This thesis aims at analyzing the impact of water on economic growth and economic development. We explore different topics that are directly linked to the availability of water, which directly influence economic growth and development. The thesis consists of four studies. The first study models the effect of water utilization and water pollution on economic growth. The second study is based upon reflections on the fixed effects model and makes the distinction between the impact of the mean of a variable X and deviations from that mean on another variable Y. To date it has tended to be assumed that these impacts are the same; we argue that this is not always the case that countries can to an extent adjust to a specific water environment. However having adjusted they face problems when the water environment deviates from the mean. In the third study we explore the effect of different socio economic factors such as labour productivity, agricultural inputs, population density, water resources per land, and variables such as the trade regime, on water withdrawal for the agricultural and non-agricultural sectors. A specific focus is on the interactions between these two sectors. This study is new in its content and its theme of the work. We argue that many global trends will put increasing pressures on agricultural and non-agricultural water use. But there is also potential for increased efficiency in this use. The fourth study tries to fill the gap in the literature that deals with development aid for water and sanitation. We explore the impact of aid and aid volatility on safe access to water and sanitation, using a newly available OECD/DAC data base. Specifically, we analyse both the recipient countries and the donors to determine the role of aid in affecting safe access to water and sanitation.

Imprinted genes are a subset of loci, positioned on autosomes and the X-chromosome, which are expressed monoallelically in a parent-of-origin specific manner. The influence of such genes on the regulation of embryonic growth and postnatal energy homeostasis is well established. The parental conflict hypothesis predicts that, in utero, paternally-expressed genes will promote maternal resource acquisition and thus growth, whereas maternally-expressed genes will oppose this action, restricting resource investment in a single brood in the interests of the lifetime reproductive success of the mother. Grb10 is an imprinted gene which encodes the cytoplasmic adaptor protein Growth factor receptor bound protein 10. In the majority of tissues, Grb10 is expressed from the maternally-derived chromosome. Consistent with conflict theory, transgenic mice inheriting a disrupted Grb10 allele through the maternal line (Grb10Δ2-4m/+) exhibit embryonic overgrowth, although the mechanisms and signalling pathways responsible for this effect are unclear. Grb10Δ2-4m/+ mice also demonstrate enhanced insulin signalling and improved whole body glucose clearance, consistent with the established role of imprinted genes in the regulation of postnatal metabolism. An integrated LacZ gene-trap in the Grb10Δ2-4 allele failed to fully recapitulate endogenous Grb10 expression, notably within the central nervous system. To address this issue, a second transgenic mouse line, Grb10KO, was created. This allele produced strong LacZ reporter expression in the central nervous system, but only when transmitted through the paternal line (Grb10KO+/p), establishing Grb10 as the only known imprinted gene with a reciprocal imprinting profile between the central nervous system and peripheral tissues. Grb10KO+/p mice exhibit a social dominance phenotype, suggesting distinct roles for maternally- and paternally-expressed Grb10, consistent with their respective sites of expression. The current study characterised the Grb10KO allele at the genetic level, and in doing so, revealed a phenotypic difference between Grb10KOm/p and Grb10Δ2-4m/p mice for which a possible explanation was provided. Importantly, with this knowledge, the current study elucidated the genetic and molecular basis for inconsistencies in reporter expression between the two transgenic lines, identifying a novel tissue-specific enhancer element at the locus. In addition to the central nervous system, this enhancer appeared to be active in the mammary epithelium, identifying a novel site of Grb10 expression, which was pregnancy-dependent and specifically from the maternally-inherited chromosome. Characterisation of the functional significance of expression in this tissue revealed that maternally-expressed Grb10 mediates a supply/demand system between lactating mother and suckling pup, acting as a supply promoter and demand suppressor. This role is inconsistent with conflict theory, but suggests the maintenance of the Grb10 imprint in the mammary epithelium might be associated with improved coadaptiveness between mother and offspring. Intriguingly, in utero, Grb10 is both a demand and supply suppressor. When considered together, these findings suggest a wider role for maternally-expressed Grb10 in the homeostatic control of growth and achievement of optimal fitness.

Thisbe (Ths) and Pyramus (Pyr) are the ligands for the Fibroblast-Growth-Factor (FGF)receptor Heartless (Htl), which is expressed in all mesodermal cells during gastrulation. To understand how these two FGFs orchestrate mesoderm spreading in gastrulation and mesoderm differentiation during organogenesis, loss and gain of function studies were performed. In an approach of functional analysis, a single mutant allele of ths was generated, ths759, for comparison of the single mutant conditions of ths and the null mesodermal cells to migrate and differentiate in a precise pattern.

Thesis (M. Phil.)--University of Hong Kong, 1973.

No description available.

The present study challenges the negative and static stance of the recent literature on Uttar Pradesh, the most populous state of India, and espouses a balanced and moderate approach. The existing literature focuses only on human development and ignores the underlying social, political and economic changes taking place in the state. It ignores the decline in credit to the state. The present study synthesises and amalgamates various streams of literature on the state to fill the gap. It uses bank credit and its role in UP’s economic development as a tool to explore the changes and structural and regional shifts in the state. It examines bank credit to various regions, districts, occupations, rural and urban populations, large and small borrowers and gender in UP. This study explores credit in a multi-dimensional framework as a route to growth, development, inequality, globalisation, urbanisation, and empowerment. The study further explores the relationship between bank credit and the state’s human development. As a critique of the existing literature, the study examines whether UP is really lagging behind other states of India. Through a twin indicator approach, broadly grouped into income and non-income, the study shows that the state does lag on income front. The non-income indicators analysis, however, shows that a number of other states including high-income states are lagging. The study eschews the watertight categorisation of east and west UP as pursued in the existing literature, and adopts a broader regional classification. This showed that, although gradual, change has occurred in UP. The overall findings of the study suggest that structural and non-structural constraints characterise the development of the state. The multiple roles of credit have generated growth, helped in poverty reduction, but also influenced regional inequality and rural-urban inequalities, and widened the gap between small and large borrowers in the state. The empowerment of women through credit from commercial banks remains a distant goal as women receive less than 20 per cent of the total credit. Another significant finding of the study is that the income and non-income factors are strongly correlated, for instance, the strong negative relationship between income and the Human Poverty Index. The study, therefore, underlines the need for increased economic growth to achieve better economic and human development outcomes.

The present study challenges the negative and static stance of the recent literature on Uttar Pradesh, the most populous state of India, and espouses a balanced and moderate approach. The existing literature focuses only on human development and ignores the underlying social, political and economic changes taking place in the state. It ignores the decline in credit to the state. The present study synthesises and amalgamates various streams of literature on the state to fill the gap. It uses bank credit and its role in UP’s economic development as a tool to explore the changes and structural and regional shifts in the state. It examines bank credit to various regions, districts, occupations, rural and urban populations, large and small borrowers and gender in UP. This study explores credit in a multi-dimensional framework as a route to growth, development, inequality, globalisation, urbanisation, and empowerment. The study further explores the relationship between bank credit and the state’s human development. As a critique of the existing literature, the study examines whether UP is really lagging behind other states of India. Through a twin indicator approach, broadly grouped into income and non-income, the study shows that the state does lag on income front. The non-income indicators analysis, however, shows that a number of other states including high-income states are lagging. The study eschews the watertight categorisation of east and west UP as pursued in the existing literature, and adopts a broader regional classification. This showed that, although gradual, change has occurred in UP. The overall findings of the study suggest that structural and non-structural constraints characterise the development of the state. The multiple roles of credit have generated growth, helped in poverty reduction, but also influenced regional inequality and rural-urban inequalities, and widened the gap between small and large borrowers in the state. The empowerment of women through credit from commercial banks remains a distant goal as women receive less than 20 per cent of the total credit. Another significant finding of the study is that the income and non-income factors are strongly correlated, for instance, the strong negative relationship between income and the Human Poverty Index. The study, therefore, underlines the need for increased economic growth to achieve better economic and human development outcomes.

The present study challenges the negative and static stance of the recent literature on Uttar Pradesh, the most populous state of India, and espouses a balanced and moderate approach. The existing literature focuses only on human development and ignores the underlying social, political and economic changes taking place in the state. It ignores the decline in credit to the state. The present study synthesises and amalgamates various streams of literature on the state to fill the gap. It uses bank credit and its role in UP’s economic development as a tool to explore the changes and structural and regional shifts in the state. It examines bank credit to various regions, districts, occupations, rural and urban populations, large and small borrowers and gender in UP. This study explores credit in a multi-dimensional framework as a route to growth, development, inequality, globalisation, urbanisation, and empowerment. The study further explores the relationship between bank credit and the state’s human development. As a critique of the existing literature, the study examines whether UP is really lagging behind other states of India. Through a twin indicator approach, broadly grouped into income and non-income, the study shows that the state does lag on income front. The non-income indicators analysis, however, shows that a number of other states including high-income states are lagging. The study eschews the watertight categorisation of east and west UP as pursued in the existing literature, and adopts a broader regional classification. This showed that, although gradual, change has occurred in UP. The overall findings of the study suggest that structural and non-structural constraints characterise the development of the state. The multiple roles of credit have generated growth, helped in poverty reduction, but also influenced regional inequality and rural-urban inequalities, and widened the gap between small and large borrowers in the state. The empowerment of women through credit from commercial banks remains a distant goal as women receive less than 20 per cent of the total credit. Another significant finding of the study is that the income and non-income factors are strongly correlated, for instance, the strong negative relationship between income and the Human Poverty Index. The study, therefore, underlines the need for increased economic growth to achieve better economic and human development outcomes.

The present study challenges the negative and static stance of the recent literature on Uttar Pradesh, the most populous state of India, and espouses a balanced and moderate approach. The existing literature focuses only on human development and ignores the underlying social, political and economic changes taking place in the state. It ignores the decline in credit to the state. The present study synthesises and amalgamates various streams of literature on the state to fill the gap. It uses bank credit and its role in UP’s economic development as a tool to explore the changes and structural and regional shifts in the state. It examines bank credit to various regions, districts, occupations, rural and urban populations, large and small borrowers and gender in UP. This study explores credit in a multi-dimensional framework as a route to growth, development, inequality, globalisation, urbanisation, and empowerment. The study further explores the relationship between bank credit and the state’s human development. As a critique of the existing literature, the study examines whether UP is really lagging behind other states of India. Through a twin indicator approach, broadly grouped into income and non-income, the study shows that the state does lag on income front. The non-income indicators analysis, however, shows that a number of other states including high-income states are lagging. The study eschews the watertight categorisation of east and west UP as pursued in the existing literature, and adopts a broader regional classification. This showed that, although gradual, change has occurred in UP. The overall findings of the study suggest that structural and non-structural constraints characterise the development of the state. The multiple roles of credit have generated growth, helped in poverty reduction, but also influenced regional inequality and rural-urban inequalities, and widened the gap between small and large borrowers in the state. The empowerment of women through credit from commercial banks remains a distant goal as women receive less than 20 per cent of the total credit. Another significant finding of the study is that the income and non-income factors are strongly correlated, for instance, the strong negative relationship between income and the Human Poverty Index. The study, therefore, underlines the need for increased economic growth to achieve better economic and human development outcomes.

Originally presented as the author's thesis (doctoral)--Helsinki School of Economics, 2004. / Includes bibliographical references (p. 71-76). Also available online.