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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Liposomes as drug delivery systems

Allen, Rosamund Elizabeth January 1989 (has links)
No description available.
12

Human psychopharmacology of second generation antidepressants

Fairweather, Diane Bree January 1996 (has links)
No description available.
13

The effect of bioreducible cytotoxic drugs upon the SOS response of Escherichia coli

Widdick, David Andrew January 1991 (has links)
The DNA damaging activity of RSU 1069 and seven of its analogues (RSU 1131, RSU 1164, RSU 1150, RB 7040, RSU 1172, RSU 1137 and RSU 1170) plus misonidazole and CB 1954 were investigated using the SOS-Chromotest The SOS-Chromotest is a genotoxicity assay that monitors the induction of the SOS response, which is induced in response to DNA damage. The strains used were PQ37, which possesses a uvrA mutation and is deficient in UvrA excinuclease activity, and PQ35, which is uvr and UvrABC excinuclease conpetent. These strains were exposed to the compounds being investigated under both oxic and hypoxic conditions. The results showed that RSU 1069 and some of its analogues were more active than misonidazole under both oxic and hypoxic conditions. This increase was due to their aziridine side-chains. With the exception of RSU 1137 and RSU 1170 all of the compounds showed altered SOS induction activities between oxic and hypoxic conditions. This alteration was shown to correlate with increased reduction of their nitro-groups under hypoxia. There was a difference in the hypoxic activities of RSU 1069 and some of its analogues between the uvrA-strain and the uvr -strain. With the uvrA-strain RSU 1069 showed decrease activity under hypoxia compared to oxia, whereas, the converse applied with the uvr -strain. This was interpreted to mean that RSU 1069 caused some damage that required an active UvrABC excinuclease to produce an SOS response. It has been proposed that this damage takes the form of DNA crosslinks. RSU 1137 showed insignificant SOS induction and this was demonstrated to be due to its nitro-group not being reduced. It was suggested that the ring opened aziridine side chain of RSU 1137 in some way inhibited its bioreduction. The order of activity of the drugs for SOS induction activities did not correlate with that for their toxicities. This indicated that DNA lesions other than, or in addition to, those responsible for cytotoxicity induced the SOS response. The DNA damaging activity and mutagenicity of RSU 1069 was also investigated using Ml3 phage rfDNA. Radiation reduced RSU 1069 was shown to produce some relatively long lived product that was more active towards DNA than unreduced RSU 1069, as judged by phage survival. Unreduced RSU 1069 was shown to be non-mutagenic, producing mutation rates under 1.5 times background level. The effect of strict hypoxic conditions upon the SOS response was investigated using the SOS-Chromotest with the uvrA tester strain. The results showed that the SOS response was induced under strictly anaerobic conditions in E. coli but that the response was altered compared to that obtained aerobically. The nature of the alteration was not determined as six different compounds, with five different modes of action, were used as SOS-inducers and all showed different types of response under hypoxic conditions.
14

An investigation of some of the mechanisms of action of angiotensin converting enzyme inhibitors

Kondowe, Greeves Burton Chianira January 1986 (has links)
No description available.
15

Cardiovascular control by central beta-adrenoceptors in the rat

Mchowat, Jane January 1987 (has links)
No description available.
16

Effect of antidepressant treatment on social behaviour and circadian rhythms of locomotor activity in the rat

Mitchell, P. J. January 1989 (has links)
No description available.
17

Studies of the cardiovascular effects of inotropic agents and vasodilators on the pulmonary and systemic circulation in man

Wathen, Christopher George January 1988 (has links)
No description available.
18

The development and evaluation of a hydrogel drug delivery system for dithranol

Priprem, Aroonsri January 1991 (has links)
No description available.
19

Hormonal modulation of drug-induced DNA damage and repair in human tumour cells

Epstein, Richard John January 1988 (has links)
No description available.
20

Pharmacokinetics and antihypertensive effect of the serotonin antagonist ketanserin

Waller, Patrick Charles January 1988 (has links)
No description available.

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