Hunting by horticulturalists in the Southwest examines the impact of horticulture on hunting behavior and animal exploitation among late Archaic and Hohokam Indians in south-central Arizona. A model incorporating ecological and ethnographic data discusses the impact horticulturalists had on the environment and the ways in which that impact affected other aspects of subsistence, specifically hunting behavior. The model is then evaluated using a regional faunal data base from Archaic and Hohokam sites. Five major patterns supporting the model are observed: (1) a reliance on small and medium-sized mammals as sources of animal protein, (2) the use of rodents as food, (3) the differential reliance on cottontails (Sylvilagus) and jack rabbits (Lepus) at Hohokam farmsteads versus villages, (4) the relative decrease in the exploitation of cottontails versus jack rabbits as a Hohokam site was occupied through time, and (5) the recovery contexts of artiodactyl remains, which indicate their ritual and tool use as well as for food.