A procedure has been developed for the preliminary selection of high-performance systems for office buildings in hot and humid climates. High-performance building systems and components were surveyed for buildings in the U.S., which were applicable for office buildings in hot and humid climates. This research developed a calibrated DOE-2.1e simulation model of a prototypical large office building. In addition, a Simplified Geometry DOE-2.1e (SGDOE-2.1e) model, was also developed, which used a simplified geometry to demonstrate the use of a proposed easy-to-use tool. The calibrated DOE-2.1e simulation model and the SGDOE-2.1e were compared and showed a good match with each. The SGDOE-2.1e model was then further modified based on the ASHRAE Standard 90.1-1999 commercial building energy code. A code-compliant (ASHRAE Standard 90.1-1999) SGDOE-2.1e simulation model was then used as a baseline for the evaluation of the high-performance measures. A total of 14 high-performance measures were implemented including the energy savings, while the comfort level was maintained based on the ASHRAE comfort zone. In addition to the 14 high-performance measures, solar thermal and solar PV system analysis were integrated with the SGDOE-2.1e simulation model to further reduce the annual energy use. Finally, specifications of the proposed easy-to-use simulation tool were developed. This tool includes options to choose systems from the 14 high-performance measures and solar systems. The proposed easy-to-use systems selection tool can be used for new building practitioners and existing building owners as well to evaluate the performance of their new buildings compared to the ASHRAE Standard 90.1-1999 code-compliant building, and to assess the feasibility of implementing high-performance measures to their existing buildings in terms of energy and cost savings.