Doctor of Philosophy / This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Doctor of Philosophy / This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au

Reproduction de : Thèse d'exercice : Chirurgie dentaire : Nantes : 2008. / Bibliogr.

Thèse (M. Sc.)--Université Laval, 2003. / Bibliogr.: f. [140]-162. Publ. aussi en version électronique.

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Reproduction de : Thèse d'exercice : Chirurgie dentaire : Nantes : 2008. / Bibliogr.

Yes

Yes / From the early Medieval period, Christian monasteries were wealthy and powerful, and played a central role in both religious and political life. Those who entered the monasteries did so at the age of 7-8 years and were drawn from a wide range of social strata. From that point, they were subject to the dietary rules imposed by the rules of each monastic order. In order to assess the origins and diet of 10 monks who lived in the monastery of San Millán de la Cogolla Yuso (La Rioja, Spain) during the 17th – 18th century, collagen from small sections of human dentine (representing the childhood diet) and from ribs (an average of the last 5 - 10 years of adult diet) was measured to establish lifetime variations in the isotope ratios of carbon (δ13C) and nitrogen (δ15N). Bulk collagen δ13C (overall mean= -18.2‰ +/-0.4) and δ15N (overall mean= 12.6‰ +/-0.8) values from the ribs suggest 2 adult cohorts: one with a diet based on C3 plants and a high intake of protein from meat or dairy products and some marine resources and a second cohort with some C4 plant consumption alongside meat and dairy. Data from the dentine sections revealed different dietary patterns during the period of tooth formation among the monks, suggesting that 4 of them entered the monastery after consuming lower status diets during childhood. / This paper was written with the support of a PhD grant (BES-2015-075176) from the project CoChange (HAR2014-51830-P) lead by Prof. Pablo Arias.

A polpa dentária pode responder a uma agressão pela produção de dentina reacional e reparativa. Osteopontina (OPN), proteína abundante no osso, e proteína da matriz dentinária 1 (DMP1) podem estar presentes nessas dentinas. O objetivo do trabalho foi examinar a ultra-estrutura e a presença da OPN e DMP1 na dentina induzida pela extrusão de incisivos. Os incisivos de ratos foram extruídos e depois reposicionados. Após períodos de tempo determinados, as maxilas foram processadas para MET, MEV e imunocitoquímica. Após extrusão, houve formação de dentina reacional e reparativa, as quais variaram em aspecto, espessura e células secretoras. A OPN foi observada apenas na dentina reparativa num padrão semelhante ao encontrado no osso. A DMP1 foi detectada na matriz em mineralização de todas as dentinas estudadas, mas praticamente não foi observada nas suas pré-dentinas, o que confirmou o seu papel na mineralização. Tais achados mostraram que a dentina reparativa e o osso primário, além de semelhantes morfologicamente, são também similares com relação às suas composições / Reactionary dentine (Rc) and (Rp) reparative dentine are two strategies used by the dentine?pulp complex to respond to injury. Osteopontin (OPN) and dentine matrix protein 1 (DMP1) may be present in the matrix secreted after tissue injury. The aim of the present study was to examine the ultrastructure, as well as the presence of OPN and DMP1 in Rc and Rp by provoking extrusion of the rat incisor. The right upper incisors of rats were extruded and then repositioned. After certain periods of time, the maxillae were processed for scanning and transmission electron microscopy and for immunocytochemistry. After extrusive trauma, there was formation of Rc and Rp, which varied in aspect and thickness. OPN was only detected in the Rp in a pattern similar to bone. DMP1 was immunodetected in all the dentine types, but rare colloidal gold particles were observed in predentin, that confirmed its role in mineralization. The present findings showed that Rp shares some compositional characteristics with primary bone, especially in relation to its OPN content