No description available.

No description available.

No description available.

No description available.

Hair cell trauma from aminoglycosides, which may lead to permanent loss of hair cells in mammals, was studied physiologically in frogs by measuring an auditory evoked potential (AEP) in Rana pipiens. The AEP was evaluated in order to measure threshold shift (TS) and recovery from TS after the administration of the aminoglycoside antibiotic, gentamicin. To obtain an AEP, chronic electrodes were implanted into the cranium near the cochlear nucleus. The frogs were then exposed to frequency-specific narrow band ~clicks" which included a single period 1 kHz sinewave, and a computer synthesized high frequency and low frequency click. Amphibians have two hearing organs, the amphibian and basilar papillae, sensitive to low (150-1500) and high (1500-2000) frequencies, respectively. The low (AP) and high (BP) frequency clicks were created to stimulate specifically the corresponding papillae. After normal thresholds were recorded for each frog, gentamicin sulfate, 200 μM, 300 μM, or 400 μM, was injected bilaterally into the otic capsules. Thresholds were recorded until the TS had disappeared, allowing the threshold recovery period to be measured. The injections of 200 μM yielded a 10 dB change in one animal and no change in two others. The injection of 300 μM into 10 frogs and 400 μM into 20 frogs yielded at least a 10 dB change in 60% and 93% of the frogs, respectively, with the concentration of 400 μM producing threshold shifts of 20 dB. Thus, the threshold shifts were dose-dependent. Recovery times varied between six and fourteen days. No apparent differences between thresholds for the high frequency click, low frequency click and sinewave clicks were observed.

published_or_final_version / abstract / toc / Pharmacology / Master / Master of Philosophy

Bibliography: leaves 148-189. / viii, 189 leaves, [5] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / A transgenic rat model was developed to allow the study of the effects of GH expression, growth regulation and reproductive function. Transgenic rats were created by pronuclear microinjection of a human metallothionein promoter porcine growth hormone (pGH) gene construct. / Thesis (Ph.D.)--University of Adelaide, Dept. of Obstetrics and Gynaecology, 1996?

Addenda inserted inside back fly-leaf. / Bibliography: leaves 185-229. / xxiv, 229, [42] leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Using a rat model of CRF (chronic renal failure), examines the effects of treatment with recombinant human (rh)IGF-I, rhGH and rhIGH-I + GH. Tests the hypothesis that uraemic resistance to both GH and IGF-I is evident in derangements in the GH/IGF-I axis contribution to growth retardation in children with CRF. / Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 1996?

No description available.

Depot medroxyprogesterone acetate (DMPA) is a long acting progesterone only contraceptive agent. Side effects such as irregular bleeding patterns and weight gain are attributed to discontinuation. The purpose of this study was to describe depot medroxyprogesterone acetate discontinuation after weight gain in 17 to 19 year-old adolescent girls.