Global ETD Search

1	A study of the effects of dehydration on blood urea nitrogen in the canine Hegde, Vonthibettu Ravivarma January 2011 (has links) Digitized by Kansas State University Libraries Body fluids Dogs--Physiology
2	PHENCYCLIDINE DISPOSITION IN DOGS (PCP). WOODWORTH, JAMES READ. January 1983 (has links) Phencyclidine (PCP) has become a major drug of abuse in recent years, and treatment of PCP overdose thus becomes a major concern. This dissertation was designed to examine the pharmacokinetics of PCP in dogs and to provide a rational basis for overdose treatment. One method of treating toxicity was also tested. Before any animal studies could begin, however, analytical procedures for PCP and its metabolites had to be developed. Three gas chromatographic procedures capable of analyzing PCP, two monohydroxymetabolites (PCHP and PPC), and a pentanoic acid metabolite (PCAPA) were developed. Each assay was validated for accuracy and precision. The analytical methods for the metabolites of PCP were up to 50 times more sensitive than others previously reported in the literature. The analytical method for PCP, PCHP and PPC was also able to separate the cis and trans forms of PPC. Animal studies were performed to determine the pharmacokinetic behavior of PCP in dogs. From these experiments, PCP was determined to have a very high clearance (Cls) value approaching the upper limits of hepatic blood flow. PCP has a very large volume of distribution (V) and relatively short half-life (t(, 1/2)). The clearance of PCP was mainly due to metabolism and not to excretion of the unchanged drug. Radioactivity studies showed total recovery ranging between 65 and 80% of the dose administered. PCP was primarily metabolized to PCAPA, PCHP, and PPC. PCHP and PPC were very quickly conjugated. Bioavailability ranged between 15 and 50%. Oral clearance, an estimate of intrinsic clearance, was very large. Pharmacokinetic parameters of PPC and PCHP were similar to each other and comparable to PCP. The administration of activated charcoal increased the clearance of PCP but this increase was not statistically significant from controls. Dogs -- Physiology. Phencyclidine -- Metabolism.
3	Placentation in the dog Romanucci, Demostene. January 1951 (has links) Call number: LD2668 .T4 1951 R66 / Master of Science Dogs--Physiology. Masters theses
4	The follicular cycle in the dog Poling, Kit Elizabeth January 2010 (has links) Digitized by Kansas Correctional Industries Ovaries Dogs--Physiology
5	Studies on the haemodynamics of adrenaline pulmonary oedema in dogs 鄭寶剛, Cheng, Po-kong, Constant. January 1973 (has links) published_or_final_version / Physiology / Doctoral / Doctor of Philosophy Pulmonary edema. Dogs - Physiology.
6	Transaminase activity in serum, urine, and cerebrospinal fluid of normal and diseased dogs Hibbs, Clair M. January 1962 (has links) Call number: LD2668 .T4 1962 H53 Enzymes. Dogs--Physiology. Masters theses
7	Studies on gut macrophages, blood monocytes and alveolar macrophages in the dog Shaw, Susan Elizabeth January 2011 (has links) Typescript (photocopy). / Digitized by Kansas Correctional Industries Macrophages Dogs--Physiology Veterinary immunology
8	Investigation of acetylsalicylic acid bioavailability and its effect on prostaglandin-F₂α in dogs Owonubi, Mary O January 2011 (has links) Digitized by Kansas Correctional Industries Aspirin Dogs--Physiology Medicine, Biochemic
9	An epidemiologic study of canine multiple primary neoplasia / Bender, Alan Paul January 1980 (has links) No description available. Biology Dogs--Physiology Multiple tumors
10	Anatomical, ultrastructural and biochemical features of the canine uterine tube (oviduct) / Del Campo, Carlos Humberto January 1980 (has links) No description available. Biology Fallopian tubes Dogs--Physiology

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