Validity generalization work over the past 25 years has called into question the veracity of the assumption that validity is situationally specific. Recent theoretical and methodological work has suggested that validity coefficients may be transportable even if true validity is not a constant. Most transportability work is based on the assumption that the distribution of rho ( ρi ) is normal, yet, no empirical evidence exists to support this assumption. The present study used a competing model approach in which a new procedure for assessing transportability was compared with two more commonly used methods. Empirical Bayes estimation (Brannick, 2001; Brannick & Hall, 2003) was evaluated alongside both the Schmidt-Hunter multiplicative model (Hunter & Schmidt, 1990) and a corrected Hedges-Vevea (see Hall & Brannick, 2002; Hedges & Vevea, 1998) model. The purpose of the present study was two-fold. The first part of the study compared the accuracy of estimates of the mean, standard deviation, and the lower bound of 90 and 99 percent credibility intervals computed from the three different methods across 32 simulated conditions. The mean, variance, and shape of the distribution varied across the simulated conditions. The second part of the study involved comparing results of analyses of the three methods based on previously published validity coefficients. The second part of the study was used to show whether choice of method for determining whether transportability is warranted matters in practice. Results of the simulation analyses suggest that the Schmidt-Hunter method is superior to the other methods even when the distribution of true validity parameters violates the assumption of normality. Results of analyses conducted on real data show trends consistent with those evident in the analyses of the simulated data. Conclusions regarding transportability, however, did not change as a function of method used for any of the real data sets. Limitations of the present study as well as recommendations for practice and future research are provided.

Includes vita. / Title from PDF of title page. / Document formatted into pages; contains 134 pages. / Thesis (Ph.D.)--University of South Florida, 2003. / Includes bibliographical references. / Text (Electronic thesis) in PDF format. / ABSTRACT: Validity generalization work over the past 25 years has called into question the veracity of the assumption that validity is situationally specific. Recent theoretical and methodological work has suggested that validity coefficients may be transportable even if true validity is not a constant. Most transportability work is based on the assumption that the distribution of rho ( ) is normal, yet, no empirical evidence exists to support this assumption. The present study used a competing model approach in which a new procedure for assessing transportability was compared with two more commonly used methods. Empirical Bayes estimation (Brannick, 2001; Brannick & Hall, 2003) was evaluated alongside both the Schmidt-Hunter multiplicative model (Hunter & Schmidt, 1990) and a corrected Hedges-Vevea (see Hall & Brannick, 2002; Hedges & Vevea, 1998) model. The purpose of the present study was two-fold. The first part of the study compared the accuracy of estimates of the mean, standard deviation, and the lower bound of 90 and 99 percent credibility intervals computed from the three different methods across 32 simulated conditions. The mean, variance, and shape of the distribution varied across the simulated conditions. The second part of the study involved comparing results of analyses of the three methods based on previously published validity coefficients. The second part of the study was used to show whether choice of method for determining whether transportability is warranted matters in practice. Results of the simulation analyses suggest that the Schmidt-Hunter method is superior to the other methods even when the distribution of true validity parameters violates the assumption of normality. Results of analyses conducted on real data show trends consistent with those evident in the analyses of the simulated data. Conclusions regarding transportability, however, did not change as a function of method used for any of the real data sets. Limitations of the present study as well as recommendations for practice and future research are provided. / System requirements: World Wide Web browser and PDF reader. / Mode of access: World Wide Web.

Nous proposons de modéliser les données issues des technologies de séquençage du transcriptome (RNA-Seq) à l'aide de la loi binomiale négative, et nous construisons des modèles de segmentation adaptés à leur étude à différentes échelles biologiques, dans le contexte où ces technologies sont devenues un outil précieux pour l'annotation de génome, l'analyse de l'expression des gènes, et la détection de nouveaux transcrits. Nous développons un algorithme de segmentation rapide pour analyser des séries à l'échelle du chromosome, et nous proposons deux méthodes pour l'estimation du nombre de segments, directement lié au nombre de gènes exprimés dans la cellule, qu'ils soient précédemment annotés ou détectés à cette même occasion. L'objectif d'annotation précise des gènes, et plus particulièrement de comparaison des sites de début et fin de transcription entre individus, nous amène naturellement à nous intéresser à la comparaison des localisations de ruptures dans des séries indépendantes. Nous construisons ainsi dans un cadre de segmentation bayésienne des outils de réponse à nos questions pour lesquels nous sommes capable de fournir des mesures d'incertitude. Nous illustrons nos modèles, tous implémentés dans des packages R, sur des données RNA-Seq provenant d'expériences sur la levure, et montrons par exemple que les frontières des introns sont conservées entre conditions tandis que les débuts et fin de transcriptions sont soumis à l'épissage différentiel. / We propose to model the output of transcriptome sequencing technologies (RNA-Seq) using the negative binomial distribution, as well as build segmentation models suited to their study at different biological scales, in the context of these technologies becoming a valuable tool for genome annotation, gene expression analysis, and new-transcript discovery. We develop a fast segmentation algorithm to analyze whole chromosomes series, and we propose two methods for estimating the number of segments, a key feature related to the number of genes expressed in the cell, should they be identified from previous experiments or discovered at this occasion. Research on precise gene annotation, and in particular comparison of transcription boundaries for individuals, naturally leads us to the statistical comparison of change-points in independent series. To address our questions, we build tools, in a Bayesian segmentation framework, for which we are able to provide uncertainty measures. We illustrate our models, all implemented in R packages, on an RNA-Seq dataset from a study on yeast, and show for instance that the intron boundaries are conserved across conditions while the beginning and end of transcripts are subject to differential splicing.