An increasing demand for providing accessible content to widely differentiated target groups calls for a universal eBook standard combined with a flexible user interface. For this purpose, we enhanced the current DAISY standard to serve the blind and visually handicapped as well as deaf, hearing impaired, dyslexic and elderly users. In addition to supporting sign language videos and alternatives in simplified language, we introduced videos with media enrichments as a primary source. Additionally a personalizable web player, based on the Adobe Flex Framework, allows real-time streaming and local playback of original and newly developed multimedia DAISY books. Furthermore, the player supports multimodal input such as gesture and speech recognition to facilitate use by physically handicapped people.