Background: In the past few decades, with increasing advances in neonatology, more preterm infants have survived. In developed countries, about 12% - 42% of surviving very low birth weight (VLBW) infants developed bronchopulmonary dysplasia (BPD). This chronic lung disease is a severe health burden for both the family and public health resources, and presents several challenges to clinicians and public health practitioners. In the Guangdong province of China, there is no reliable data and research on BPD. Objective: This study aimed to assess the incidence and the epidemiological profile of BPD, as well as possible risk factors of BPD in a Guangdong provincial transportation network for critically ill neonates. Methods: This was a retrospective cohort study. Data on all VLBW infants (birth weight ≤ 1500g) who were admitted to the neonatal intensive care unit (NICU) of Guangdong Provincial Women and Children’s Hospital (GDWCH) from Jan. 1st 2013 to Dec.31st 2013 were collected from medical records of GDWCH (n=168). The incidence rate of BPD was estimated, and associations with demographic characteristics, maternal characteristics and factors related to clinical practice were described and assessed by univariate analysis and multivariate regression analysis with stepwise (backward) method. At last, a logistic regression model was adopted to predict the potential risk factors for BPD. Results: The incidence rate of BPD in VLBW infants in this transportation network for critically ill infants during the study period was 44.6 cases per 100 person-years [95% confidence interval (CI) 40.8 - 48.4 cases per 100 person-years] based on the National Institute of Child Health and Human Development’s (NICHD) definition of BPD. Overall, infants with gestational age (GA) < 30 weeks were more likely to develop BPD [adjusted odds ratio (OR) 4.64; 95% CI 1.97, 10.89], compared to the infants with GA ≥ 30 weeks. Infants diagnosed with asphyxia (adjusted OR 2.78; 95% CI 1.08, 7.18) and infants who received endotracheal tube (ETT) ventilation ≥ 1 day (adjusted OR 3.90; 95% CI 1.33, 11.39) also had higher risk of BPD. On the other hand, female infants were less likely to develop BPD than male infants (adjusted OR 0.37; 95% CI 0.16, 0.87). Predictors for the development of BPD were infants with GA < 30 weeks, male gender, asphyxia and ETT ventilation ≥ 1 day. Conclusion: The results of this study suggest that the prevention of prematurity may contribute to a decrease in the incidence of BPD. Improvement on strategies of supplemental oxygen and mechanical ventilation could potentially lower risk in preterm infants. Further study could focus on clinical practice as well as administrative implementation on neonatology, in order to improve healthcare services. / published_or_final_version / Public Health / Master / Master of Public Health

No description available.

Human tumor susceptibility gene 101, TSG101, exhibits a variety of functions including protein sorting, vesicular trafficking, and regulation of transcription, epithelial growth and differentiation. The upstream sequence of TSG101 gene shows a typical housekeeping TATA-less and Sp1 containing promoter. Our previous data indicated the essential role of TSG101 in skin keratinocyte differentiation that is under the regulation of PKC-Sp1 signaling. In this report, we investigated the correlation of TSG101 and Sp1 expression in the specimens of cervical intraepithelial neoplasia. Cervical intraepithelial neoplasia specimens used in this study were 129 paraffin blocks from 41 normal, 35 CIN I, 28 CIN II and 25 CIN III/CIS patients collected in Cancer Prevention and Screening Center at Kaohsiung from January 2005 to July 2007. The expression of TSG101 and Sp1 were analyzed by immunohistochemistry and digitally quantified by Image Pro-plus 6.1 Microimage software according to the method described by Eliane Pedra Dias et al. The quantified data were statistically analyzed using Spearman's rho coefficient and SPSS for Win, v.14 statistical software (SPSS Inc., Chicago, USA). Values were considered significantly different when the P value < 0.05. We found that TSG101 and Sp1 are expressed in cells of parabasal and intermediate layers in normal cervical epithelium, whereas their expressions in basal and superficial layers were either absence or reduced. Interestingly, the expressions of these two markers are significantly increased in more advanced progression stages (CIN II and CIN III/CIS) of cervical intraepithelial neoplastic specimens (P < 0.05). Congruous expression pattern of TSG 101 and Sp1 in normal cervical epithelium confirms the important of cellular Sp1 signaling in regulating TSG101 expression, which is essential during epithelial cell growth and differentiation. Our results also indicate upregulation of these two markers might be important for the progression of cervical intraepithelial neoplasia. Further analysis using more specimens should reveal the prognostic value of these two markers.

Thesis (M.S.)--University of Alabama at Birmingham, 2007. / Title from PDF title page (viewed Feb. 1, 2010). Includes bibliographical references (p. 19-24).

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Thesis (Ph.D.)--Tufts University, 2001. / Adviser: Shuk-mei Ho. Submitted to the Dept. of Biology. Includes bibliographical references (leaves 178-196). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 7 uppsatser.

Thesis (M.S.)--Ohio State University, 2009. / Title from first page of PDF file. Includes bibliographical references (p. 71-76).