only be evaluated for small times. The moments of the Fokker-Planck equation can be evaluated for any time. The numerical solution developed works for all sources and all times. The analytical solution, then, provides an accurate and precise benchmark under certain conditions. The numerical solution provides a less accurate benchmark under all conditions.

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