• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 5
  • Tagged with
  • 5
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The role of regulatory B cells in the development of autoimmune diabetes in NOD mice

Liu, Yang, 劉洋 January 2013 (has links)
Interleukin (IL)-10-secreting regulatory Bcells(B10) are acknowledged to play important roles in balancing cellular immunity and fighting against autoimmune diseases. Since the early discovery of the potential of B cells in suppressing autoimmunity by secreting IL-10 in a murine model of experimental autoimmune encephalomyelitis(EAE),accumulating evidences have revealed the existence and regulatory function of B10 cells in the progression of several autoimmune diseases including multiple sclerosis (MS), lupus and autoimmune arthritis, suggesting potential values of therapeutic intervention. Autoimmune diabetes is an autoimmune disease in animal models characterized by progressive insulitis and mass destruction of βcells in pancreatic islets. However, the role of Bregsin the development of this disease remains largely unclear. To explore whether Bregs possess a regulatory function in suppressing diabetes, B10 cells were generated from B-cell activation factor (BAFF)-stimulated B cells of Non-obese diabetic (NOD)mice. Notably, NOD mice receiving B10 transfer exhibited delayed diabetes onset and substantially reduced incidence, suggesting some therapeutic effect against autoimmune diabetes. As an important contributor to inflammation and autoimmune disorders, the pathogenic function of IL-17 producing CD4+cells (Th17) in autoimmune diabetes has been increasingly identified, which attracts me to investigate whether B10 cells can contribute to amelioration of autoimmune diabetes via suppressing Th17 cells. During the development of autoimmune diabetes in NOD mice, both B10 and Th17 significantly increased at prediabetic stage and rapidly declined after disease onset. Upon adoptive transfer of B10 cells into prediabetic NOD mice, Th17 cells in pancreatic lymph nodes and pancreas were profoundly reduced. To verify whether B10 cells can directly inhibit Th17 generation in vitro, CFSE-dilution assay combined to Th17 polarization assay was performed. Results indicated that B10 cells suppress Th17 polarization in an IL-10 independent manner, but inhibit Th17 proliferation in an partially IL-10 dependent way. Finally I transferred B10 together with naive CD4+T cells reactive to islets into lymphopenic NOD-SCID mice and detected substantially reduced Th17 frequencies in pancreatic lymph nodes and pancreas, suggesting a potential way of developing new therapeutic strategies in treating Type 1 diabetes in humans. / published_or_final_version / Pathology / Master / Master of Philosophy
2

Structural and functional characterization of human APPL2, a novel adaptor protein involved in insulin signaling

Chen, Bin, 陈斌 January 2010 (has links)
published_or_final_version / Medicine / Master / Master of Philosophy
3

APPL1 and APPL2: a pair of adaptor proteins as "yin-and-yang" regulators of insulin signaling in skeletalmuscle

Zhu, Weidong, 朱伟东 January 2011 (has links)
published_or_final_version / Medicine / Doctoral / Doctor of Philosophy
4

APPL1 as a novel signaling mediator of adiponectin and insulin: molecular mechanisms and physiologicalimplications

Cheng, King-yip, 鄭競業 January 2009 (has links)
published_or_final_version / Medicine / Doctoral / Doctor of Philosophy
5

Molecular pathways underlying beta-cell loss in vitro models of type 2 diabetes mellitus

Kharroubi, Ilham January 2006 (has links)
Doctorat en Sciences médicales / info:eu-repo/semantics/nonPublished

Page generated in 0.0816 seconds