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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Glycoside Hydrolases, Family GH73 and a Structural Characterization of GH73 Enzyme FlgJ

Zaloba, Patryk 14 January 2016 (has links)
FlgJ belongs to Carbohydrate Active enZyme (CAZy) family GH73 and facilitates passage of the bacterial flagellum through the peptidoglycan (PG) layer by cleaving the glycosidic bonds within glycan strands of PG. In this thesis I present the structure of the GH73 enzyme FlgJ from bacterial pathogenSalmonella typhimurium (St FlgJ). The St FlgJ active site was found to be blocked by the C-terminus of a neighbouring symmetry mate. To investigate if the C-terminus of FlgJ inhibits enzymatic activity similarly to the N-terminus of GH73 enzyme Auto, the glycolytic activity of St FlgJ was measured with and without its C-terminus. The assays revealed St FlgJ activity to be unaffected by the presence of the C-terminal sequence. Removal of the C-terminus did, however, allow a crystal structure of the domain to be obtained where a β-hairpin known to accommodate critical catalytic residues was found capable of opening widely, which likely aids in substrate capture and turnover. / February 2016

High pressure structural investigations of solids using X-ray and synchrotron radiation

Heath, Andrew Edmund January 1989 (has links)
X-ray diffraction has been used to investigate the structure and structural behaviour of several inorganic solids under variable pressure and temperature conditions. A brief description of the diamond anvil cell (d.a.c.) and its applications to the high- pressure investigations is given. A spectroscopic system built for pressure calibration is discussed, plus an account of powder diffraction data analysis including a detailed description of a software package engineered for the specific reduction of powder data obtained under variable pressure. Potassium nitrate (KNO3) has seven polymorphs in the pressure range 0.0-4.0 GPa. This material has been studied with energy dispersive powder diffraction (EDXRD) to 9.3 GPa. The structure of the non-ambient phase IV refined by neutron diffraction at 0.36 GPa has been confirmed, the compressibility of the high-pressure phase measured and found to be anisotropic with axial compression ratios a:b:c = 1.0:0.64:0.50. The valence induced structural transition at 0.8 GPa in EuPd2Si2 has been studied using EDXRD and uni-axial compressibilities calculated. A basic explanation of the electronic theory which accompanies the subtle shortening of the a lattice parameter in the tetragonal asymmetric unit is also given. The structures of two compounds CH3HgX (X = I, Cl) have been investigated using single crystal and angle-dispersive powder techniques respectively. The crystal structure of methyl mercuric iodide is reported. CH3HgCl has been observed above and below the temperature induced I/II phase boundary at 162.5 K. A hypothesis detailing the iso-structural nature of CH3HgCl low temperature phase II and the ambient phase I of the analogous methyl mercuric bromide is also tested.

Experimental investigation of layered crystals using Raman spectroscopy and ultrasonic methods

Sehery, A. A. January 1988 (has links)
No description available.

Structural deformations in phosphorus and nitrogen complexes

Dunne, Barry John January 1989 (has links)
No description available.

A structural study of some unusual inorganic charge transfer salts

Stringer, A. M. January 1988 (has links)
No description available.

Crystallographic studies of intermediate states of haemoglobin

Luisi, B. F. January 1986 (has links)
No description available.

Investigations of Sayre's equation

Shiono, Masaaki January 1989 (has links)
No description available.

Studies of coloured space patterns

Afsharnaderi, M. January 1986 (has links)
No description available.

Molecular structure by diffraction methods

Forsyth, G. A. January 1988 (has links)
No description available.

Applications of synchrotron radiation Laue diffraction in molecular structure studies

Maginn, Stephen James January 1989 (has links)
No description available.

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