The production of higher alcohols from synthesis gas over Cu-Co-Cr-K catalysts has been studied. The production rate of alcohol was measured in the flow reactor, operating at 250 to 350°C, 3500 to 8000 gas hourly space velocity, and 900 to 1800 psig. The productivity as a function of temperature, pressure, gas hourly space velocity, carbon dioxide content of the feed, and reaction time was also examined. Physisorption data have been analyzed using the Langmuir model, the Brunauer-Emmett-Teller (BET) method, the Barret-Joyner-Halenda (BJH) method, and the de Boer and Halsey t-method. The surface areas of catalysts CB1(1), CB1(3), and CB1(1) after reaction were 39.9 ± .9 m2/g, 28.9 ± 1.7 m2/g, and 26.5 ± 0.3 m2/g, respectively. Moreover, information such as pore size distribution, pore shape, monolayer volume, micropore volume and thickness of adsorption layer were also obtained. The atomic concentration and oxidation states of near surface species were established by X-ray Photoelectron Spectroscopy.