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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Enzyme profiles of control and sulfuric acid aerosol stressed alveolar macrophages

Elvick, Allen LeRoy, 1942- January 1978 (has links)
No description available.

Determination of a catalytic mechanism for the enzymatic activity of macrophage migration inhibitory factor /

Stamps, Stacy Leanne, January 1998 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 127-133). Available also in a digital version from Dissertation Abstracts.

Evaluation of immunomodulatory chemicals alteration of macrophage effector function in vitro and in vivo /

Tam, Patricia E. January 1985 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1985. / Typescript. Vita. Description based on print version record. Includes bibliographical references (leaves 81-96).

The effect of the normal flora on macrophage-mediated direct and antibody-dependent tumor cytotoxicity

Johnson, William Joseph. January 1980 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1980. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Analyse de la mobilité des macrophages pour le développement d'un biocapteur atmosphérique

Laval-Gilly, Philippe. Ferard, Jean-François January 2000 (has links) (PDF)
Thèse de doctorat : Toxicologie de l'environnement : Metz : 2000. / Thèse : 2000METZ052S. Bibliogr. p. 142-168.


Vela, Elizabeth Edith. January 1983 (has links)
No description available.

Role of monocytes in the pathogenesis of HIV-1 infection

Verani Borgucci, Alessia January 2000 (has links)
No description available.

Glomerular self-defence : a role of mesangial cell-derived transforming growth factor- #beta#

Süto, Tamas Sandor January 1999 (has links)
No description available.

Studies with SlyA, a transcription regulator and virulence determinant of Salmonella typhimurium

Stapleton, Melanie January 2003 (has links)
No description available.

Regulating human Th17 polarisation by activated macrophages

Kluge, Christina January 2012 (has links)
Inflammatory diseases such as autoimmune and atopic diseases are a common problem worldwide. Although there have been substantial advances in medical therapies, current treatments are not able to cure these conditions. In order to develop more specific, individually targeted and efficient treatments, a better understanding of the cells, mediators and mechanisms that lead to pathology are necessary. Macrophages and T cells are major players in the human immune system. Despite the abundance of macrophages at inflammatory sites and their secretion of T cell polarising cytokines, their roles as antigen presenting cells has been overlooked until now. This PhD project aimed to determine, firstly, the contribution of differentially activated human macrophages in the regulation of adaptive immune responses in inflammation with the main focus on the pro‐inflammatory T cell subset Th17, secondly, how macrophage functions could be modified to alter T cell polarisation and thirdly, how novel alternative mechanisms using electric fields can alter T cell responses. I demonstrate for the first time that macrophages can efficiently induce T cell polarisation and Th17 differentiation in response to recall and primary antigens and that the specific macrophage activation state is essential to drive Th17 responses. This suggests that macrophages are an important stimulus contributing to pathogenic T cell responses in human inflammatory diseases. Importantly, both memory and naïve T cells gave rise to Th17 cells following culture with antigen‐loaded activated macrophages, where non‐specific effects of mitogenic activation were avoided. Targeting human macrophage signalling pathways through SOCS3, reduced their pro‐inflammatory potential and Th17 polarising ability, pointing to SOCS3 as an effective therapeutic target. As an alternative approach, I demonstrate here that small electric fields of physiological strength strongly influence immune responses and significantly dampen Th17 differentiation. This suggests that EFs have the potential to facilitate healing processes or support conventional therapies for inflammatory diseases. Overall, these data present a strong basis for the development novel treatment possibilities for inflammatory diseases that are distinct from the currently used conventional therapies.

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