In search of mutable tectonics is a research investigation linking principles found in natural systems, investigated by various fields in biology, physics, and mathematics, in the creation of a design methodology in Architecture. Specifically the report looks into natural system with packing and stacking strategies like bone formation, foam or soap bubbles, and sphere packing. Rules and physical observations of the natural are carried forward in the development of a topological language, through digital investigations, which define relationships between variations in spatial configurations and structural members. What we hope to achieve here is that by studying natural systems already realized in the natural world a more adaptive system of design between form, structure and space is immediately established; resulting in the discovery of emergent spaces which intrinsically conveys an emergent structural system and vise versa. The outcome is the creation of an adaptive networked process in the design formulation in Architecture.

This master’s thesis is focused on automating the process of differential leukocyte count in peripherial blood using image processing. It deals with the design of the processing of digital images - from scanning and image preprocessing, segmentation nucleus and cytoplasm, feature selection and classifier, including testing on a set of images that were scanned in the context of this work. This work introduces used segmentation methods and classification procedures which separate nucleus and the cytoplasm of leukocytes. A statistical analysis is performed on the basis of these structures. Following adequate statistical parameters, a set of features has been chosen. This data then go through a classification process realized by three artificial neural networks. Overall were classified 5 types of leukocytes: neutropfiles, lymphocytes, monocytes, eosinophiles and basophiles. The sensitivity and specificity of the classification made for 4 out of 5 leukocyte types (neutropfiles, lymphocytes, monocytes, eosinophiles) is higher than 90 %. Sensitivity of classiffication basophiles was evaluated at 75 % and specificity at 67 %. The total ability of classification has been tested on 111 leukocytes and was approximately 91% successful. All algorithms were created in the MATLAB program.