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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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In Vitro Selection Of Dna Aptamers To Glioblastoma MultiformeBayrac, Abdullah Tahir 01 September 2011 (has links) (PDF)
Aptamer probes for specific recognition of glioblastoma multiforme were generated using a repetitive and broad cell-SELEX-based procedure without negative selection. The 454 sequencing technology was used to monitor SELEX, and
bioinformatics tools were used to identify aptamers from high throughput data. A group of aptamers were generated that can bind to target cells specifically with dissociation constants (K d ) in the nanomolar range. Selected aptamers showed high affinity to different types of glioblastoma cell lines, while showing little or no affinity to other cancer cell lines. The aptamers generated in this study have
potential use in different applications, such as probes for diagnosis and devices for targeted drug delivery, as well as tools for molecular marker discovery for glioblastomas.
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Electrochemical poly(ProDOT) dendritic DNA aptamer biosensor for signalling interferon gamma (IFN-ɣ) TB biomarkerSidwaba, Unathi January 2017 (has links)
Philosophiae Doctor - PhD / Tuberculosis (TB) is an infectious disease that, despite all efforts devoted towards its
eradication, remains a threat to many countries including South Africa. Current diagnostic
assays do offer better performance than the conventional sputum smear microscopy and
tuberculin skin tests. However, these assays have been proven to be affected by various factors
including the condition of an individual's immune system and vaccination history. By far,
electrochemical biosensors are amongst the currently investigated techniques to address the
shortcomings associated with these diagnostics. / 2020-08-31
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Development of DNA aptamer as a HMGA inhibitor for cancer therapy and NMR-based metabonomics studies in human/mouse cell linesWatanabe, Miki 05 December 2011 (has links)
No description available.
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