Diaper dermatitis, an acute inflammatory reaction of the skin, is one of the most common forms of dermatitis among neonatal and pediatric patients. The problem addressed in this quality improvement project was the absence of an evidence-based practice (EBP) guideline for perineal care which resulted in 4 unexpected cases of diaper dermatitis per 100 hospital days at a non free standing children's hospital. Framed within Rosswurm and Larrabee's model for EBP, the purpose of this project was to develop an educational initiative encompassing an EBP guideline for perineal care, an educational curriculum plan for staff members, and a Power Point presentation to leadership on the educational initiative. A master's prepared pediatric nurse educator served as content expert to evaluate the educational curriculum plan using a dichotomous scale (not met = 1/met = 2) format for the 8 objectives. Each of the 8 items was scored a 2, meaning all objectives were covered in the curriculum. The expert recommended that the methods and procedures used should be placed in the employee orientation process. The educational initiative was presented to the leadership team (n = 11) who evaluated the project using a Likert-type scale ranging from 1 (strongly disagree) to 5 (strongly agree). An average score of 5 was given, revealing that the objectives of the presentation were met. The leadership team recommended that the project be implemented. Positive social change may result from this DNP project by facilitating neonatal/pediatric skin integrity through evidence-based nursing care thus promoting patient well-being and prevention of hospital acquired infections.