Global ETD Search

31	Effectiveness of Novel Compounds at Inhibiting and Killing Acinetobacter baumannii Biofilms Latimer, Keye S. 20 September 2012 (has links) No description available. Microbiology Biofilm Acinetobacter Cytotoxicity
32	Adrenoceptor modulation of the generation of cell-mediated cytotoxicity Hatfield, Stephen Marshall January 1988 (has links) This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu). Adrenaline Cell-mediated cytotoxicity Receptors, Adrenergic Cytotoxicity, Immunologic
33	Immune modulation by human cytomegalovirus following reactivation in immunocompromised patients Lepper, Mark William January 1999 (has links) No description available. 615.1
34	Studies on escherichia coli 0157:H7 and its toxins Zin, Noraziah Mohamad January 2001 (has links) No description available. 610
35	In vitro investigation into the role of human intrahepatic biliary epithelial cells as targets in primary biliary cirrhosis Ayres, Reuben Christopher Simon January 1993 (has links) No description available. 610
36	Evaluation of the role of monoclonal antibodies m17-1A, c17-1A and cSF25 in antibody-dependent cell-mediated cytotoxicity and an exploration of the possible mechanisms of action Pullyblank, Anne Maria January 1998 (has links) No description available. 610 Tumour cells; Cytotoxicity; Immunology
37	An investigation of the role of thymidine phosphorylase in the activation of 5-fluorouracil in colon tumour cell lines Milne, Lesley Helen January 1998 (has links) No description available. 610 Cancer; TP; Platelets; Cytotoxicity
38	Regulation of FasL expression and trafficking in cytotoxic T lymphocytes He, Jinshu 11 1900 (has links) Cytotoxic T lymphocytes (CTL) are differentiated CD8+ T cells that eliminate virally infected cells and tumor cells. CTL lyse target cells by at least two distinct mechanisms: degranulation of cytolytic molecules and cell surface expression of Fas ligand (FasL), which induces apoptosis of Fas-expressing target cells. In addition to their defense function, these two cytolytic mechanisms also play crucial roles in homeostatic regulation and contribute to pathogenesis in many different model systems. To fully exploit killer cells in tumor and virus elimination, or dampen the immune response in, for example, autoimmune diseases, it is essential to understand the mechanisms that CTL employ to destroy target cells. In contrast to the well-characterized degranulation mechanism, the regulation of FasL expression on the CTL cell surface remains elusive and even controversial. The prevailing model at the time I initiated my studies was that FasL is stored in cytolytic granules and that FasL cell surface expression would be subject to the same controls as degranulation. In this thesis, I revealed for the first time that there are two waves of FasL cell surface expression upon target cell engagement, which are differentially regulated by TCR signaling and perform distinct roles in CTL mediated responses. I demonstrated that CTL degranulation and FasL lytic mechanisms are fully independent with respect to stored component localization and regulation. Finally, based on cell fractionation and imaging studies, I suggested that FasL is stored in a recycling endosome associated compartment, which is located in a special niche between the ER and mitochondria and uses a novel microtubule-independent secretory mechanism to translocate to the cell surface. Together, these findings provide important insight into the regulation and role of FasL in CTL mediated responses. / Immunology Fas ligand T cells cytotoxicity
39	Chemical Constituents and Cytotoxicities of the Formosan Soft Corals Sarcophyton crassocaule, Tubipora musica Linneaus and Clavularia inflata Huang, Mingjae 14 July 2004 (has links) Chromotographic separations of Formosan soft coral Sarcophyton crassocaule (GN-55) led to the isolations of four diterpenes, sarcophine (1), sarcophytoxide (2), (7R, 8S)-dihydroxysarcophytonin A (3), sarcophtonin A (4), one steroid, 17 cytotoxicity antitumor marine soft coral
40	Molecular mechanisms of acrolein-mediated cytotoxicity Kern, Julie Christine 28 August 2008 (has links) Not available / text Acrolein--Toxicology Cell-mediated cytotoxicity

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