Objectives. To identify treatment indications for symptomatic and asymptomatic Florid Cemento- Osseous Dysplasia in adult patients. To explore the relationship between clinical variables, demographics, and radiographic findings. Methods. A systematic review was conducted by an independent investigator using the electronic databases, PubMed, ProQuest, Embase, Web of Science, Dentistry and Oral Sciences Database (DOSS) and TRIP databases to identify cohort, retrospective, and cross-sectional studies on Florid Cemento-Osseous dysplasia treatment options in adults from 2001-2022. Inclusion criteria for this systematic review included: studies must be in English; open-access; published between 2001-2021. The PRISMA guidelines and Joanna Briggs Institute (JBI) Critical Appraisal checklist were used for reporting and quality assessment of each study. Results. From initial 122 studies, 11 fit the criteria and were analyzed for this systematic review. Black females were reported to have significant presentation for FCOD. Mean age of patients was 40 years old. Eight studies reported symptoms as clinical presentation of FCOD, making it the most common. Six studies reported swelling and three studies reported infection. Five studies recommended surgical treatment in symptomatic patients with disturbances around the lesions such as, presence of necrotic bone, secondary infection, or neoplasia. Treatment of asymptomatic FCOD or biopsies were contraindicated in all studies but one, while dental prophylaxis was recommended. Conclusion. For cases of Asymptomatic FCOD, dental prophylaxis and monitoring were the most common treatment options provided. According to existing literature, symptomatic FCOD may be treated through curettage, blood stimulation, or pulp vitality testing of specific areas with periapical inflammation. Continued dental prophylaxis and monitoring were the most common treatment options suggested. More research should be done using experimental and clinical trials to explore proper treatment options for symptomatic and asymptomatic FCOD to draw clear consensus. / Oral Biology

No description available.

Purpose: The specific aim of this study is to evaluate the trends in dental health care for individuals with ectodermal dysplasia. Methods: This was a cross sectional analysis of subjects recruited through the National Foundation of Ectodermal Dysplasia (NFED). From 1997 to 2000, individuals with ectodermal dysplasia or their caregiver (if the individuals were too young to selfreport) voluntarily completed questionnaires. The questionnaire consisted of 37 items consisting of demographics, ectodermal dysplasia diagnosis, access to dental care, level of dental utilization, and type of dental services received. Descriptive statistics were used in addition to ANOVA analyses to evaluate the changing trends in oral health care for individuals with ectodermal dysplasia. Results: Preliminary results indicate: 1) individuals with ectodermal dysplasia are being diagnosed earlier than in the past, 2) physicians are primary source of the initial diagnosis of ectodermal dysplasia, 3) children with ectodermal dysplasia are receiving prostheses earlier than in the past, and 4) access to care is problematic. Conclusion: Diagnosis and recognition of treatment needs are occurring at an earlier age and that an access to dental care for individuals with ectodermal dysplasia continues to be an issue.

ABSTRACT A group of 133 hips with developmental dysplasia of the hip (DDH) are reviewed in the form of a clinical audit. The aim of the study is to determine the relevance of measuring the ossific nucleus centre edge angle (ONCEA) to determine if this measurement can be used to predict the final outcome and the need for a secondary procedure at an earlier age than currently determined. The ONCEA is defined as an approximation of the lowest centre edge angle within six months of removal of the Batchelor POP, following reduction (mean age 24.1 months). It is measured earlier than the centre edge angle (CEA), which is generally used from the age of five years. The ONCEA was divided into three groups: - Reduced (>=10°) – Group A - Mild subluxation (-9° to 9°) – Group B - Severe subluxation (<=-10°) – Group C The significance of the ONCEA was confirmed using the ONCEA/AI ratio, which was also divided into three groups: - Reduced (>0.5) – Group A - Mild subluxation (0 to 0.5) – Group B - Severe subluxation (<0) – Group C Outcome was assessed radiologically by way of the Severin score: In group C there were only 1/13 hips (8%) with an excellent result, in group B there were 20/44 hips (45%) with an excellent result and in group A there were 39/76 hips (51%) with an excellent result. Using Fisher’s exact test, a statistically significant association was shown between each group and subsequent outcome (p=0.001). A significant result was also shown in a comparison of the three ONCEA groups using the McKay classification (a clinical outcome measurement). The ONCEA/AI ratio was also used to include the degree of acetabular coverage. It had similar statistically significant results as described for the above ONCEA results, thus confirming the findings. In conclusion, the ONCEA or ONCEA/AI ratio can be used at an early age (within six months following removal of POP after reduction, at a mean of 18 months of age) for two purposes: 1. To prognosticate the medium and long-term outcome of the patient. 2. To enable the clinician to determine whether a secondary procedure should be performed at an earlier age than usual. A prospective study will be necessary to confirm this.

No description available.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2009. / Härtill 3 uppsatser.

Clouston hidrotic ectodermal dysplasia (BED) is an autosomal dominant skin disorder that is characterized by nail dystrophy, hair defects and palmoplantar hyperkeratosis. This condition has been described in families of various ethnic origins but is particularly common in the French Canadian population. Using linkage analysis in eight French Canadian families segregating HED, we mapped the HED gene to the pericentromeric region of chromosome 13q with a combined two-point lod score of 8.12 at zero recombination from the marker D13S175. Haplotype analysis allowed us to define D13S143 as the telomeric flanking marker for the HED candidate region. We tested five genes that map to this region, connexin 26, connexin 46, fibroblast growth factor 9, zinc-finger ZNF198 and alpha tubulin TUBA2, for involvement in HED by PCR-SSCP analysis. No mutation specific to HED was found in any of them suggesting that they most likely are not defective in this disease. / To facilitate the identification of the HED gene, we constructed a radiation hybrid (RH) map of 48 loci surrounding the HED locus on chromosome 13q. This map integrates 3 genes (TUBA2, GJbeta2 and FGF-9) and 18 ESTs with 27 markers including 19 polymorphic loci. A major inconsistency in order involving a reversed interval of six loci was found between our RH map and a YAC contig established in the region. We used Fiber-FISH and FISH on interphase nuclei to confirm our order. To refine the localization of the HED gene, we isolated eight new chromosome 13q polymorphic (CA)n markers and used seven of them along with three others in genetic analysis of a multiethnic group of 29 HED families. We demonstrated genetic homogeneity in HED in four families of French, Spanish, African and Malaysian origins and showed evidence for a strong founder effect in families of French Canadian origin. Recombination mapping placed the HED gene in a 2.4 cM region flanked by D13S1828 proximally and D13S1830 distally. Multipoint linkage and linkage disequilibrium analyses finely mapped the HED gene at 0--0.08 cM telomeric to D13S1835. These studies will greatly facilitate the physical mapping and positional cloning of the HED gene.

Objectives: This project explores the demographic and clinical presentation of cemento-osseous dysplasia (COD), and their pathognomonic radiographic features. Methods: Demographic and clinical data were collected from the charts of 118 subjects with COD from the Oral Radiology archives. Using a systematic objective survey instrument, 3 general dentists (GP) and 3 oral radiologists (RG) reviewed 50 image sets of COD and similarly-appearing entities. Participants were asked to identify radiographic features and to make a diagnosis based on the images provided. Results: The majority of cases occurred in clinically asymptomatic females in their fifth decade. RGs identified a well-defined border, radiolucent periphery, bilateral occurrence, mixed radiolucent/radiopaque internal structure, and association with anterior and posterior teeth as key features, correctly interpreting 79.3% of COD cases. The absence of root resorption and an association with anterior and posterior teeth were the only key features that guided GPs to correctly interpret 38.7% of COD cases.

Objectives: This project explores the demographic and clinical presentation of cemento-osseous dysplasia (COD), and their pathognomonic radiographic features. Methods: Demographic and clinical data were collected from the charts of 118 subjects with COD from the Oral Radiology archives. Using a systematic objective survey instrument, 3 general dentists (GP) and 3 oral radiologists (RG) reviewed 50 image sets of COD and similarly-appearing entities. Participants were asked to identify radiographic features and to make a diagnosis based on the images provided. Results: The majority of cases occurred in clinically asymptomatic females in their fifth decade. RGs identified a well-defined border, radiolucent periphery, bilateral occurrence, mixed radiolucent/radiopaque internal structure, and association with anterior and posterior teeth as key features, correctly interpreting 79.3% of COD cases. The absence of root resorption and an association with anterior and posterior teeth were the only key features that guided GPs to correctly interpret 38.7% of COD cases.

Thesis (M.S.)--University of Michigan, 1964.