Customer relationship management (CRM) systems are widely used for effective business relations management. CRM is not software, it is business strategy, experience, knowledge. It also could be successfully applied to health care sphere. Patient relationship management system could substantialy increase effectivenes of health care process. Methods for evaluation of Patient – doctor relationships were investigated in aim to reveal most suitable ones to be used for optimization of healing process. Continious functions reflecting direct proportionality to impact factors and contrar propotionality to patients profile should be used for mathematical description of patient – doctor relationship. Optimal control of the healing process could be achieved through individualization of actions to be taken in case of every single patient. MySQL 4.1.8-nt could be used as suitable database platform for health care CRM systems. It showed high performace in tests with CRM system prototype. The prototype patient – doctor relationship management system was elaborated for usage in all possible areas of health care service.