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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Исследование окислительно-восстановительных превращений противовирусных веществ азоло-азинового ряда методами вольтамперометрии и ЭПР-спектроскопии : магистерская диссертация / Investigation of oxidation-reduction transformations of antiviral substances of the azolo-azine series by the methods of voltammetry and EPR spectroscopy

Баушева, А. В., Bausheva, A. V. January 2017 (has links)
Целью диссертационного исследования является изучение процессов восстановления нитрогруппы в препаратах азоло-азинового ряда с применением электрохимических методов и ЭПР-спектроскопии. Для достижения стабильных и воспроизводимых данных была разработана методика эксперимента. Рассмотрены вопросы электровосстановления фармпрепаратов содержащих нитрогруппу в своем строении и применение ЭПР – спектроскопии и электрохимических методов анализа, в частности вольтамперометрии, для установления механизма восстановления лекарственных веществ в теле человека. В ходе экспериментальной части установлена природа происходящих процессов, в том числе, природа лимитирующей стадии, проведен расчет количества электронов, принимающих участие в процессах электровосстановления основного вещества препаратов TRIAZAVIRIN® и TRIAZID®. Предложены вероятные механизмы протекания исследуемого процессов восстановления нитрогруппы исследуемых соединений. / The main substances of the newest Russian antiviral drugs, the aziolo-azine series TRIAZAVIRIN® and TRIAZID®, served as the research subjects. Objective: to study the processes of reduction of the nitro group in these compounds using electrochemical methods and EPR spectroscopy. An analysis of the literature data showed that the pharmaceutical activity of preparations containing a nitro group is due to its reduction. Electrochemical methods of analysis make it possible to study the in vitro transformation of the preparation as close as possible to the processes taking place with the drug in vivo. The method of EPR-spectroscopy allows obtaining reliable data on the free radical formed during the reaction, which can be a determining factor of the biological activity of the preparation. These methods were taken as a basis for studying the processes of nitro group reduction, which is a part of the basic substances of TRIAZAVIRIN® (TRZ) and TRIAZID® (TZ) preparations. The processes of nitro group reduction in TRZ and TZ molecules were studied using voltammetry and EPR spectroscopy. It has been established that the rate of reduction of the nitro group TRZ is controlled by diffusion, the process of reduction of the nitro group of the preparation is stepwise, irreversible and proceeds at a potential of -0.35 V through the formation of an anion radical with addition of 4e. It is shown that the rate of reduction of the nitro group of TZ is controlled by diffusion. The single-wave reduction process of the nitro group TZ at a potential of 6 -0.65 V is irreversible, goes through the formation of an anion radical with addition of 6e. Possible schemes for the recovery of the nitro group of the basic substances of TRIAZAVIRIN® and TRIAZID® preparations are proposed.

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