Encoding and consolidation of memories are two processes within the hippocampus, and connected cortical networks, that recruit different circuit level dynamics to effectively process and pass information from brain region to brain region. In the hippocampal CA1 pyramidal layer local field potential (LFP), these processes take the form of theta and sharp wave ripples (SPW-Rs) for encoding and consolidation, respectively. As an animal runs through an environment, neurons become active at specific locations in the environment (place cells) increasing their firing rate, functionally representing these specific locations. These firing rate increases are organized within the local theta oscillations and sequential activation of many place cells creates a map of the environment. Once the animal stops moving and begins consummatory behaviors, such as eating, drinking, or grooming, theta activity diminishes, and large irregular activity (LIA) begins to dominate the LFP. Spontaneously, with the LIA, the place cells active during the experience are replayed during SPW-Rs in the same spatial order they were encountered in the environment. Both theta and SPW-R oscillations and their associated neuronal firing are necessary for effective place recognition as well as learning and memory. As such, interruption or termination of SPW-R events results in decreased learning performance over days. During exploration, the associated theta and sequential place cell activity is thought to encode the experience. During quiet restfulness or slow wave sleep (SWS), SPW-R events, that replay experience specific place sequences, are thought to be the signal by which systems consolidation progresses and the hippocampus guides cortical synaptic reorganization. The granular retrosplenial cortex (gRSC) is an associational area that exhibits high frequency oscillations (HFOs) during both hippocampal theta and SPW-Rs, and is potentially a period when the gRSC interprets incoming content from the hippocampus during encoding and systems consolidation. However, the precise laminar organization of synaptic currents supporting HFOs, whether the local gRSC circuitry can support HFOs without patterned input, and the precise coupling of hippocmapla oscillations to gRSC HFOs across brain states remains unknown. We aimed to answer these questions using in vivo, awake electrophysiological recordings in head-fixed mice that were trained to run for water rewards in a 1D virtual environment. We show that gRSC synaptic currents supporting HFOs, across all awake brain states, are exclusively localized to layer 2/3 (L2/3), even when events are detected within layer 5 (L5). Using focal optogenetics, both L2/3 and L5 can generate induced HFOs given a strong enough broad stimulation. Spontaneous gRSC HFOs occurring outside of SPW-Rs are highly comodulated with medial entorhinal cortex (MEC) generated high gamma in hippocampal stratum lacunosum moleculare. gRSC HFOs may serve a necessary role in communication between the hippocampus during SPW-Rs states and between the hippocampus, gRSC, and MEC during theta states to support memory consolidation and memory encoding, respectively. / Doctor of Philosophy / As an animal moves through an environment, individual neurons in the hippocampus, known as place cells, increase and decrease their firing rate as the animal enters and exits specific locations in the environment. Within an environment, multiple neurons become active in different locations, this cooperation of spiking in various locations creates a place map of the environment. Now let's say when the animal moved from one corner of the environment to another, place cells 'A', 'C', 'B', 'E', and 'D' became active in that order. This means, at any given point in the environment, the animal is standing in a venn-diagram-esque overlap of place fields, or locations individual place cells represent. A key question that entranced researchers for many years was how do these neurons know when to be active to not impinge on their neighbor's locations? The answer to this question rested with population electrical activity, known as the local field potential (LFP), that place cell activity is paced to. During active navigation through an environment, place cells activity is coupled to the phase of a slow ~8 hertz (Hz) theta oscillation. Within one theta cycle, or peak to peak, multiple place cells are active, representing the venn diagram of location the animal is in. Importantly, this theta activity and encoding of place cell activity is largely seen during active running or rapid eye movement (REM) sleep. During slow wave sleep (SWS), after an animal has experienced a specific environment and has created a place map, place cells are reactivated in the same order the animal experienced them in. From our previous example, the content of this reactivation would be the place cells 'A', 'C', 'B', 'E', and 'D' which all would be reactivated in that same order. These reactivations or replays occur during highly synchronous and fast LFP oscillations known as sharp wave-ripples (SPW-Rs). SPW-Rs are thought to be a key LFP event that drives memory consolidation and the eventual conversion of short-term memory into long-term memory. However, for consolidation to occur, connected cortical regions need to be able to receive and interpret the information within SPW-Rs. The granular retrosplenial cortex (gRSC) is one proposed region that serves this role. During SPW-Rs the superficial gRSC has been shown to exhibit high frequency oscillations (HFOs), which potentially serve the purpose for interpreting SPW-R content. However, HFOs have been reported during hippocampal theta, suggesting HFOs serve multiple purposes in interregional communication across different states. In this study, we found that naturally occurring gRSC HFOs occur exclusively in layer 2/3 across all awake brain states. Using focal optogenetic excitation we were able to evoke HFOs in both layer 2/3 and 5. Spontaneous gRSC HFOs occurring without SPW-Rs were highly comodulated with medial entorhinal cortex (MEC) generated high gamma in hippocampal stratum lacunosum moleculare. gRSC HFOs may serve a general role in supporting hippocampo-cortical dialogue during SPW-R and theta brain states to support memory consolidation and encoding, respectively.

This thesis deals with modeling, simulation and implementation of Load Commutated SCR based current source Inverter (LCI) fed squirrel cage induction motor drive with sinusoidal voltage and sinusoidal current. In the proposed system, the induction motor is fed by an LCI. A three level diode clamped voltage source inverter (VSI) is connected at the motor terminal with ac chokes connected in series with it. The VSI currents are controlled in such a manner that it injects the reactive current demanded by the induction motor and the LCI for successful commutation of the SCRs in the LCI. Additionally, it absorbs the harmonic frequency currents to ensure that the induction motor draws sinusoidal current. As a result, the nature of the motor terminal voltage is also sinusoidal. The concept of load commutation of the SCRs in the LCI feeding an induction motor load is explained with necessary waveforms and phasor diagrams. The necessity of reactive compensation by the active filter connected at the motor terminal for the load commutation of the thyristors, is elaborated with the help of analytical equations and phasor diagrams. The requirement of harmonic compensation by the same active filter to achieve sinusoidal motor current and motor voltage, is also described. Finally, to achieve the aforementioned induction motor drive, the VA ratings of the active filter (VSI) and the CSI with respect to VA rating of the motor, are determined theoretically. The proposed drive scheme is simulated under idealized condition. Simulation results show good steady state and dynamic response of the drive system. Load commutation of the SCRs in the LCI and the sinusoidal profile of motor current and voltage, have been demonstrated. As in LCI fed synchronous motor drives, a special mode of operation is required to run up the induction motor from standstill. As the SCRs of the LCI are load commutated, they need motor terminal voltages for commutation. At standstill these voltages are zero. So, a starting strategy has been proposed and adopted to start the motor with the aid of the current controlled VSI to accelerate until the motor terminal voltages are high enough for the commutation of the SCRs in the LCI. The proposed drive is implemented on an experimental setup in the laboratory. The IGBT based three level diode clamped VSI has been fabricated following the design of the standard module in the laboratory. A generalized digital control platform is also developed using a TMS320F2407A DSP. Two, three phase thyristor bridges with necessary firing pulse circuits have been used as the phase controlled rectifier and the LCI respectively. Appropriate protection scheme for such a drive is developed and adopted to operate the drive. Relevant experimental results are presented. They are observed to be in good agreement with the simulation results. The effect of capacitors connected at the output of the LCI in the commutation process of the SCRs in the LCI is studied and analyzed. From the analysis, it is understood that the capacitors form a parallel resonating pair with filter inductor and the motor leakage inductance, which results in an undesired oscillation in the terminal voltage during each of the commutation intervals leading to commutation failure. So, in the final system, the capacitors are removed to eliminate any chance of commutation failure of the SCRs in the LCI. It is shown by experiment that the commutation of the SCRs takes place reliably in the absence of the capacitors also. The commutation process is studied and analyzed without the capacitors to understand the motor terminal voltage waveform of the experimental results.

Bioimpedance spectroscopy is very useful in biomedical field as a safe and non-invasive technique. A stable and safe excitation current below than 0.5 mA for load impedances changing from 100 Ω to 10 kΩ in the full β-dispersion range from kHz up to 1 MHz is a big challenge for the design of the current source addressed by this thesis. For a good stability and high accuracy, the source should have a high output impedance. Different current source types in “current-mode approach” and “voltage-mode approach” were investigated and compared for usability in bioimpedance measurement systems. The “voltage-mode approach” with grounded load was proven to be more suitable and stable for biomedical measurements. Thereby the Tietze and the Howland circuit in dual configuration with negative feedback have shown the lowest error of the output current and the highest output impedance, where the improved Howland circuit in dual configuration with negative feedback is preferred because it has a simple structure, high accuracy and good stability. We suggest to improve the stability of the Howland circuit in dual configuration with negative feedback by introducing compensated operational amplifiers and to reduce stray capacitances at higher frequencies by adding gain compensation capacitor. We reach thereby an accuracy of 0.5% at low frequency and 0.9% at 1 MHz. With the realized accuracy of the designed voltage controlled current source, one decisive prerequisite for portable bioimpedance measurement system is achieved. In order to select the appropriate excitation signals for short measurement time, a comparative study of signals and their parameters was carried out. It leads to the selection of binary chirp signal as a suitable excitation signal due to its short measurement time about 100 μs, low crest factor lower than 2.8 and an energy efficiency higher than 54% in a very noisy signal. Simulation results show that the designed enhanced Howland current source excited by the binary chirp signal has low error and flatness in the whole range. / Die Bioimpedanzspektroskopie gewinnt aufgrund ihrer besonderen Eigenschaften als nicht-invasive, schonende Messmethode zunehmend an Bedeutung im biomedizinischen Bereich. Dabei ergeben sich besondere erausforderungen für den Entwurf der Stromquelle zur Realisierung eines stabilen und sicheren Anregungsstroms. Gefordert ist eine hohe Genauigkeit bis zu einem Maximalstrom von 0.5 mA in einem Frequenzbereich, der der β-Dispersion entspricht, von wenigen kHz bis hin zu 1 MHz. Die Stabilität muss bei variablen Lastimpedanzen im Bereich von 100 Ω bis 10 kΩ gewährleistet sein. Dafür muss die Stromquelle eine hohe Ausgangsimpedanz aufweisen. Diese Arbeit fokussiert auf den Entwurf von spannungsgesteuerten Stromquellen. Verschiedene Arten von Stromquellen wurden untersucht und verglichen. Der "Voltage-Modus-Ansatz" mit Masse-referenzierter Last hat sich als besser geeignet und stabiler für biomedizinische Messungen erwiesen. Die Tietze-Schaltung und diese Howland-Schaltung zeigen dabei die niedrigsten Fehler des Ausgangsstroms und die höchste Ausgangsimpedanz. Im direkten Vergleich besitzt die verbesserte Howland-Schaltung doch eine einfachere Struktur, höhere Genauigkeit und bessere Stabilität und wird daher gegenüber der Tietze-Schaltung bevorzugt. Um weitere Stabilitätsverbesserungen bei der Howland-Schaltung zu erreichen, werden zwei Maβnahmen vorgeschlagen. Zum einen werden kompensierte Operationsverstärker eingeführt und zum anderen wird der Einfluss von Streukapazitäten bei hohen Frequenzen minimiert indem die Verstärkung mit Kondensatoren kompensiert wird. Durch diese Maβnahmen wird eine Genauigkeit von 0.5% bei niedrigen Frequenzen und 0.9% bei 1 MHz ermöglicht. Mit dem neuen Entwurf der spannungsgesteuerten Stromquelle ist ein entscheidender Meilenstein für die Realisierung tragbarer Messsysteme der Bioimpedanz erreicht. Um eine kurze Messzeit zu realisieren wurde eine vergleichende Studie von Anregungssignalen und deren Signalparameter durchgeführt. Die Ergebnisse zeigen, dass binäre Chirp-Signale aufgrund der reduzierten Messzeit, des niedrigen Crest-Faktors unter 2.8 und hohe Energieeffizienz von mehr als 54% bei hohem Rauschlevel besonders geeignet sind. Simulationsergebnisse zeigen, dass die entwickelte Howland-Stromquelle zusammen mit einem binären Mehrfrequenzsignal den geringsten Amplitudenfehler im gesamten Frequenzbereich realisiert.

The interaction of an HVDC converter with the connected power system is of complex nature. An accurate model of the converter is required to study these interactions. The use of analytical small-signal converter models provides useful insight and understanding of the interaction of the HVDC system and the connected system components. In this thesis analytical models of the HVDC converters are developed in the frequency-domain by calculating different transfer functions for small superimposed oscillations of voltage, current, and control signals. The objective is to study the dynamic proprieties of the combined AC-DC interaction and the interaction between different HVDC converters with small signal analysis. It is well known that the classical Bode/Nyquist/Nichols control theory provides a good tool for this purpose if transfer functions that thoroughly describe the 'plant' or the 'process' are available. Thus, there is a need for such a frequency-domain model. Experience and theoretical calculation have shown that voltage/power stability is a very important issue for an HVDC transmission link based on conventional line-commutated thyristor-controlled converters connected to an AC system with low short circuit capacity. The lower the short circuit capacity of the connected AC system as compared with the power rating of the HVDC converter, the more problems related to voltage/power stability are expected. Low-order harmonic resonance is another issue of concern when line-commutated HVDC converters are connected to a weak AC system. This resonance appears due to the presence of filters and shunt capacitors together with the AC network impedance. With a weak AC system connected to the HVDC converter, the system impedances interact through the converter and create resonances on both the AC- and DC-sides of the converter. In general, these resonance conditions may impose limitations on the design of the HVDC controllers. In order to improve the performance of the HVDC transmission system when it is connected to a weak AC system network, a reactive compensator with a voltage source converter has been closely connected to the inverter bus. In this thesis it is shown that the voltage source converter, with an appropriate control strategy, will behave like a rotating synchronous condenser and can be used in a similar way for the dynamic compensation of power transmission systems, providing voltage support and increasing the transient stability of the converter. / QC 20100708

Laser Diodes (LDs) are semiconductor coherent lightening devices which are widely used in many fields such as defence, industry, medical and optical communications. They have advantageous characteristics such as having higher electrical-to-optical and optical-to-optical conversion efficiencies from pump source to useful output power when compared to flash lamps, which makes them the best devices to be used in range finding applications. Optical output power of lasers depends on current through LDs. Therefore, there is a relationship between operating life and work performance of LDs and performance of drive power supply. Even, weak drive current, small fluctuations of drive current can result in much greater fluctuations of optical output power and device parameters which will reduce reliability of LDs. In this thesis, a hardware for a fast and high power pulsed LD driver is designed for laser range finder and is based on linear current source topology. The driver is capable of providing pulses up to 120A with 250&mu / s pulse width and frequencies ranging from 20Hz to 40Hz. It provides current pulses for two LD arrays controlled with a proportional-integral (PI) controller and protect LDs against overcurrents and overvoltages. The proposed current control in the thesis reduces current regulation to less than 1% and diminishes overshoots and undershoots to a value less than 1% of steady-state value, which improves safe operation of LDs. Moreover, protection functions proposed in the thesis are able to detect any failure in driver and interrupt LD firing immediately, which guarantees safe operation of LDs.

Submitted by Morgana Silva (morgana_linhares@yahoo.com.br) on 2016-07-26T18:10:50Z No. of bitstreams: 1 arquivototal.pdf: 2752063 bytes, checksum: 886fc73f7f66099f1e033937798f6b7e (MD5) / Made available in DSpace on 2016-07-26T18:10:50Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2752063 bytes, checksum: 886fc73f7f66099f1e033937798f6b7e (MD5) Previous issue date: 2016-02-29 / This paper presents a block diagram modeling of a grid-independent photovoltaic power generation system, including the steps of DC regulation, voltage inversion, and control system based on dynamic simulations in Simulink / Matlab® exclusively using the built-in blocks available in its library. A well-known technique in literature called MPPT (maximum power point tracking) was used for tracking the maximum power of the photovoltaic generation. However, the control that was used to maintain a constant output voltage of the Push-Pull is based on a method that is similar to the MPPT, which configures a novelty of this research. The integration of modeling the entire PV system with these control systems is carried out in Simulink for investigaton and production of simulation results. An experimental platform that includes an emulator of photovoltaic panels, a 1 kW Push-Pull converter, a three-phase inverter with three arms and a hydraulic load constituided by a motor-pump was built in the laboratory. The experimental results corroborate the methodology that was used. / Este trabalho apresenta uma modelagem em diagramação de blocos de um sistema de geração de energia fotovoltaico isolado, incluindo as etapas de regulação CC, inversão de tensão e sistema de controle com base em simulações dinâmicas no ambiente Simulink/Matlab® utilizando, exclusivamente, os blocos built-in disponíveis em sua biblioteca. Uma técnica bem conhecida na literatura foi utilizada para o rastreio da máxima potência da geração fotovoltaica. No entanto, o controle utilizado para manter a tensão de saída constante do Push-Pull é baseado num método similar ao do rastreio da máxima potência, o que configura uma novidade deste trabalho. A integração da modelagem de todo o sistema fotovoltaico com estes sistemas de controle é realizada no ambiente Simulink para averiguação e produção dos resultados de simulação. Uma plataforma experimental que inclui um emulador de painéis fotovoltaicos, um Push-Pull de 1 kW de potência, um inversor trifásico de três braços e uma carga hidráulica constituída por um motobomba foi construída em laboratório. Os resultados experimentais corroboram a metodologia utilizada.

This work deals with the description and analysis of suitable methods for measurement of non-periodical high-level current pulses. For pulsed current source design and development a suitable measurement system is required. In this work shunt resistor, Rogowski sensor and magneto-optic sensor are presented. The analysis of their properties is performed in order to design a suitable sensor for test current pulse measurement. A design of Rogowski coil sensor has been made. An experimental measurement of current pulses with short time relations has been performed. The suitability of the coil sensor for non-harmonic waveforms measurement has been evaluated on the basis of measurement results. In case of the magneto-optic sensor a concept utilizing an optical fiber has been proposed. The design of the sensor has been performed also. Individual parts of the sensor were verified. Experimental magneto-optic sensors have been built and their properties have been studied.

This master’s thesis is an introduction to the measurement of changes in tissue impedance of blood flow by impedance plethysmography. Other chapters deal with the kinds of plethysmographs and their principles. The aim is to draft four-electrode impedance plethysmograph to measure changes in tissue impedance depending on blood flow. First, describe the individual blocks of the medical instrument. The practical part of the master’s thesis involves circuit design four-electrode plethysmograph. Given that a very important role in its function plays a constant current source operating at a frequency of 60kHz, this subset was implemented and verified its correct function. To draw component schemes used program EAGLE version 5.10.0.

Cieľom predloženej diplomovej práce je numerické riešenie šírenia elektromagnetických vĺn v tuneli. Za týmto účelom bola sformulovaná integrálna rovnica a numericky riešená pomocou metódy hraničných prvkov (BEM). Implementácia v prostredí MATLAB sľubne poukazuje na nízke výpočtové nároky oproti štandardným diferenciálnych diskretizačným metódam. Súčasťou projektu je vykreslenie rozloženia elektromagnetického poľa pre rôzne profily tunelov. Overenie výsledkov je vykonané pomocou zjednodušeného analytického modelu. V rámci práce je pozorované štúdium vplyvov zmien profilu tunela a rôznych impedančných podmienok na stenách tunela na výsledné rozloženie elektromagnetického poľa vo vnútri tunela.

Bioimpedance spectroscopy is very useful in biomedical field as a safe and non-invasive technique. A stable and safe excitation current below than 0.5 mA for load impedances changing from 100 Ω to 10 kΩ in the full β-dispersion range from kHz up to 1 MHz is a big challenge for the design of the current source addressed by this thesis. For a good stability and high accuracy, the source should have a high output impedance. Different current source types in “current-mode approach” and “voltage-mode approach” were investigated and compared for usability in bioimpedance measurement systems. The “voltage-mode approach” with grounded load was proven to be more suitable and stable for biomedical measurements. Thereby the Tietze and the Howland circuit in dual configuration with negative feedback have shown the lowest error of the output current and the highest output impedance, where the improved Howland circuit in dual configuration with negative feedback is preferred because it has a simple structure, high accuracy and good stability. We suggest to improve the stability of the Howland circuit in dual configuration with negative feedback by introducing compensated operational amplifiers and to reduce stray capacitances at higher frequencies by adding gain compensation capacitor. We reach thereby an accuracy of 0.5% at low frequency and 0.9% at 1 MHz. With the realized accuracy of the designed voltage controlled current source, one decisive prerequisite for portable bioimpedance measurement system is achieved. In order to select the appropriate excitation signals for short measurement time, a comparative study of signals and their parameters was carried out. It leads to the selection of binary chirp signal as a suitable excitation signal due to its short measurement time about 100 μs, low crest factor lower than 2.8 and an energy efficiency higher than 54% in a very noisy signal. Simulation results show that the designed enhanced Howland current source excited by the binary chirp signal has low error and flatness in the whole range. / Die Bioimpedanzspektroskopie gewinnt aufgrund ihrer besonderen Eigenschaften als nicht-invasive, schonende Messmethode zunehmend an Bedeutung im biomedizinischen Bereich. Dabei ergeben sich besondere erausforderungen für den Entwurf der Stromquelle zur Realisierung eines stabilen und sicheren Anregungsstroms. Gefordert ist eine hohe Genauigkeit bis zu einem Maximalstrom von 0.5 mA in einem Frequenzbereich, der der β-Dispersion entspricht, von wenigen kHz bis hin zu 1 MHz. Die Stabilität muss bei variablen Lastimpedanzen im Bereich von 100 Ω bis 10 kΩ gewährleistet sein. Dafür muss die Stromquelle eine hohe Ausgangsimpedanz aufweisen. Diese Arbeit fokussiert auf den Entwurf von spannungsgesteuerten Stromquellen. Verschiedene Arten von Stromquellen wurden untersucht und verglichen. Der 'Voltage-Modus-Ansatz' mit Masse-referenzierter Last hat sich als besser geeignet und stabiler für biomedizinische Messungen erwiesen. Die Tietze-Schaltung und diese Howland-Schaltung zeigen dabei die niedrigsten Fehler des Ausgangsstroms und die höchste Ausgangsimpedanz. Im direkten Vergleich besitzt die verbesserte Howland-Schaltung doch eine einfachere Struktur, höhere Genauigkeit und bessere Stabilität und wird daher gegenüber der Tietze-Schaltung bevorzugt. Um weitere Stabilitätsverbesserungen bei der Howland-Schaltung zu erreichen, werden zwei Maβnahmen vorgeschlagen. Zum einen werden kompensierte Operationsverstärker eingeführt und zum anderen wird der Einfluss von Streukapazitäten bei hohen Frequenzen minimiert indem die Verstärkung mit Kondensatoren kompensiert wird. Durch diese Maβnahmen wird eine Genauigkeit von 0.5% bei niedrigen Frequenzen und 0.9% bei 1 MHz ermöglicht. Mit dem neuen Entwurf der spannungsgesteuerten Stromquelle ist ein entscheidender Meilenstein für die Realisierung tragbarer Messsysteme der Bioimpedanz erreicht. Um eine kurze Messzeit zu realisieren wurde eine vergleichende Studie von Anregungssignalen und deren Signalparameter durchgeführt. Die Ergebnisse zeigen, dass binäre Chirp-Signale aufgrund der reduzierten Messzeit, des niedrigen Crest-Faktors unter 2.8 und hohe Energieeffizienz von mehr als 54% bei hohem Rauschlevel besonders geeignet sind. Simulationsergebnisse zeigen, dass die entwickelte Howland-Stromquelle zusammen mit einem binären Mehrfrequenzsignal den geringsten Amplitudenfehler im gesamten Frequenzbereich realisiert.