This study indicate that the chemical inter-diffusion between the Cr-doped glass/glass ceramic and quartz (SiO2) influence the fluorescence properties of glass, mainly because of Cr4+ replacing by tetrahedral of Si4+. Cr4+ fluorescence intensity was reduced and its emission band was shifted to longer wavelength (red shift). We selected the SiO2-based glass composition: Mg2SiO4 glass-ceramic and reduced a ratio of SiO2 sintered into the ceramic powder. This paper used diffusion characteristics of quartz (SiO2) to compensate for reduced SiO2 in the ceramic powder. After diffusing with quartz (SiO2), ceramics powder changed into glasses. The intensity of fluorescence and the crystal field had been improved. The center of Cr4+ fluorescence is about 1100nm belonging to Cr4+:Mg2SiO4 crystal. The ratio of Cr4+ in Mg2SiO4 crystal/Cr4+ in MgO-SiO2 glass increases from 0.33 to 1.74. The goal is to develop a novel glass which is resistant to SiO2 inter-diffusion degradation during fiber fabrication, and provide the new fiber technology to avoid the influence of inter-diffusion This study provides new types of treatment: Laser induced crystallization. Laser heat-treatment can more quickly induce crystals in glass during seconds, than traditional heat-treatment which require several hours. This study also indicate that one step laser heat-treatment induce micro-crystals, but one step laser heat-treatment induce nano-crystals. We successfully produced nano-crystallization during seconds.