"'The future is ripe for change. Our times demand educational advance and reconstruction of a high order. But now, as always, the fundamental directions in which we seek to move toward that goal will assuredly determine the measure of our success in achieving it. How then shall we envision an education that is adequate to meet the imperative need of the epoch?' Robert D. Dolley, one of the leaders in the field of Vocational Education in the United States today, has already discovered the partial solution to the above question. It was through his keen vision and understanding of the problems that are confronting the schools today that he worked out the plan of operation for the Diversified Cooperative Training program some ten years ago. This program, although young in years, has spread through the United States and has proved its effectiveness and practicality everywhere it has been established. It can be said with some measure of assurance that this DCT program will be adopted by most of the schools of the nation as one method of meeting the needs of the students and of bridging the gap between the schools and the community"--Introduction. / Typescript. / "Submitted in partial fulfillment of the requirements for the Master's Degree." / Advisor: Margaret C. Bristol, Professor directing paper. / Includes bibliographical references (leaves 47-48).

Thesis advisor: Masayuki Wasa / When a catalytic reaction is carried out between two reactants, usually only onereactant is activated by a single catalyst while the other component is pre-activated so that the sluggish reactivity was compensated. In order to broaden the substrate scope, the development of cooperative catalysts that can generate both electrophilic and nucleophilic species in situ represents a compelling research objective. This thesis is focused on the development of cooperative catalyst systems and their applications to α- and β-amino C−H bond functionalization. In the first chapter of this thesis, a brief summary of the present cooperative catalysts will be discussed. In the second chapter, the development of cooperative acid/acid catalysts for the α-alkynylation of N-alkylamines will be discussed. Typically, catalytic α-amino C−H alkynylation process is carried out under oxidative conditions, and enantioselective reactions are confined to tetrahydroisoquinoline derivatives. We disclose a strategy for the union of N-alkylamines and trimethylsilyl alkynes through cooperative actions of two Lewis acids, B(C 6 F 5 ) 3 and a Cu-based complex without the use of oxidants. We proposed that various propargylamines can be synthesized through the reaction between a L n Cu−alkynyl complex and an iminium ion that are generated in situ. Furthermore, the utility of this protocol was demonstrated by applications in late stage α-alkynylation of bioactive amines and stereoselective synthesis of propargylamines. In the third chapter of this thesis, catalytic and regioselective deuteration of β-amino C−H bonds in an array of N-alkylamine-based pharmaceutical compounds will be described. Isotopic labeling of β-amino C−H bond is promoted by the cooperative action of Lewis acidic B(C 6 F 5 ) 3 and Brønsted basic N-alkylamine, converting a bioactive amine first into an iminium ion and then the corresponding enamine. Meanwhile, the acid/base catalysts can also promote the dedeuteration of acetone-d 6 to afford a deuterated ammonium ion and a boron enolate. Ensuing deuteration of the enamine by deuterated ammonium ion followed by borohydride reduction leads to the formation of β-deuterated bioactive amines with up to 99% deuterium incorporation. / Thesis (MS) — Boston College, 2020. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.

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Digitized by Kansas Correctional Industries

Call number: LD2668 .T4 1958 T38

LD2668 .T4 1962 K78

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1981. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH. / Includes bibliographical references. / by George Smith Jr. / M.C.P.

Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references. Also available on the Internet. Also issued online.