Force-free equilibria are believed to be important in both an astrophysical and a laboratory context as minimum-energy configurations (see, for example, Woltjer, 1958; Taylor, 1974). Associated is the study of magnetic helicity and its invariance. In Chapter Two of this thesis we put forward a means of heating the corona by the rotation of the foot-points of a coronal "sunspot" magnetic field anchored in the photosphere. The method adopted is essentially that of Heyvaerts and Priest (1984), employing Taylor's Hypothesis (Taylor, 1974) and a magnetic helicity evolution equation. A characteristic of the Reversed-Field Pinch device is the appearance, at high enough values of the quantity "volt-seconds over toroidal flux", of a helical distortion to the basic axi-symmetric state. In Chapter Three we look for corresponding behaviour in the "sunspot equilibrium" of the previous chapter, with limited success. However, we go on to formulate a method of calculating general axi-symmetric fields above a sunspot given the normal field component at the photosphere. Chapters Four, Five and Six are concerned with equilibrium force-free fields in a sphere. The main aim here is the calculation minimum-energy configurations having magnetic flux crossing the boundary, and so we employ "relative helicity" (Berger and Field, 1984). In Chapter Four we consider the "P1(cosθ)" boundary radial field, finding that the minimum-energy state is always purely symmetric. In Chapter Five we treat the "P2(cosθ)" boundary condition. We find in this case that a "mixed state" is theoretically possible for high enough values of the helicity. In Chapter Six, we consider a general boundary field, which we use to model point sources of magnetic flux at the boundary of a spheromak, finding that in practice an axi-symmetric configuration is always the minimum-energy state. Finally, in Chapter Seven we present an extension to the theorem of Woltjer (1958), concerning the minimization of the magnetic energy of a magnetic structure, to include the case of a free boundary subjected to external pressure forces. To illustrate the theory, we have provided three applications, the first to a finite cylindrical flux and the remainder to possible spheromak configurations.

Purpose: The purpose of this work was to compare and analyse two clinically measurable beam quality specifiers, the half value layer (HVL) and the ratio of the doses at depths 2 cm and 5 cm (D2/D5) for a range of kilovoltage modalities, and to determine whether a practical, alternative and/or better correlation exists. Methods and materials: Four x-ray units were used: two Philips RT 250 units, a Pantak HF 420 operated up to 250 kV, and a D3300 Gulmay Medical unit operated up to 300 kV. As not all these units were equipped with an internal monitor chamber, a system was used where either the first measurement was repeated at the end of each series or an external monitor chamber was employed in order to ensure output constancy. A range of HVL’s were measured on each of the energies investigated on this work, which were used clinically. A calibrated 0.6 cc ionization chamber was used in a 30 cm x 30 cm x 30 cm water phantom to measure the absorbed dose to water at depths 2 cm and 5 cm in order to investigate D2/D5 as the alternative quality index. Results: The effectiveness of using a monitor chamber in the determination of HVL has been shown to be significant in this work where HVLs differed by up to 3%. Errors incurred from using HVL have been identified. This work verified that the ratio of doses at depths 2 cm and 5 cm in water could be applied as a kilovoltage beam quality specifier in the clinical environment at low and medium energies with a well defined FSD and field size. Conclusions: The use of D2/D5 as a tool to verify the beam quality index would simplify quality control in the clinical environment. Further work would have to be done to investigate other energies. Lower energies may require the use of shallower depths in order to improve accuracy and ensure a more clinically relevant setup.

The maximum target material spray velocity emanating from the rear of a penetrated thin target is studied utilizing the one-dimensional shock-wave theory. A set of experiments is designed to evaluate the analytical results. The targets are 0.0025-cm-thick 1100 aluminum foil and 0.041-cm-thick 1100 Hl4 aluminum plate. The projectiles are made of tungsten and disk shaped. Their diameter is 0.56 em and their thickness is either 0.076 or 0.038 cm. The projectile and target dimensions assure that the one-dimensional assumptions in the theory are valid.. The impact velocity range is from 0.089 to 0.295 cm/µsec. A method is developed to launch unskewed and intact very dense disk-shaped projectiles to high velocity. By using very dense tungsten projectiles the maximum aluminum target material spray velocity is as predicted by the theory well in excess of the projectile impact velocity. A ratio is defined as the maximum target material spray velocity to projectile impact velocity. The experimental ratio points are seen to agree with the predicted values for the impact velocity range covered. Photographic data are presented and analyzed for the fragmentation of material on the leading edge of the target material spray cloud. As the impact velocity is increased the complete fragmentation of material on the leading edge is shown in the photographic data. / Master of Science

A multi-disciplinary, high resolution, geophysical investigation of a Scottish Sea loch has facilitated both the reconstruction of a detailed late Quaternary para-stratigraphic model and the critical assessment of the acquisition and analytical methodologies most appropriate for the study of submerged palaeo-glaciomarine environments. Loch Ainort, situated on the eastern coast of the Isle of Skye, has been surveyed using a 192 kHz echosounder, a 400 kHz side scan sonar and a 3.5 kHz sub-bottom profiler. Lithological calibration was provided by the analysis of both in situ core data and extant terrestrial data sets. It is proposed that for the effective reconstruction of these and any other nearshore palaeo-environments a multi-disciplinary geophysical approach is essential. The critical control on success is the adherence, during interpretation, to a single unifying seismo-analytical framework. The seismo-stratigraphical analysis technique has been adapted for high- resolution work in order to provide this rigid framework. Objective descriptive analysis of the seismic traces provides a "seismic para-stratigraphy" which when combined with lithological data is used to construct a "composite para-stratigraphy". This is a process based, litho-stratigraphic interpretation that, by virtue of the detailed spatial extent afforded it by geophysical data, can be placed in a wider environmental context. The composite para-stratigraphy for the Loch Ainort basin is dominated by Loch Lomond Stadial glacial activity. Terminal and readvance limits are identified at several localities within the basin. Variable morphological styles of the glacial sequences show that deglaciation occurred in two distinct, climatically controlled, phases. The first marked by a fluctuating ice margin and the second by uninterrupted retreat and in situ ice stagnation. Sub-aerially induced debris flows occur during the initial paraglacial phase but stabilisation of exposed slopes restricts this input and rapid sedimentation of fines from sediment-rich meltwaters becomes dominant. Modern fjordic sedimentation develops after the disappearance of glacier ice.

Philosophers who work on time often ignore the implications their doctrines have for the common sense intuition that the past is fixed and the future not. Similarly, those who work on fatalism, and whose arguments often imply an assertion or denial of the common sense intuition, rarely take into account the implicit dependence their arguments have upon specific theories of time. I take the intuition, and its relation to the nature of time, seriously. In Part I of my thesis, I investigate the relations between the dynamic and static theories of time, on the one hand, and the intuition, on the other. I argue that the so called 'pure' forms of these theories, inasmuch as they both posit an ontological temporal symmetry, cannot do justice to the intuition. The 'pure' B-Theory, with its denial of objective temporal becoming, cannot allow for a robust sense in which the future is non-fixed. The 'pure' A-Theory, according to which only the present exists, acknowledges the robustness of the asymmetry, but cannot provide a ground for it. I conclude Part I of my thesis with the claim that only a conception of time according to which the past exists and the future does not, can account for the intuition. In Part II, I discuss those fatalistic arguments which rely upon the determinateness of future truth as their key premise, and argue that these fail either because they rely on an illegitimate modal concept, or because they rely on a key undefended assumption. Finally, in the Epilogue, I provide a more detailed sketch of the account of time posited at the end of Part I, and suggest that it can also provide a more thoroughgoing rejection of the logical fatalistic argument.

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No description available.

China has now become the largest producer and exporter of textile and clothing products in the world. The objective of this research is to explore the relationship between the complicated interactive process of institutional change and the development of industrial clusters in China. It focuses on the distinctive institutional factors that have allowed the textile and clothing clusters in China to benefit from globalisation while those in other transitional economies have not done so. The research also aims to make a thorough investigation into how the dynamic change of the public-private interface has influenced the development and upgrading of the textile and clothing clusters in contemporary China-in-transition, with all the political and social implications that the process entails. The research mainly uses the New Institutional Economics Approach (NIE) and gives weight to institutional change through multiple case studies of textile and clothing clusters in Zhejiang province, East China. The micro case studies are effective in illustrating the interaction between institutional change and industrial development. The research argues that the unique institutional factors leading to the rapid development of textile and clothing clusters in China include hybrid ownership, public entrepreneurship and the specialised wholesale market. The research has also shown that the theory of local state corporatism alone fails to explain the great success of textile and clothing clusters in China. The development and upgrading of textile and clothing clusters in China has witnessed extraordinary institutional change through co-evolution between the public sector and the private sector, which can be reflected through the interaction among social networks, entrepreneurship and performance of local government. The flexibility in the public-private interface is one unique endogenous institutional arrangement embedded in the economic system in China. It is a dynamic process of institutional embeddedness, deembeddedness and reembeddedness with a diversity of economic regimes coexisting at different hierarchies of government

The use of ligand in transition-metal catalysed reactions has had a considerable impact. The present manuscript aims at showing the influence of ligands in the palladium catalysed Suzuki-Miyaura cross-coupling reaction. In chapter one, the mechanism of this reaction will be described based on the numerous contribution published in the literature. It will be shown that the electronic and steric properties of the ligands have a huge repercussion on the catalytic activity of the metal. In the second chapter, the electronic and steric properties of the widely used Buchwald-phosphine ligand will be investigated. For this purpose, bis-carbonyl iridium(I) complexes were synthesized and their characterization allowed determining their TEP (Tolman electronic parameter) and their buried volume %V[subscript(bur)]. Then three next chapters of this thesis will focus on the syntheses and characterizations of new palladium complexes bearing N-heterocyclic carbenes (NHC). Their design was made in a view to obtain high activity in cross coupling reaction, particularly in the Suzuki-Miyaura cross coupling. Their activation under the catalytic conditions leads to the formation of palladium(0) species that can be mono- or bis-ligated. The influence of the ligand on the catalyst activity will be discussed. A palladium(II) precatalyst leading to mono-ligated active species will be described. Its activity in cross-coupling is very good, since activated and non-activated aryl chlorides could be coupled with aryl boronic acids at room temperature using low catalyst loadings. Unfortunately, the catalyst activity decreased with temperature. This result showed the fragility of the mono-ligated active species. In a view to obtain more robust catalysts that can perform high turnover numbers, new palladium(II) precatalysts bearing two ancillary ligands were developed. Mixed systems NHC- phosphites and NHC-phosphines are described. NHC-phosphites precatalysts displayed very good activity, but the phosphites are unfortunately sensitive to reaction conditions, limiting their role of active species shield. NHC-phosphine bearing complexes were highly active and could perform up to 10,000 turnovers with unactivated aryl chlorides. Very interestingly, these catalysts were also able to couple benzylchlorides and allyl chlorides with a wide range of boronic acids at very low catalyst loadings. These reactions had also the great advantage to proceed in aqueous solvents at very high substrate concentration. The activation mechanism of these complexes was investigated. Dichloropalladium(II) complexes were reduced under the catalytic conditions to lead palladium(0) species. Therein, it is shown that this reduction step was rate-determining in catalysis. Some palladium(0) intermediates xxiv were synthesized and showed good to excellent activities at low temperature under the exact same conditions. They displayed high reactivity towards oxygen and moisture and have to be handled under inert atmosphere. A particular complex had the ability to react with molecular dioxygen to form a stable peroxo-complex. Interestingly, this complex displayed excellent activity in water under aerobic conditions. This system was of great advantage since the reaction could be set up under air using cheap and user-friendly reagents displaying low toxicity. Moreover, the readily available distilled water used as solvent did not require prior degassing. Symmetrical and unsymmetrical bis-NHC palladium(0) complexes were successfully synthesized. They display excellent activity in the Suzuki-Miyaura cross coupling and turnover frequencies as high as 300 could be obtained at room temperature with unactivated arylchlorides and arylboronic acids. These complexes were also found excellent catalysts for the coupling of benzylchlorides with arylboronic acids. Mechanistic studies showed that no ligand dissociation occurred during the coupling suggesting as bis-ligated active species.

L’une des caractéristiques électrophysiologiques majeure de la maladie de Parkinson est l’émergence de bouffées de potentiels d’action au niveau du noyau sous-thalamique (NST). Des travaux récents menés in vitro ont soulevé l’hypothèse de l’implication des récepteurs dopaminergiques D5 (RD5) dans la genèse de cette activité pathologique. Nous avons mis en évidence que les RD5, seuls récepteurs D1-like exprimés au niveau du NST, présentent une activité constitutive in vivo, et que celle-ci est bloquée par l’injection locale d’a-flupentixol. Le blocage de cette activité intrinsèque d’une part, améliore le comportement locomoteur d’animaux rendu hémiparkinsonien, et d’autre part réduit la tendance des neurones du NST à décharger en bouffées in vivo et in vitro, signature physiopathologique de la maladie de Parkinson. L’ensemble de ces données souligne le rôle clé des RD5 dans la physiopathologie de la maladie de Parkinson, ce qui ouvre la voie à de nouvelles approches thérapeutiques… Outre cette propriété d’agoniste inverse des RD5, l’a-flupentixol est connu pour ses propriétés antipsychotiques en tant qu’antagoniste des RD2. C’est pourquoi lorsqu’il est injecté de façon systémique il induit des troubles moteurs et une catalepsie caractérisés de syndrome extrapyramidaux, même chez les animaux contrôles. Les mécanismes électrophysiologiques qui sous-tendent cet état cataleptique n’ayant jamais été étudié auparavant, nous avons mis en évidence que l’administration, par voie intra-péritonéale, d’a- flupentixol induit des changements drastiques de l’activité électrique au sein du réseau des ganglions de la base. En effet, nous avons observé une augmentation de la fréquence de décharge des neurones du globus pallidus et une diminution de celle-ci au niveau du NST et de la substance noire pars reticulata, accompagnée d’une désorganisation de l’activité électrique au niveau de ces deux noyaux. Cette étude offre une vue d’ensemble sur les mécanismes électrophysiologiques à l’origine des effets secondaires extrapyramidaux induits par les antipsychotiques, et souligne le caractère fondamental de la désorganisation de l’activité électrique des ganglions de la base dans les troubles moteurs. / Burst-firing in the subthalamic nucleus (STN) is a hallmark of Parkinson’s disease. Previous in vitro studies have raised the hypothesis of the involvement of dopamine D5 receptor (D5R) in the genesis of this pathological activity. Here we have shown that D5R exert a constitutive activity in vivo, which can be blocked by local application of a-flupentixol. Blockade of this intrinsic activity improved locomotor behaviour in an animal model of Parkinson’s disease and alleviate burst-firing of STN neurons both in vitro and in vivo. Taken together, these results highlight the key role play by local D5R in the pathophysiology of Parkinson’s disease and open the way to new pharmacological treatment of the disease… In addition to this property D5R inverse agonist, a-flupentixol is known for its antipsychotic properties as a D2R antagonist. Therefore, when injected systemically, it induced motor disturbances and catalepsy characterized as extrapyramidal motor side-effects. The electrophysiological mechanisms underlying this cataleptic state had never been studied before. Here we have demonstrated that the intra-peritoneal administration of a-flupentixol induced dramatic changes in the electrical activity of the basal ganglia network. Indeed, we observed an increase in firing rate of globus pallidus neurons and a decrease in both STN and substantia nigra pars reticulata, accompanied by a disorganisation of the electrical activity of these two nuclei. This study provides an overview of the electrophysiological mechanisms underlying extrapyramidal motor side-effects induced by antipsychotics, and stresses the fundamental nature of the disorganisation of the electrical activity in the basal ganglia network as a source of movement disorders.