Class of 2017 Abstract / Objectives: To determine the cost-effectiveness of proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors with high-intensity statins compared to high-intensity statins alone for the treatment of heterozygous familial hypercholesterolemia (HeFH). Methods: A Markov model was built through TreeAge Pro to model two groups: patients taking PCSK9 inhibitors with high-intensity statins or high-intensity statins alone. For each group, there were five health states that patients could be in: well, unstable angina, myocardial infarction, ischemic stroke, or death. The data used in the model were extracted from published clinical trials evaluating PCSK9 inhibitors and statins. Results: For the primary analysis, the overall cost and effectiveness was $31,390.93 and 23.01 for the statin alone group and $362,798.50 and 24.32 for the PCSK9 with statin group, respectively. The incremental cost, incremental QALY, and incremental cost-effectiveness ratio (ICER) was $331,407.60, 1.31 QALYs, and $252,833.60/QALY, respectively. Conclusions: Since the calculated ICER was higher than the pre-established threshold of $150,000, the results from our primary analysis suggest that treatment of patients with HeFH with a PCSK9 inhibitor and a high-intensity statin is not cost effective, compared to treatment with a high-intensity statin alone. However, when certain parameters (cost of PSCK9 and mortality rate) were adjusted in the secondary analyses, these agents appear to be cost-effective.

Environmental concern and the possibility of energy shortages have drawn attention to means for recovering material and energy resources from waste products. The focus of this thesis is on the application of cost-benefit analysis as a methodological technique for evaluating the economics of resource recovery: namely used lubrication oil. The study initially focuses on the general concern of the economics of resource recovery. This is undertaken primarily by a review of existing literature. An investigation of cost-benefit analysis as advanced by Pearce, Pearce and Dasgupta, Canadian Treasury Board Secretariat, Winch, Nath, Anderson, and Settle, to name a few, reveal a comprehensive and systematic framework for the evaluation of public investment alternatives. Items for inclusion in the analysis are all costs and benefits to every member of, a defined society whose welfare would be affected by the project if implemented. Many goods and services do not enter into the market system, causing difficulty in deriving monetary values for some of the components, especially environmental concerns. For example, the case study reveals two areas: 1) benefit of pollution abatement stemming from resource recovery of used lubrication oil, and 2) costs associated with the improper disposal of the waste products from the recycling process of used lubrication oil. An attempt is made to apply the cost-benefit framework to the case of lubrication oil recycling in the province of British Columbia. Adequate quantitative data were not available, particularly on the social costs and benefits, to fully employ the cost-benefit technique, therefore restricting the analysis in that only an identification of costs and benefits was prepared. When quantification of costs and benefits is not possible, a detailed description of the unquantifiable items indicates to the decision maker the extent of the components. Included in this study is a presentation of the environmental impacts of used oil disposal. The limitations of the cost-benefit analysis as an evaluation technique arise because of limited information and data needed to evaluate, in monetary terms, environmental improvement. Future research could involve a "simulation" of the market to determine a plausible shadow price that gives an indication of what the market price of the item would have been if it had been normally traded. A determination of the price that consumers would be willing to pay for the benefits of pollution control with the knowledge that some pollution would be produced by the recycling activity would aid the analyst in placing values on the costs and benefits. / Applied Science, Faculty of / Community and Regional Planning (SCARP), School of / Graduate

The relationship between organizational culture and organizational effectiveness has been the subject of much research by Daniel Denison. Much of this research has been conducted in developed countries where the environment is highly competitive, highly productive and the economies are stable. There has been the challenge however to determine if the findings of such research are relatively universally consistent. In this case the challenge is to determine if the findings hold in circumstances where the economies are less developed and more fragile than those previously studied. This research study is designed to examine the relationship between organizational culture and organizational effectiveness in circumstances typical of the English speaking Caribbean where the economies are weak and in some respects informal and to use these findings to compare with earlier findings from developed economies. The research study involves the administration of the Denison Organizational Culture Survey which was also used in the earlier studies, to persons engaged in the electronic media sector in the English-speaking Caribbean. This sector has the characteristic of competitiveness which is typical of other industries studied. The evidence points to a strong correlation between organizational effectiveness and all four of the Denison culture traits. The adaptability and the mission traits were identified as the more dominant and the organizations reflected an external focus. The results of the study indicate that notwithstanding the economic foundational differences, the findings hold true of a positive relationship between organizational culture and organizational effectiveness similar in extent to and in some cases stronger than earlier studies and as such provided support for the previous research findings.

This study aimed to secure and evaluate the current practices in teaching of geography within the rural school system of Colon County, Texas. The objectives of the study were also to learn from the County rural supervisors of the state the procedures they are using together with their recommendations for the present needs in geography teaching.

No description available.

No description available.

In recent years, the concept of poverty has shifted away from a narrow definition—caloric intake based poverty—to a much broader one that places emphasis on a variety of factors, such as health, education, income, and powerlessness. Most researchers agree that eliminating poverty requires a holistic approach that is attentive to promoting pro-poor growth, creating opportunities for employment, ensuring that the fruits of growth reach impoverished communities, and protecting vulnerable segments of the impoverished population. This study looks the role of microcredits, which has received increasing attention as a means to combat poverty. The advent of neoliberalism led to advances in autonomous markets, commodification, market-led growth, and the dissolution of the Keynesian welfare state. Microcredit growing out of a neoliberal shift plays a powerful role as an instrument to fight poverty, especially in the age government and state failure, entrepreneurial expansion and self-employment income-earing opportunities. Microcredit programs are of great interest to governments, non-governmental organization, and banks because of their potential for reducing poverty. Critics of the microcredit movement argue that microcredit does little besides replacing existing informal credit arrangements to fund subsistence activity, which they view as having little or no prospect of growth. They argue that support of microcredit may over anticipate its benefits, such as the alleviation of poverty and female empowerment. This study assesses the effectiveness of microcredit combined asset building as a pro-growth approach to reduce poverty sustainably in Kinshasa. The recent crises of over-indebtedness in several markets and Kinshasa have fueled growing concern that microcredit may be getting borrowers into trouble. However, my study findings show that assets, specifically microcredit, can stem the poverty cycle and better enable individuals to "stand on their own two feet"socio-economically if combined with other innovative programs. This study uses the test of significance to assess the effectiveness microcredit integrated asset building. / Ph. D.

This case study considers the relative costs of conflict prevention and post-crisis intervention for Sudan during the period 2004-2018.

A survey of cost effectiveness methodologies used in the defense industry is presented and an application of cost effectiveness is developed. A breakdown in the level of the decisionmaking is made and follows the example of the Weapon System Effectiveness Industry Advisory Committee. Examples of cost effectiveness methodologies at each decisionmaking level are shown.

Current research suggests that by actively involving students, you can increase pedagogical value of algorithm visualizations. We believe that a pedagogically successful visualization, besides actively engaging participants, also requires certain other key features. We compared several existing algorithm visualizations for the purpose of identifying features that we believe increase the pedagogical value of an algorithm visualization. To identify the most important features from this list, we conducted two experiments using a variety of the heapsort algorithm visualizations. The results of these experiments indicate that the single most important feature is the ability to control the pace of the visualization. Providing a good data set that covers all the special cases is important to help students comprehend an unfamiliar algorithm. An algorithm visualization having minimum features that focuses on the logical steps of an algorithm is sufficient for procedural understanding of the algorithm. To have better conceptual understanding, additional features (like an activity guide that makes students cover the algorithm in detail and analyze what they are doing, and pseudocode display of an algorithm) may prove to be helpful, but that is a much harder effect to detect. / Master of Science