Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-10-30T10:52:58Z No. of bitstreams: 1 475957 - Texto Completo.pdf: 1765051 bytes, checksum: d50405a18587ae97ec45079b34e7561b (MD5) / Made available in DSpace on 2015-10-30T10:52:59Z (GMT). No. of bitstreams: 1 475957 - Texto Completo.pdf: 1765051 bytes, checksum: d50405a18587ae97ec45079b34e7561b (MD5) Previous issue date: 2015-03-30 / INTRODUCTION: One of the main postoperative complications of kidney transplant is delayed graft function (DGF), which means absence of graft function after transplant or the need for dialysis during the first week post procedure. The occurrence of DGF currently in our hospital is high and has been attributed to a combination of many factors. OBJECTIVE: to evaluate the factors associated to DGF and their influence in the outcome of kidney transplants. METHODS: historical cohort of 150 patients transplanted with live or deceased donor kidneys from 2011 to 2013. RESULTS: DGF was associated to time in dialysis and the number of recipient pre-transplant transfusions, donors age, serum creatinine level, use of vasoactive drugs in the donor, distance from place of organ retrieval and transplant center, and duration of cold ischemia time. DGF influenced post-transplantation outcome in regard to length of stay in intensive care, length of hospital stay, acute rejection episodes, and higher creatinine levels at discharge. Patients and graft survival were shorter in the DGF group. CONCLUSION: There are multiple factors related to DGF, the most important being those related to donors, and organ storage. The most important factor related to the recipient was the dialysis vintage. We did not find a correlation between DGF and HLA-compatibility. DGF consequences are important, including worse graft function and survival, as well as impact in recipient morbidity and mortality. / INTRODU??O: Uma das principais complica??es do p?s-operat?rio de transplante de rim ? a disfun??o precoce do enxerto (DPE) que significa a aus?ncia de fun??o do enxerto ap?s o transplante ou a necessidade de di?lise na primeira semana ap?s o procedimento. A ocorr?ncia de DPE em nosso Hospital, atualmente, ? elevada e tem sido atribu?da ao longo dos anos ? combina??o de diversos fatores. M?TODOS: coorte hist?rica com 150 pacientes transplantados de rim de doador vivo ou falecido de 2011-2013. OBJETIVOS: verificar os fatores associados ? DPE e a sua influ?ncia na evolu??o do transplante de rim. RESULTADOS: DPE foi associada com o tempo de di?lise e o n?mero de transfus?es realizadas pelo receptor no pr?-transplante, idade, valor da creatinina e utiliza??o de drogas vasoativas pelo doador, dist?ncia do ?rg?o doado e tempo de isquemia fria. Os valores de creatinina e pot?ssio no p?s-operat?rio, assim como o volume urin?rio foram determinantes para a realiza??o de di?lise ap?s o transplante. DPE influenciou na evolu??o do transplante em maior tempo de interna??o na UTI e no tempo de interna??o, epis?dios de rejei??o aguda e maior n?vel de creatinina no momento da alta hospitalar. A sobrevida do enxerto e do paciente foi menor no grupo de pacientes que apresentou DPE. CONCLUS?O: V?rios s?o os fatores relacionados ? DPE, em especial os relacionados aos doadores e com a preserva??o do ?rg?o. O principal fator atrelado ao receptor foi o tempo de di?lise. N?o encontramos rela??o na ocorr?ncia de DPE com a compatibilidade HLA. As consequ?ncias da DPE s?o importantes incluindo pior fun??o e sobrevida do enxerto, e tamb?m o impacto na morbidade e da mortalidade dos receptores.