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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Propriedades das vari?veis antropom?tricas e laboratoriais como indicativas de doen?a hep?tica gordurosa n?o-alco?lica grave em indiv?duos com obesidade grau II e III

Berleze, Diovanne 14 April 2011 (has links)
Made available in DSpace on 2015-04-14T13:36:00Z (GMT). No. of bitstreams: 1 461548.pdf: 554767 bytes, checksum: a8061ad380e2b55b475c03df57b4c518 (MD5) Previous issue date: 2011-04-14 / Introduction : Obesity is a pandemic disease. Obesity grade II and III often needs invasive treatment such as bariatric surgery. In these patients, comorbidities are frequent, including the nonalcoholic fatty liver disease (NAFLD), characterized by fatty infiltration of the liver of nonalcoholic etiology in individuals without other chronic liver diseases. Objectives : This study aimed to evaluate the properties of a group of anthropometric and laboratory tests according to the diagnosis of severe liver damage. Patients and Methods : We studied 845 patients with body mass index of 35 or more, with data from liver biopsy. We evaluated the properties (sensitivity, specificity, PPV, NPV, LR + and LR-) of anthropometric and laboratory, compared to the biopsy, for diagnosis of severe liver damage. The variable was dichotomized NAFLD in severe liver damage or not. Results : The prevalence of severe liver damage was 38.1% (95% CI 34.8 to 41.4). The average age of the individuals was 37.2 years and mean weight was 131.0 kg and prevalence of NAFLD was 53.3% higher in men (95% CI 47.0 to 59.7) than in women 32.1% (95% CI 28.3 to 36.9). Conclusions : Among the anthropometric variables studied, the waist / hip ratio (WHR) was the best variable to classify patients with and without severe liver damage, followed by the waist. Transaminases showed better performance than the anthropometric variables, TGP being the best, followed in order by AST and GGT. / Introdu??o : A obesidade ? hoje uma pandemia. A obesidade grau II e III, s?o graus avan?ados de obesidade, que necessitam muitas vezes de tratamento invasivo como a cirurgia bari?trica. Nestes pacientes, ? freq?ente a presen?a de comorbidades, entre elas a Doen?a Hep?tica Gordurosa N?o Alco?lica (DHGNA), caracterizada por infiltra??o gordurosa do f?gado de etiologia n?o alco?lica em indiv?duos sem outras hepatopatias cr?nicas. Objetivos : Este estudo teve como objetivo avaliar as propriedades de um grupo de testes antropom?tricos e laboratoriais em fun??o do diagnostico de dano hep?tico grave. Pacientes e M?todos : Foram estudados 845 pacientes com ?ndice de massa corporal de 35 ou mais, com dados de bi?psia hep?tica. Foram avaliadas as propriedades (sensibilidade, especificidade, valor preditivo positivo, valor preditivo negativo, likelihood ratio positivo e likelihood ratio negativo) de vari?veis antropom?tricas e laboratoriais comparadas com a bi?psia, para diagn?stico de dano hep?tico grave. A vari?vel DHGNA foi dicotomizada em dano hep?tico grave ou n?o. Resultados : A preval?ncia de dano hep?tico grave foi de 38,1% (IC95% 34,8 41,4). A m?dia de idade dos indiv?duos avaliados foi de 37,2 anos e a m?dia de peso foi de 131,0 Kg. A preval?ncia de DHGNA foi maior nos homens 53,3% (IC95% 47,0 59,7) do que nas mulheres 32,1% (IC95% 28,3 36,9) Conclus?es : Dentre as vari?veis antropom?tricas estudadas a raz?o cintura quadril (RCQ) foi a melhor vari?vel para classificar os pacientes com e sem dano hep?tico grave, seguida da cintura. As aminotransferase apresentaram melhor desempenho do que as antropom?tricas sendo a melhor a ALT seguida em ordem pela AST e a GGT.

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