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Considering the infection and second trauma caused by dressing changes, development of antibacterial and low-adherent wound dressings is urgently needed. Silver ion is a widely used antimicrobial agent, but its cytotoxicity remains a problem. In this study, low-adherent PAM (polyacrylamide) hydrogel incorporated with less toxic AgNP (silver nanoparticle), was immobilized onto PET (poly(ethylene terephthalate)) substrates by an IPN (interpenetrating polymer network) method. The modified PET is effectively antibacterial and the surface is significantly less adherent than untreated PET. However, silver-resistant bacteria become a potential problem. Thus, ionic 5,5-dimethylhydantoin (DMH) analogues containing either a quaternary ammonium moiety or a phosphonate functional group were designed and synthesized. The DMH analogues were converted to antibacterial N-chloramine counterparts through chlorination to serve as potential alternatives to AgNP. The N-chloramine with a structural cation exhibited distinctly enhanced antibacterial functions both in solution and after immobilization on fabrics.

This thesis describes the author's investigations into the design of a burn dressing; the use and mode of action of silicone gel when applied to hypertrophic scars, and its use as a burn dressing. This research was carried out at the Bioengineering Unit, Strathclyde University in conjunction with the Burns Units at Glasgow Royal Infirmary and the Royal Hospital for Sick Children, Glasgow, and the Dow Corning Corporation. The Introduction provides a background to the history of burn dressings and hypertrophic scarrinfg The need to define the "ideal" burn dressing is emphasised, and the thesis objectives are stated. Chapters 2 and 4 provide a background to the study by describing the anatomy and physiology of skin, wound healing, burns, hypertrophic scarring and burn dressings. The limitations of presently available burn dressings is reviewed in Chapter 5. Quantitative, critical criteria, useful for defining the "ideal" burn dressing, are presented in the same chapter. Chapter 6 is a literature review on the chemistry and medical applications of silicones. The treatment of hypertrophic scars with silicone gel is discussed in Chapter 7. The mode of action of the material has been examined and a possible explanation is presented. Chapter 8 explores the possibility of using silicone gel as a burn dressing by examining its relevant properties and the application to burn wounds. The results of the investigation are discussed in Chapter 9. Silicone gel has been found to be a very effective treatment for hypertrophic scars. However, more research is required to fully discover its potential as a burn dressing, and to completely define the "ideal" burn dressing quantitatively.

Considering the infection and second trauma caused by dressing changes, development of antibacterial and low-adherent wound dressings is urgently needed. Silver ion is a widely used antimicrobial agent, but its cytotoxicity remains a problem. In this study, low-adherent PAM (polyacrylamide) hydrogel incorporated with less toxic AgNP (silver nanoparticle), was immobilized onto PET (poly(ethylene terephthalate)) substrates by an IPN (interpenetrating polymer network) method. The modified PET is effectively antibacterial and the surface is significantly less adherent than untreated PET. However, silver-resistant bacteria become a potential problem. Thus, ionic 5,5-dimethylhydantoin (DMH) analogues containing either a quaternary ammonium moiety or a phosphonate functional group were designed and synthesized. The DMH analogues were converted to antibacterial N-chloramine counterparts through chlorination to serve as potential alternatives to AgNP. The N-chloramine with a structural cation exhibited distinctly enhanced antibacterial functions both in solution and after immobilization on fabrics.

Thesis (MEng)--University of South Australia, 1996

Thesis (B.S.)--University of Missouri, School of Mines and Metallurgy, 1899. / The entire thesis text is included in file. Typescript. Illustrated by author. Edwin T. Perkins determined to be Edwin Thompson Perkins from "Thirty-Third Annual Catalogue of the School of Mines and Metallurgy". Title from title screen of thesis/dissertation PDF file (viewed November 13, 2008)

Thesis (B.S.)--University of Missouri, School of Mines and Metallurgy, 1914. / The entire thesis text is included in file. Typescript. Illustrated by author. Title from title screen of thesis/dissertation PDF file (viewed April 29, 2009)