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Ip Wai-Ho Herman. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 87-90). / Abstracts in English and Chinese. / Abstract (English) --- p.ii / Abstract (Chinese) --- p.iii / Acknowledgement --- p.iv / Declaration --- p.v / Table of Content --- p.vi / List of Tables --- p.ix / List of Figures --- p.x / Chapter 1 --- INTRODUCTION --- p.1 / Chapter 1.1 --- Fourier transform ion cyclotron resonance mass spectrometry (FRICR) --- p.2 / Chapter 1.1.1 --- History of FTICR --- p.2 / Chapter 1.1.2 --- Theory of FTICR --- p.4 / Chapter 1.1.3 --- FTICR with electrospray ionization source --- p.10 / Chapter 1.2 --- Tandem mass spectrometry --- p.11 / Chapter 1.2.1 --- Introduction --- p.11 / Chapter 1.2.2 --- Collision-induced dissociation --- p.12 / Chapter 1.2.3 --- Surface-induced dissociation --- p.12 / Chapter 1.2.4 --- Photodissociation --- p.13 / Chapter 1.2.5 --- Blackbody infrared radiative dissociation (BIRD) --- p.13 / Chapter 1.3 --- Electron capture dissociation --- p.13 / Chapter 1.4 --- Recent advances in ECD experiments --- p.15 / Chapter 1.5 --- Outline the present work --- p.17 / Chapter 2. --- EXPERIMENTAL AND INSTRUMENTATION --- p.18 / Chapter 2.1 --- Instrumentation --- p.19 / Chapter 2.1.1 --- Fourier-transform ion cyclotron resonance mass spectrometer --- p.19 / Chapter 2.1.2 --- Vacuum system --- p.19 / Chapter 2.1.3 --- Electrospray ionization source --- p.23 / Chapter 2.1.4 --- Electrostatic ion focusing system --- p.26 / Chapter 2.1.5 --- Infinity cell --- p.28 / Chapter 2.1.6 --- Electron emission source --- p.29 / Chapter 2.1.7 --- Data acquisition system --- p.32 / Chapter 2.2 --- Experimental --- p.32 / Chapter 2.2.1 --- Simple acquisition pulse program --- p.32 / Chapter 2.2.2 --- ECD pulse program with/without collision cooling --- p.35 / Chapter 3. --- OPTIMIZATION OF EXPERIMENTAL PARAMETERS FOR ELECTRON CAPTURE DISSOCIATION --- p.38 / Chapter 3.1 --- Introduction --- p.39 / Chapter 3.2 --- Experimental --- p.40 / Chapter 3.2.1 --- Materials --- p.40 / Chapter 3.2.2 --- Sample preparation --- p.41 / Chapter 3.2.3 --- Instrumentation --- p.41 / Chapter 3.3 --- Results and discussion --- p.42 / Chapter 3.3.1 --- Benchmark conditions --- p.42 / Chapter 3.3.2 --- Effect of the filament heating currents (If) --- p.45 / Chapter 3.3.3 --- Effect of the average filament bias voltages (Vf) --- p.49 / Chapter 3.3.4 --- Effect of the electron irradiation time (te) --- p.53 / Chapter 3.3.5 --- Reduction of the fragment ions intensity --- p.56 / Chapter 3.3.6 --- Effect of the trapping potentials --- p.60 / Chapter 3.4 --- Conclusions --- p.62 / Chapter 4. --- ENHANCEMENT ON ELECTRON CAPTURE DISSOCIATION EFFICIENCY --- p.63 / Chapter 4.1 --- Introduction --- p.64 / Chapter 4.2 --- Experimental --- p.65 / Chapter 4.2.1 --- Materials --- p.65 / Chapter 4.2.2 --- Sample preparation --- p.65 / Chapter 4.2.3 --- Instrumentation --- p.65 / Chapter 4.3 --- Results and discussion --- p.66 / Chapter 4.3.1 --- Effect of the filament position --- p.66 / Chapter 4.3.2 --- Effect of the collision gas pressure --- p.68 / Chapter 4.3.3 --- Effect of the collision gas --- p.73 / Chapter 4.3.4 --- Effect of the electron irradiation at different pulse gas interval --- p.75 / Chapter 4.3.5 --- Effect of the multiple electron irradiation --- p.76 / Chapter 4.3.6 --- Optimized Conditions --- p.79 / Chapter 4.4 --- Conclusions --- p.84 / Chapter 5. --- CONCLUSIONS --- p.85 / Chapter 5.1 --- Conclusions --- p.86 / REFERENCES --- p.87 / APPENDIX --- p.91 / Appendix A Simple pulse sequence program for ESI FTICR-MS experiments --- p.91 / Appendix B Pulse sequence program for ESI FTICR-MS electron capture dissociation --- p.95 / Appendix C Pulse sequence program for ESI FTICR-MS electron capture dissociation experiments with collision cooling --- p.99 / Appendix D Modified pulse sequence program for ESI FTICR-MS electron capture dissociation experiments with a time lag between collision cooling and electron irradiation. --- p.104 / Appendix E Modified pulse sequence program for ESI FTICR-MS electron capture dissociation experiments with multiple irradiation --- p.109

Thesis (M.S.)--Oregon Graduate Center, 1977.

Thesis (Ph. D.)--Ohio State University, 2001. / Title from first page of PDF file. Document formatted into pages; contains xiii, 165 p.; also contains graphics (some col.). Includes abstract and vita. Advisor: Jonathan P. Pelz, Dept. of Physics. Includes bibliographical references (p. 160-165).

Thesis--M. Phil., University of Hong Kong, 1983.

published_or_final_version / Physics / Master / Master of Philosophy

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