Made available in DSpace on 2014-06-11T19:31:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-05-21Bitstream added on 2014-06-13T19:01:22Z : No. of bitstreams: 1 martins_rcb_dr_arafcf.pdf: 1033721 bytes, checksum: c453fe7fa51bca1f3a487b85434b382d (MD5) / Unimep / O estado nutricional da população infantil é um indicador relevante de saúde e qualidade de vida da população. Entretanto, faltam estudos longitudinais que dêem conta de avaliar a evolução do estado nutricional num mesmo grupo populacional, que confiram maior confiabilidade aos resultados. Assim, o objetivo desta pesquisa é, a partir de quatro estudos transversais e um longitudinal, avaliar a evolução do estado nutricional de escolares de 1a a 4a séries da rede pública do ensino fundamental da área urbana do município de Piracicaba/SP, de 2003 a 2006. Nesse período foram realizadas 16068 avaliações, sempre no segundo semestre de cada ano, em 9683 escolares de 12 unidades de ensino situadas nas 5 regiões administrativas da cidade de Piracicaba. Esses grupos de escolares avaliados anualmente foram chamados de levantamentos transversais. Ao grupo de escolares (n=347) acompanhado da 1a a 4a série, durante o mesmo período dos estudos transversais chamou-se grupo longitudinal. Foram aferidos o peso e a estatura e levantados dados de identificação pessoal (nome completo, sexo, data de nascimento, série e turma na escola). Os dados foram processados pelo programa Epi-info adotando-se a população de referência do NCHS/CDC - National Center Health Statistics/ Centers for Disease control and prevention - 2000 e expressos em escore-Z (Z) e percentil (P) dos indicadores de estatura para idade (E/I), peso para idade (P/I) e índice de massa corporal/idade (IMC/I). Para a classificação do estado nutricional foram adotados três critérios de pontos de corte segundo a curva da população de referência: NCHS/CDC, WHO – World Health Organization - e o adotado pelo Ministério da Saúde do Brasil. Para análise transversal, os escolares foram agrupados por idade, ano de avaliação e região. Já no estudo longitudinal foram agrupados por idade, que coincide com o ano... / The nutritional status of the pediatric population is a relevant indicator of the health and quality of life of the population. However, more longitudinal studies are needed to assess the nutritional status of a particular population group over time to improve the reliability of the results. Therefore, the objective of this study is to use four crosssectional studies and one longitudinal study to assess the nutritional status over time of first- to fourth-graders attending public elementary schools in the city of Piracicaba, SP, from 2003 to 2006. A total of 16068 assessments of 9683 schoolchildren of 12 schools located in the five administrative regions of Piracicaba were made during this period, always in the second semester of each year. These groups of schoolchildren assessed on a yearly basis were called cross-sectional groups. Another group of schoolchildren (n=347) was followed from first to fourth grades during the same period the cross-sectional studies were done. They were called longitudinal group. The following data were collected: name, gender, birth date, grade, class, weight and height. The data were processed by the software Epi-info using the NCHS/CDC - National Center for Health Statistics / Centers for Disease Control and Prevention - 2000 population as reference and expressed as z-scores (Z) and percentiles (P) of the indicators height-for-age (H/A), weight-for-age (W/A), and body mass index-forage (BMI/A). The nutritional status was classified according to the cutoff points given by the NCHS/CDC, World Health Organization (WHO) and that used by the Brazilian Ministry of Health. The schoolchildren were grouped by age, year of assessment and region for the cross-sectional assessment and grouped by age (which coincides with the year of assessment) for the longitudinal assessment. Changes in the nutritional status of these schoolchildren were characterized by reducing... (Complete abstract click electronic access below)

No description available.

The objective of this study was to further determine the distribution of selenoprotein W (SeW) in tissues from rats and sheep fed different selenium levels and to search for the possible functions of this protein. In the rat study a total of 28 rat tissues were examined and SeW was found in all of the tissues except for liver, thyroid, pancreas, pituitary and eyes regardless of the level of Se fed. SeW was not detected in heart, lungs, prostate, esophagus, small intestine, tongue, skin diaphragm and skeletal muscle from selenium deficient rats, but was present in these tissues when the two higher levels of selenium (0.1 and 4.0 mg/kg) were fed. SeW has the highest expression in muscle, brain, testis and spleen when selenium is adequate. Interestingly, selenium deficiency resulted in undetectable SeW levels in heart and muscle from deficient sheep and rats, but the content in brain was unaffected by selenium status. Second generation selenium depleted and repleted rats indicated that the expression of SeW in cortex and cerebellum was not significantly affected by selenium, but selenium increased its levels in thalamus. Cortex had the highest SeW expression among the three parts of the rat brain. SeW levels in muscle, spleen, skin and testis were undetectable in weanling rats, but became detectable after 6 weeks of selenium repletion. Studies with various brain cell cultures indicated that Se appears to be metabolized differently by different brain cell types. As demonstrated in neuroblastoma and glial cells, glutathione peroxidase (GPX) activity decreased at a faster rate than SeW with neuroblastoma cells whereas SeW decreased at a faster rate than GPX activity in glial cells when selenium was removed from the media. Since other work showed that glutathione was bound to SeW, it was speculated that it has antioxidant function similar to other selenoproteins. SeW overexpressed and underexpressed cell lines were established by DNA recombinant techniques. There was a greater survival rate of overexpressed cells when incubated with 2,2'-Azobis (2-amidinopropane) dihydrochloride (AAPH) than control cells, suggesting SeW possibly has an antioxidant function. / Graduation date: 1999

Thesis (Ph. D.)--University of Missouri-Columbia, 2001. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 2001. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 2001. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 2001. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.

Thesis (M.S.)--University of Missouri-Columbia, 2003. / RGL after WOC in title is in superscript. Typescript. Includes bibliographical references. Also available on the Internet.

Thesis (M.S.)--University of Missouri-Columbia, 2003. / RGL after WOC in title is in superscript. Typescript. Includes bibliographical references. Also available on the Internet.

published_or_final_version / Medical Sciences / Master / Master of Medical Sciences